Jack Goodall

So this interview lasted 2 hours so this “you’re scaring me” part might seem like an overreaction or fearmongering to someone without that context.

There’s a lot of evidence to support my hypothesis that a potential H5N1 pandemic would be worse than COVID.

a woman says " i feel the conflict in you " ALT: a woman says " i feel the conflict in you "

ID gurus - what are your thoughts on the optimal tx for S. pneumo meningitis that is pansensitive?

ESCMID guidelines: PCN or amp/amox
IDSA guidelines: PCN
NICE guidelines: Ceftriaxone

PCN: lower risk of CDiff, antimicrobial stewardship rizz
Ceftriaxone: fewer infusions, pt already on this

#IDsky

The danger of course is that this nuance is lost on whoever orders the test and TB gets erroneously “ruled out”. This seems to be more of an issue of education and result presentation that an intrinsic fault in the test

I’ve often wondered about whether we are too dogmatic about this in ID. There are lots of tests (eg all of the physical exam!) that have comparably bad performance characteristics. We don’t pretend they are 100 sens/spec but understand their limitations and do a good bit of Bayesian inference

Great summary Alasdair. I suspect asymptotic carriage is less of a phenomenon in adults - but still happens.
Some of my colleagues would argue though that the specificity is near enough 100% in adults that the diagnosis is made when you get a +ve (NPS) PCR. Anyone got thoughts (or a reference!)?

Our @shorten2trial.bsky.social aims to confirm that 7-day treatments are superior to 14-day courses for uncomplicated P. aeruginosa BSI.
Check out our full protocol 👉🏻 journals.plos.org/plosone/arti...
#AMSsky #IDSky

Greater preservation of SARS‐CoV‐2 neutralising antibody responses following the ChAdOx1‐S (AZD1222) vaccine compared with mRNA vaccines in haematopoietic cell transplant recipients Knowledge of factors impacting immune responses after COVID-19 vaccination is essential for guiding revaccination strategies in haematopoietic stem cell transplant (HSCT) and chimeric antigen recepto...

💉 How do we optimise the neutralising antibody responses of HSCT/CAR-T recipients following COVID vaccination? We found ChAdOx1-S recipients were EIGHT times more likely to have neutralising antibodies than those receiving mRNA vaccines in our new paper! Read more --> doi.org/10.1111/bjh....

Ah amazing - glad you liked it! Please do feel free to add to it

BIA now on blue sky 👏 - and please consider applying for our ECR and small project grants!

A global health starter back would be a great public service. I’m an ID clinical academic currently working on bacterial/viral confection in West Africa

This is a really useful insight that hopefully will guide how we prevent future spill overs

Looks like the link Bluesky has made doesn’t work - but clicking the link directly in the text is fine

It's fine on a phone but best read on a browser.

This project started life as a custom markdown template for our research group. The tutorial links to that package and has a section at the bottom on customising the logo and branding for your lab/group.

R markdown is an amazing way to share pre-publication findings with colleagues and collaborators.
If you use R but haven't taken advantage of markdown then I have a tutorial just for you: jackwgoodall.github.io/floreytemplate
It's new so I would love your feedback.
#IDsky #AcademicSky #episky

IMage showing vaccine vials, resarchers etc to illustrate the call for the Eurosurveillance annual theme 2025: "Vaccine-preventable diseases in humans — today's challenges and tomorrow's opportunities"

New to this place 🦋, moving on from the other place

Here to provide you #EpiSky #IDsky updates from Europe's weekly, peer-reviewed scientific journal on infectious disease epidemiology, prevention & control

#PublicHealth

Submit your papers now for our annual theme 2025 😷💉
bit.ly/annualtheme25

🧵Next week, you will see people using something called Benford's Law to try to prove election fraud.
⛔️These people are wrong⛔️
I am a scientist who has published on Benford's Law. Let me tell you what it is and why what they are doing is mathematically incorrect. 1/

(Key **players** this should say!)

I was lucky enough to work on the AMBITION trial (although had nothing to do with the design) and it has to be said that their motivation was to improve treatment options in low resource settings. This is just a happy bonus.

But PICC lines and hospitalisation are risky anywhere (especially if you have no immune system). This feels especially relevant to people how are surprisingly well with crypto but would be very vulnerable to nosocomial complications.

The design is very smart as it has hard fungal dynamic outcomes too. If it didn’t have this then you could easily argue that the risks/benefits of hospitalisation and long term IV access could be different in different countries.

How Applicable Is the Single-Dose AMBITION Regimen for Human Immunodeficiency Virus–Associated Cryptococcal Meningitis to High-Income Settings? The AMBITION-cm trial showed that a single, high dose of liposomal amphotericin B, given with oral fluconazole and flucytosine, is an effective treatment f

There is an excellent article by the key player in the AMBITION-cm trial on just this topic: academic.oup.com/cid/article/....

Microbiome-based correction for random errors in nutrient profiles derived from self-reported dietary assessments - Nature Communications Here, the authors introduce METRIC, a deep-learning method that corrects measurement errors in self-reported dietary nutrient profiles using assessed data and microbial composition, effectively enhanc...

This is an amazing idea - using microbiome assessments to account for the inaccuracies that are invariably present in self reported diet recall www.nature.com/articles/s41...

Amazing public service. Thank you!

patrick star from spongebob squarepants is standing on a sandy beach next to a black line . ALT: patrick star from spongebob squarepants is standing on a sandy beach next to a black line .

Dear IDTwitter refugees

I made an #IDSky starter pack which makes it easy to find accounts of ID clinicians, medical microbiologists, ID researchers, ID epidemiologists, ID focused reporters, and of course journals ahead of the curve. Let me know if I missed you!

go.bsky.app/LnAQjdq

Did it. Got approval to stop posting at X. Please #IDSky #MedSky people, feel free to follow @cmicomms.bsky.social, ESCMID's #OpenAccess journal on all things #infectiousdiseases, #clinicalmicrobiology, #AMR, and host of the #Communicable podcast, so I can show that we were right! :-)

Protecting healthcare and patient pathways from infection and antimicrobial resistance Innovative whole system approaches to integrate research and novel technologies within patient pathways are needed to target antibiotic use, minimise healthcare associated infections, and adapt to nov...

"Exposure to healthcare has a large role in the transmission of infectious diseases and acquisition and transmission of antimicrobial resistance"
#IDSky #MicroSky #MedSky

www.bmj.com/content/387/...

Towards shorter, safer, flexible, and more effective treatment regimens for drug-resistant tuberculosis There has been an important shift during the past 10 years in the approach to treating drug-resistant tuberculosis.1 Around a decade ago, the treatment of multidrug-resistant or rifampicin-resistant t...

Towards shorter, safer, flexible, and more effective treatment regimens for drug-resistant tuberculosis

#TB #IDSky 🩺🧪 #AMR

www.thelancet.com/journals/lan...

@gpollara.bsky.social thank you for spotting the last link wasn’t working! Try again

Diagnostic Dilemmas: A Review of Reported Cases of Human Herpesvirus 6 Encephalitis in Immunocompetent Adults Human Herpesvirus-6 Encephalitis is exceedingly rare amongst the immunocompetent population. This review article identifies the available records of HHV-6

academic.oup.com/ofid/article...

We have recently changed CSF viral panel and now get HHV6 results for all patients. Positive results in immunocompetent patients have caused a fair amount of debate (not least because of chromosomal integration). I found this review very helpful.
#IDSky