Tom Driedonks

Early Career Researcher Travel Grants for UKEV Forum 2025 - UK Society for Extracellular Vesicles Early-career research travel grants for UKEV Forum 2025 UKEV Travel Grants are available to help early career researchers (the applicants) attend and present their research at the UKEV Forum (15th to ...

Some travel grants for UKEV if there are any big UK extracellular vesicle fans out there!
🧪

www.ukev.org.uk/early-career...

Extracellular Vesicles and B Cell Interactions: B-Side Track or Greatest Hit? Substantial efforts have been made in understanding interactions between extracellular vesicles and cells, particularly in small animal models, such as rats and mice. However, many questions remain un...

Happy to have contributed to this perspectives article about interactions between therapeutic EVs and circulating B cells.
Unexpected discovery, confirmed in different experimental settings. Curious to learn more about these interactions and their therapeutic potential
pubs.acs.org/doi/10.1021/...

Abstract submitted for #NLSEV2025!
@nlsev.bsky.social

We don't know yet, it will take a while to process all of the samples. Luckily we don't have to do all of that in one day 😄

Had a 14h shift in the lab yesterday. Mice experiment followed by magnetic sorting of different cell types from tissues. Too many washing steps but there were some cells left in the end. Next step is to see whether my EVs have reached their destination 😅

We have some exciting news to share..... #JExBio is now indexed in Web of Science!!🎉🎉🎉

Yes! Mention of #extracellularvesicles in a @kurzgesagt.org popular science video about pregnancy. Wait until they learn about all the processes EVs play a role in 🤓

mGem: Guides or triggers? Extracellular RNAs beyond vesicular miRNAs | mBio Blood and other extracellular biofluids have a high RNase content. Hence, from its origins, the exRNA field has focused on extracellular vesicles (EVs) as the main carriers of RNA molecules that move ...

With @amyhbuck we wrote this piece on extracellular RNAs that intends not to give answers but to propose questions that can expand the field in new directions.

Hope you like it! We really enjoyed a lot brainstorming it.

journals.asm.org/doi/10.1128/...

😎 You can already submit your abstracts for #ISEV2026, in Puerto Rico!
🌴 Submit before 13th January 2026, there will be NO late breaking submission
www.abstractscorecard.com/cfp/submit/l...

YouTube video by EVClub: Extracellular Vesicle Club Education Day 2025 Part 1: EVs. What are they? Where are they from? Where do they go?

🎼 Did you know all #ISEV2025 Education Day Talks are on our YouTube channel?
🤩 Check out our playlist: youtu.be/ovtLcTMeyQU?...

do you ever stare at the ceiling and think about how the worldwide scientific establishment did the impossible and created a COVID vaccine in under a year and the response of the general public has been to go on an unstoppable rampage to destroy science and scientists

📢Call for papers!📢 #JExBio is pleased to announce its first Special Issue 'The Biomolecular Corona of Extracellular Vesicles'. Guest Edited by Professors Massimo Bottini, Benedetta Bussolati, and Annalisa Radeghieri. isevjournals.onlinelibrary.wiley.com/hub/journal/...

ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.

If you haven’t already, please consider signing & sharing this! NIH public servants defending the integrity of our publicly funded health research need our voices. This administration is
“damaging the hard-earned trust between the NIH, academia, & the public that is essential for long-term progress”

Very cool findings but kit-based 'exosome' isolation kits, like used in this paper, isolate many other things in culture medium. It would be good to validate this on a proper (density gradient or size-exclusion) EV isolate

🚨 EV Fundamental Biology Series: The 'dark matter' RNA of Extracellular Vesicles

This June 12th, join us for a relevant talk on the vesicular RNA topic!

Extracellular exosomal RNAs are glyco-modified - Nature Cell Biology Sharma, Jiao and colleagues report glycosylation of small RNAs within exosomes and propose a glycosylation-dependent mechanism for RNA targeting into exosomes, which may influence intercellular commun...

More insights into #glycoRNA, this time found within exosomes!

www.nature.com/articles/s41...

I'll do that! I noticed your thesis cover on the wall of the department, with the pelican and the ice cube. It's a small world after all!

Modulating binding affinity of aptamer-based loading constructs enhances extracellular vesicle-mediated CRISPR/Cas9 delivery - PubMed The CRISPR/Cas9 toolbox consists of modular nucleases that can be employed to efficiently modify genomic sequences with high specificity. However, delivery of the large Cas9-sgRNA ribonucleoprotein (R...

Happy to have contributed to this paper by @olivier-de-jong.bsky.social!
A proper balance of loading versus unloading of Cas9 RNPs is needed for effective gene editing ⚖️
pubmed.ncbi.nlm.nih.gov/40393529/
Congratulations to all co-authors!

📢 Come be a part of the SNEV team!

We’ve got 3 exciting positions open:
1️⃣ Media Team (1 position)
2️⃣ Podcast Team (2 positions)

🗓️ Deadline to apply: May 31st
⏳ Don’t miss your chance to make an impact. Apply NOW!
📩 Link in the Linktr.ee in our bio

I deep fried two of my SDS PAGE gels today but my most important samples were on gel nr 3 so things are going quite well today 🫠

Personalized gene editing! What a time to be alive

Inhibition of acid or neutral sphingomyelinases differentially impacts RNA and protein cargo sorting to extracellular vesicles Extracellular vesicles (EVs) form through regulated biogenesis processes involving sphingomyelinases (SMases), enzymes that metabolize sphingomyelin t…

Pretty cool study showing the effect of acid sphingomyelinase on non-coding RNA cargo of MCF-7 EVs.
Big changes in 'miscRNAs' 7SL and Y3 RNA, and functional effects in wound healing
www.sciencedirect.com/science/arti...

Great that Europe provides opportunities for US researchers. Could strengthen Europe's position as scientific stronghold.
I hope this does not go against opportunities of European researchers. Grant money is competitive enough already, and anti science policies are on the rise here, too 😕

NLSEV is well-represented at #ISEV2025 !

@esthernoltethoen.bsky.social @lorenowiczaims.bsky.social @cscheepbouwer.bsky.social @olivier-de-jong.bsky.social

How a scientist–pop industry partnership slashed a live gig’s carbon emissions by 98% Climate researchers collaborated with the trip-hop band Massive Attack to reduce the climate impact of live music.

Climate researchers collaborated with the trip-hop band Massive Attack to reduce the climate impact of live music

https://go.nature.com/4hXzB0Y

From 4L to 15mL, getting somewhere!
#extracellularvesicles

Big EV production this week!
Thanks Bart Boogaard, new PhD student in our team and technician Annet van Wesel for great help 💪
Labwork is better together 🧫
(that's just 1 our of 2 full incubators 😎)

❓ Have you registered already for #ISEV2025?
🐤 Don't wait, early bird discount rates last until March 7th!
buff.ly/3CyMjEE

The 2025 edition of the #EMBOEVs EMBO practical course on #extracellularvesicles has started! Our highly distinguished keynote speaker Edit Buzas @editbuzas.bsky.social enlightens the participants on the large diversity of EVs.

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.

This is pretty wild?

www.nature.com/articles/s41...