Lucy Bell

Excited to get my brain back into gear and will be at poster 444 on Wednesday talking about HIV, TLR8 and macrophage epigenetic remodelling.

Back from mat leave and straight into the thick of it at BSI Congress 2025 #bsi25. V grateful to @britsocimm.bsky.social awarding me a carer’s grant so I was able to come with baby & family in tow to look after him! Easing the transition for both of us and wouldn’t have been able to come otherwise.

Post-tuberculosis lung disease: a case definition for use in research studies Despite growing awareness of the substantial burden of long-term pulmonary impairment among tuberculosis survivors, marked variability in how post-tuberculosis lung disease is defined across research ...

Post-TB lung disease - the impact of TB on patients does not end with the course of antibiotics, characterised by substantial long-term pulmonary impairment.

Proposed case definition to support assessments and interventions in research studies 👇

#TBSky #IDSky @thelancetinfdis.bsky.social

Great study in @jexpmed.bsky.social.
IFNAR1 or IFNAR2 complete deficiency leads to severe viral disease. Here, authors identify 11 mutations where heterozygosity predisposes to severe viral disease by negative dominance. 1 is common. Paper: rupress.org/jem/article/...

The dynamics of interferon-stimulated gene expression in COVID-19 depends on their underlying epigenetics in specific cell types, with impacts on their utility as blood RNA biomarkers. Great to contribute to this study bringing insights into diagnostics from immune cell epigenetics
#IDSky #ImmunoSky

SARS-CoV-2 human challenge reveals biomarkers that discriminate early and late phases of respiratory viral infections - Nature Communications It’s not always clear whether blood biomarkers are differentially expressed in the time course of viral infections. In this SARS-CoV-2 human challenge study, the authors identify distinct single-gene ...

Also out now.. after peer review, our analysis of blood transcriptional biomarkers of acute respiratory viral infection leveraging the SARS-CoV-2 human challenge model: www.nature.com/articles/s41...

Working on type I interferons in TB and would love to be added 😊

This is a great thread on #UnionConf2024, and useful for anyone who like me was not able to attend.

Thank you for putting together. #TBSky #IDSky

Results 10 yrs metagenomic sequencing for CNS infections www.nature.com/articles/s41...

Impressive.

Key take homes for me.
1) Time to result still long - addressable but a barrier currently.
2) 10% contamination.
3) Despite using cutting edge tests a "causative" organism found in only 15%.

Looks like a fabulous resource! #IDsky