MPI for Biology Tübingen & Friedrich Miescher Laboratory's Avatar

MPI for Biology Tübingen & Friedrich Miescher Laboratory

@mpi-bio-fml.bsky.social

A joint channel for the Max Planck Institute for Biology Tübingen & Friedrich Miescher Laboratory. We study aspects of microbial, algal, fungi, plant & animal biology. www.bio.mpg.de/ www.fml.tuebingen.mpg.de/ Imprint: https://www.bio.mpg.de/3047/imprint

1,451 Followers  |  237 Following  |  528 Posts  |  Joined: 21.11.2024  |  1.9336

Latest posts by mpi-bio-fml.bsky.social on Bluesky

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The mind of a predatory worm
A new perspective piece in Science highlights a study (published in same issue) showing that a behavioural switch in nematodes (from non-predatory to predatory) is due to widespread neural changes, not just one key connection.
Link: www.science.org/doi/10.1126/...

04.08.2025 12:37 — 👍 4    🔁 1    💬 0    📌 0
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Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals - Genome Biology Background Because transposable elements (TEs) can cause heritable genetic changes, past work on TE mobility in Arabidopsis thaliana has mostly focused on new TE insertions in the germline of hypometh...

Paper led by @movillome.bsky.social on unbiased detection of (somatic) #TE insertions in #Arabidopsis with @pacbio.bsky.social long reads out after peer review. Thanks to academic editor Leandro Quadrana for shepherding it through the review process.
#plantscience
link.springer.com/article/10.1...?

31.07.2025 07:43 — 👍 50    🔁 29    💬 1    📌 2
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New Research! Our postdoc Kateryna Maksymenko & co. developed a new method making it possible to design custom proteins that bind precisely to specific sites in diseased cells. A big step for the development of targeted drugs, esp. cancer.

Find out more: www.bio.mpg.de/476284/news_...

29.07.2025 12:29 — 👍 2    🔁 0    💬 0    📌 0

Two of our researchers, Gesa Freiman and Alexandra Waldherr, are giving short, interactive and engaging talks as part of #SoapboxScience Tübingen this Saturday!
📌Holzmarkt, Tübingen (Georgsbrunnen)
🕐 13:00 to 16:00
soapboxsciencetuebingen.github.io

23.07.2025 10:00 — 👍 2    🔁 2    💬 0    📌 0
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Hassan Salem Interview with Hassan Salem, who studies beetles and their microbial partners at the Max Planck Institute for Biology.

Grateful to the folks @CurrentBiology.bsky.social for the fun Q&A!

Come for the beetles, stay for the symbionts — and forgive the basketball detour 🪲🦠🏀

www.cell.com/current-biol...

17.07.2025 08:45 — 👍 46    🔁 17    💬 1    📌 0
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Join us again this Friday for the next Distinguished Speaker Seminar Series talk to be delivered by Prof. Dr. Pulin Li from MIT. Everyone is welcome!

▶️More info: shorturl.at/Xk3li
📆: Friday 25th July at the earlier time of 11am
📍: MPI-BIO seminar room (ground floor)
#DSSS

21.07.2025 06:17 — 👍 1    🔁 0    💬 0    📌 0
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📌 #OffeneStelle #WirSuchen #Jobs
Bitte teilen

Die Stelle als Pressesprecher/ Pressesprecherin ist noch offen. Muttersprachler sind super willkommen!

▶️ befristeter Vertrag für 2 Jahre
▶️ Bewerbungsfrist: 28 Juli 2025

lnkd.in/drNzYgvQ

10.07.2025 13:07 — 👍 1    🔁 1    💬 0    📌 0

Ever needed to analyze flagellomes? @anya-bogdanova.bsky.social and @atyakht.bsky.social developed FlaPro to sort flagellins into how they are predicted to interact with TLR5: silent or stimulatory. The ratio changes with IBD! 🧫🦠

07.07.2025 16:21 — 👍 14    🔁 5    💬 0    📌 0
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🎉Congratulations to @caroleduchene.bsky.social, recipient of the 2025 "Grandes Avancées françaises en biologie" from @academiesciences.bsky.social for her research on how microalgae navigate ocean depths. Learn more: s.gwdg.de/FxdLh8
#Microalgae #ScienceAwards
Photos © Académie des sciences

08.07.2025 08:35 — 👍 17    🔁 4    💬 0    📌 0
Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD Flagellin is the protein monomer of the bacterial flagellum, which confers motility, allowing bacteria to reach their favored niches. Flagellin is highly conserved across bacterial species and thus the target of the innate immune receptor Toll-like receptor 5 (TLR5). In the gut, bacterial flagellin agonizes human TLR5, triggering a pro-inflammatory response. However, the ability to bind and activate TLR5 varies considerably between different flagellins, suggesting that the composition of an individual's flagellin repertoire - the flagellome - may mediate the inflammatory response to the microbiome, with relevance to inflammatory bowel diseases. However, to date, methods to assess the inflammatory potential of a flagellome are lacking. To address this gap, we constructed a curated database of human gut flagellins. To predict the inflammatory potential of the flagellome by sorting flagellins into either "stimulatory" (strong TLR5 agonists) or "silent" (weak TLR5 agonists), we trained a machine learning model on experimentally characterized flagellins with known binding and stimulatory activities. The FlaPro pipeline was implemented using the Snakemake workflow engine for high-throughput analysis and is available at https://github.com/leylabmpi/FlaPro. To validate our approach and explore clinical associations, we applied FlaPro to a publicly available multi-omics dataset from an inflammatory bowel disease (IBD) cohort. Our analysis demonstrates that FlaPro enables robust profiling of the human gut flagellome from metagenomic and metatranscriptomic data. Analysis of the IBD datasets revealed a depletion of flagellome diversity and a reduced silent-to-stimulatory flagellin abundance ratio in Crohn's disease and ulcerative colitis, observed at both the genomic and transcriptional levels. Multiple condition-specific alterations were identified at the level of individual flagellin clusters. These findings indicate that IBD is associated with distinct alterations in the gut flagellome, particularly in relation to TLR5 recognition. Flagellome features represent a functionally interpretable class of microbiome-derived markers with potential utility in microbiome-wide association studies in the context of human health and disease. ### Competing Interest Statement The authors have declared no competing interest. Max Planck Society and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme Grant agreement

FlaPro - a pipeline for quantifying silent and stimulatory flagellins in the human gut - reveals how the flagellome shifts in inflammatory bowel diseases.
Congrats to @anya-bogdanova.bsky.social on her first preprint from the Ley Lab @microbiome.bsky.social !
www.biorxiv.org/content/10.1...

07.07.2025 06:48 — 👍 11    🔁 3    💬 0    📌 1

Excited to share our latest review on histone-mediated chromatin organization in prokaryotes and viruses! 🧬 @mpi-bio-fml.bsky.social

30.06.2025 09:33 — 👍 13    🔁 4    💬 0    📌 0
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Join us again this Friday for the next Distinguished Speaker Seminar Series talk to be delivered by Assis. Prof. Michael O'Donnell from Yale University. Everyone is welcome!

▶️More info: shorturl.at/o6IVn
📆: Friday 11th July at 3pm
📍: MPI-IS seminar room (ground floor)
#DSSS

07.07.2025 08:14 — 👍 1    🔁 0    💬 0    📌 0
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Come along to this Friday's Distinguished Speaker Seminar Series talk, this week to be delivered by Prof. Dr. Andreas Plückthun from the University of Zurich

▶️More info: shorturl.at/Cy1y4
📆: Friday 4th July at 3pm
📍: MPI-IS seminar room (ground floor)
#DSSS

30.06.2025 07:31 — 👍 2    🔁 0    💬 0    📌 0
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📢 Offene Stelle

Wir suchen ein*e: ▶️ IT-Spezialist*in für den IT Support

🔎 Mehr Infos unter: jobs.tue.mpg.de/en/programs/...

Wir freuen uns auf eure #Bewerbungen !

18.06.2025 12:34 — 👍 0    🔁 1    💬 0    📌 0

Congratulations Detlef! An extremly well deserved award @plantevolution.bsky.social @mpi-bio-fml.bsky.social

17.06.2025 19:45 — 👍 23    🔁 6    💬 0    📌 1
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Microbial life is the foundation of all living systems. A new
@asm.org report, with our Director Susana Coelho part of the steering committee, explores 3 key steps in Earth’s history—from simple cells to complex life— and what it means for future science.
Read more: s.gwdg.de/Dzn885

16.06.2025 07:56 — 👍 6    🔁 2    💬 0    📌 0
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Full house at our friday seminar today @mpi-bio-fml.bsky.social featuring Edwige Moyroud from @slcuplants.bsky.social on the evolution and development of pattern formation in flowers.

13.06.2025 13:09 — 👍 15    🔁 2    💬 0    📌 0
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Temperature is so important for plants that they have come up with many independent temperature sensors.

Curious? Read more in this review by former WeigelWorld members Sridevi Sureshkumar & Suresh Balasubramanian.
#plantscience
www.science.org/doi/10.1126/...

13.06.2025 05:40 — 👍 71    🔁 39    💬 1    📌 1
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Come along to this Friday's Distinguished Speaker Seminar Series talk, this week to be delivered by Dr. Edwige Moyroud from the Sainsbury Laboratory at the University of Cambridge

▶️More info: shorturl.at/2jxhp
📆: Friday 13th June at 3pm
📍: MPI-IS seminar room (ground floor)
#DSSS

10.06.2025 08:22 — 👍 0    🔁 0    💬 0    📌 0
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The inaugural @africanplantgen.bsky.social‬ symposium wasn’t just an event; it started a movement! With the launch of the African Plant Genomics Network & plans for a 2027 symposium, a stronger future for plant science in Africa is truly underway. For more info: shorturl.at/8mYf6 #PlantGenomics

05.06.2025 09:49 — 👍 8    🔁 3    💬 0    📌 0
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Come along to tomorrow's Distinguished Speaker Seminar Series talk, this week to be delivered by Prof. David Mangelsdorf from the UT Southwestern, Dallas

▶️More info: shorturl.at/3XhQC
📆: Friday 6th June at 3pm
📍: MPI-IS seminar room (ground floor)
#DSSS

05.06.2025 09:48 — 👍 1    🔁 0    💬 0    📌 0
Hebel-Gymnasium Schwetzingen | Bericht vom Landschulheim der Klasse 6e im April 2025

UPDATE: The students wrote a very sweet blog post summarising their experience in Tübingen, including a short description of their visit to the Institute:

www.hebelgymnasium.de/news/bericht...

04.06.2025 07:56 — 👍 2    🔁 0    💬 0    📌 0
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This is what a multi-floor meeting looks like at the @mpi-bio-fml.bsky.social. Love a good science lobby 😁

27.05.2025 08:18 — 👍 13    🔁 1    💬 0    📌 0
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Fantastic Proteins, Fantastic Team, Fantastic Diversity Day! 🪄

At this year's diversity day at @mpi-bio-fml.bsky.social , we shared our fascination with proteins with our colleagues.🧪

Huge thanks to my winning team: @hadeerelhabashy.bsky.social , Alex Waldherr, and Claudio Piselli ❤️

02.06.2025 11:58 — 👍 4    🔁 2    💬 0    📌 0
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On this UN’s International #BiodiversityDay, we look fwd to celebrating the Institute’s Diversity Day (27 May). The 2025 talks include “DNA, Drama & (cell) Division,” “Plants & Pathogen Prediction,” “Algae Genomes & Diversity,” & “Plasticity & Communities.” Here’s a look back at 2024 events.

22.05.2025 07:35 — 👍 7    🔁 2    💬 0    📌 0

To all my #Drosophila Pop-Gen, Quan-Gen, & Evolution pals - Submit an abstract to the European Drosophila meeting, and let's meet and discuss in the Pop-Gen and Evolution session in Alicante 🐝 (a bee 'cause there's no fly emoji 😢)

19.05.2025 15:01 — 👍 0    🔁 2    💬 0    📌 0
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‪Come along to this Friday's Distinguished Speaker Seminar Series talk, this week to be delivered by Prof. Kevin Foster from the University of Oxford

▶️More info: shorturl.at/C9YIS
📆: Friday 23rd May at 3pm
📍: MPI-IS seminar room (ground floor)
#DSSS

19.05.2025 12:13 — 👍 2    🔁 1    💬 0    📌 0
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Thrilled to share that our Director, Yen-Ping Hsueh, has received the prestigious NSTC Outstanding Research Award 🎉

▶️ Find out what this means to Dr. Hsueh: tinyurl.com/3fhsd63p

▶️ Dr. Hsueh's Dept. of Complex Biological Interactions: www.bio.mpg.de/391832/compl...

#NSTC #AcademicAward #Taiwan

19.05.2025 09:55 — 👍 3    🔁 1    💬 0    📌 0
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📢 #WirSuchen #Jobs

Wir suchen zum nächstmöglichen Zeitpunkt eine/einen Pressesprecher/ Pressesprecherin (m/w/d):

▶️ befristeter Vertrag für 2 Jahre

▶️ Bewerbungsschluss: 10. Juni 2025

Mehr Infos zur Stelle:

👉 www.mpg.de/24729027/mit...

19.05.2025 09:04 — 👍 0    🔁 0    💬 0    📌 0

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