Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes Cryptosporidium to clofazimine resistance The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti-Cryptosporidium activity of clofazimine, o...

Our latest story on Clofazimine resistance in Cryptosporidium! What started as a side project turned into one of the most interesting stories.

Genetics 101 😊

#Cryptosporidium #Apicomplexa #Clofazimine #AntimicrobialResistance #AMR #ParasiteResearch

www.biorxiv.org/content/10.1...

After this weekend’s extensive firings at NIH and CDC - focused mainly on young scientists - like the ENTIRE class of epidemic intelligence service - I have a hard time to choose my music. This is the closest I have been to bitter - in my 30 years in US science.

Global Parasitology Seminar next Monday: Ira Blader on Toxoplasma & oxygen. 2/10/25 12 pm EST in person & zoom. ⁦‪@TrendsParasitol‬⁩ ⁦‪@BSPparasitology‬⁩ ⁦‪@parasitesrule‬⁩ ⁦‪@AmSocParasit‬⁩ ⁦‪@AS_Para‬⁩ ⁦‪@pennvet‬⁩ ⁦‪@SFParasitologie‬⁩ ⁦‪@CTEGD‬⁩

As the days begin to wear on me and I wake up with more worry than usual I saw this (posted by ‘English Literature’) … and it saved some part, of a day I rued.

First Global Parasitology Seminar of 2025: Nathan Schmidt on Malaria & Microbiome. Monday 01/27 12 pm US EST. @womeninmalaria @BSPparasitology @FightingMalaria @AmSocParasit @UPenn_I3H @MBLBoP

Are you interested in #trypanosomes #biomolecularcondensates and/or #geneexpression? We are looking for a highly motivated postdoc to work with with us in the beautiful city of York!

Please share!

jobs.york.ac.uk/vacancy/post...

Come and celebrate the exceptional career of Mark Carrington (24th March at University of Cambridge)!

The American Association of Immunologists - Current Recipients This program annually recognizes members for distinguished careers and outstanding scientific contributions as well as their service to AAI and the immunology community. Click here for more…

Go and see a new picture of the handsome Dr. Hunter who was elected a Distinguished Fellow of the The American Association of Immunologists for 2025! Congrats! https://www.aai.org/Awards/Career-Awards/Distinguished-Fellows-of-AAI/Current-Recipients?utm_source=community_alert&utm_medium=email_header…

The Toxoplasma rhoptry protein ROP55 is a major virulence factor that prevents lytic host cell death Nature Communications - Ruivo et al uncover a Toxoplasma survival mechanism conserved across different cell types and species. By repressing NF-kB activation and lytic host cell death pathways, the...

Delighted to share our study on a major Toxoplasma virulence factor that prevents lytic host cell death.
Many thanks to @parafrap.bsky.social for support, constructive reviews and all labs involved: Melissa Lodoen, Hiba El Hajj, @gissotlab.bsky.social, Karine Le Roch
Link : rdcu.be/d6m3G

First meeting of 2025 this Wednesday!

Don’t miss Yi-Wei summarizing his amazing work as an Assistant Professor. This will be both, great science and a lot of fun!

Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes - Nature Communications This study reveals that the genomes of animal-adapted Cryptosporidium hominis subtypes differ from common human subtypes in the copy number of subtelomeric MEDLE genes, contributing to their…

Terrific new paper on C. hominis pathogenesis: Multicopy subtelomeric genes underlie animal infectivity of divergent Cryptosporidium hominis subtypes | Nature Communications https://buff.ly/4fPE4li

My neighborhood has a cool new mural!

Belated holiday wishes everyone! I don’t have a Christmas sweater in me but Bethan Wallbank suggested this as closer to my persona. BTW if you (like me) are still figuring out whether to ditch X for bluesky, try the app called buffer where you can do both with one post for now.