Nate Sherer

Nate Sherer

@natesherer.bsky.social

University of Wisconsin-Madison McArdle Laboratory for Cancer Research and Institute for Molecular Virology. Viruses and cells. Opinions my own.

1,545 Followers 448 Following 57 Posts Joined Oct 2023
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If you want to join a team making pathogen sequencing and analysis for public health, surveillance, and research more accessible, more equitable and more ✨awesome✨ - look no further - come join us on this mission at ARTIC!

#openscience #opendata #opensource

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HIV Research Grants (US) | Gilead The Gilead Research Scholars Program in HIV supports worldwide innovative research from emerging investigators. Learn more about the program.

Please share with junior faculty working on HIV/AIDS cure topics: researchscholars.gilead.com/hiv_us/about

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RNA-specific local translation is patterned by condensates for multinucleate cell growth - Nature Cell Biology Geisterfer, Jalihal et al. show spatially distinct effects of Whi3 condensates on target translation in Ashbya syncytia. In vitro, translation is enriched at condensate–solute interfaces but repressed...

Condensates are powerful ways to break symmetry and cells do remarkable things with them. Here we show that in a multinucleate fungus, a condensate regulates translation of a cyclin and a formin in distinct locations.
www.nature.com/articles/s41...

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Deep untargeted wastewater metagenomic sequencing from sewersheds across the United States Wastewater monitoring enables non-invasive, population-scale tracking of community infections independent of healthcare-seeking behavior and clinical diagnosis. Metagenomic sequencing extends this cap...

Happy to report that we submitted a new manuscript this week.

The manuscript is abour our work untargeting wastewater sequencing as a technique for monitoring viral pathogens from wastewater. @lennijusten.bsky.social
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medrxiv.org/cgi/content/...

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Ughhhhh

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Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

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Figure 1. Cryo-EM of abundant protein complexes in native membranes. Figure 2. Cryo-EM of membrane proteins in vesicles. Figure 3. 3D reconstruction of V-ATPase in native synaptic vesicle membranes. Figure 4. Generation of membrane vesicles for structure determination of proteins in their native lipid bilayer.

I've written a review on what I think is an extremely exciting direction in cryo-EM:

Cryo-EM of endogenous membrane proteins in their native lipid bilayer

Open access in Quarterly Reviews of Biophysics:
doi.org/10.1017/S003...

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🚨VIROLOGY GRADUATE STUDENTS 🚨 Are you looking for a postdoc? We have a webinar Just for you We hope you come | American Society for Virology 🚨VIROLOGY GRADUATE STUDENTS 🚨 Are you looking for a postdoc? We have a webinar Just for you We hope you come

Thinking about a #virology #postdoc in academia, industry, or government?

Register now for @amersocvirology.bsky.social #ASV365 webinar on finding the right fit for your postdoc!

Register: albany.zoom.us/webinar/regi...

Fill out our presurvey with your questions: forms.gle/TzK73NUWRUqZ...

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Meet UW-Madison’s Brian Fox “Brian looks for enzymes that have evolved to harness them for new, industrial uses, like the deconstruction of biomass for use in biorenewable chemicals and fuels. The resulting discoveries will allow for sustainable alternatives through processes already partially optimized by nature.”

"Brian looks for enzymes that have evolved to harness them for new, industrial uses, like the deconstruction of biomass for use in biorenewable chemicals and fuels," says Jennifer Gottwald, WARF director of licensing.

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It is a great sadness to hear of Robin’s passing.

He was one of the finest virologists of all time and contributed immeasurably to the field of HIV/retrovirology.

He was a key mentor for a vast number of leading virologists and cancer researchers. And great fun!

So many of us owe him our careers

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Congrats, Ahna!

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a headshot of David Botstein

We are deeply saddened to share the news of the passing of David Botstein, a towering figure in modern #genetics and a foundational force behind SGD.
www.yeastgenome.org/blog/in-memo... #yeast #modelOrganism

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Best wishes to Cancer Biology gradaute student Zach Kauffman (Lang lab) as he defends his dissertation this week!

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See you next Saturday, Pittsburgh!

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RNA Splicing Lab - JOIN US Are you interested in investigating basic mechanisms in splicing regulation and gene expression? Our research group was launched in September 2024 and is hosted at the Institute of Molecular Infection...

We have an open position for a #PhD student (last week to apply!) & a lab technician/TA. For more information see: www.beuschlab.org/join-us
Interested in understanding post-transcriptional regulation and how #RNA #splicing decisions are made? Then take a look or share with people who might be! 🧪🧫

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Most viruses rely on the host to provide the entire translation machinery. However, giant viruses have evolved to encode part of the machinery themselves. Latest discovery: mimivirus (APMV) encodes its own initiation factor (vIF4F) and specifically promotes translation of viral mRNA!

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A line graph showing NSF grant awards made through 2/27/26 for fiscal year 2026 compared with grant awards for fiscal years 2021-2025.

NSF Update (Awards through 2/27/26)

Directorates to follow

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Nodavirus protein A's interdomain elbow controls RNA replication organelle formation and function pubmed.ncbi.nlm.nih.gov/41755640/ #cryoEM

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Postbac positions available in experimental and computational biology working on #virusevolution, tick-borne viruses and computational drug discovery! Reach out if you’d like to discuss projects in the #QVEU at NIH-NIAID. Please share with any talented undergrads or MS students you know!

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White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

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I had to renegotiate my F99/K00 award twice in 6 months, and on both occasions I asked what specifically “DEI activities” means. I didn’t get clear answers, so I was hopeful the person that directive came from could specify (the NIH Director). I asked the on @whyshoulditrustyou.bsky.social podcast

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If you want a science cleanse today, read and celebrate the accomplishments of these amazing young scientists

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JCI Insight - Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb coinfection in macaques

New paper in insight.jci.org by my & Ling Lin’s groups! TB is the most common infectious disease that causes death, causing >1 million deaths globally. HIV is the greatest risk factor for TB, causing worse clinical outcomes for both infections. We studied the effect of SIV infection 1/4

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Already time for the next Maxigroup! Can't wait to host @oawlab.bsky.social to talk about mechanisms and therapies related to splicing & cancer! Next Tues, March 3 at 5:30pm! Thanks to @bmolchem.bsky.social @uwbiochem.bsky.social the CMB program and @rnasociety.bsky.social for sponsorship!

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Senior Scientist, Protein Sciences in South San Francisco, California, United States of America | Research & Development at Genentech Apply for Senior Scientist, Protein Sciences job with Genentech in South San Francisco, California, United States of America. Research & Development at Genentech

Our department at Genentech is hiring. We're looking for a freshly-minted PhD (0-3 years) protein biochemist / structural biologist to join as a Sr Scientist. A rare opportunity to join our group leader job family at a more junior level than we usually hire.

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In academic depts, ‘jobs’ for many folks increased manifold in the past 15 months with no pay increases. They talk to your trainees & junior colleagues and talk them off high ledges. They organize and fight for the greater good.

Find them. Celebrate them. Reward them.

Don’t take them for granted.

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Integrase anchors viral RNA to the HIV-1 capsid interior - Nature HIV-1 integrase forms an RNA-binding module on the luminal side of the mature capsid lattice.

Nature research paper: Integrase anchors viral RNA to the HIV-1 capsid interior

go.nature.com/3OlzcfC

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Subacute sclerosing panencephalitis (SSPE) is one of the delayed complications of measles and affects up to 1 in 600 unvaccinated children who’ve had measles. It occurs without warning an average of 7 years after infection and can occur decades later. There is no cure and it is almost always fatal.

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I and my USG colleagues would go to external meetings where lunch would be served and to follow the rules we had to pay for our sandwiches.

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