Steve Reilly

#ASHG2025 is underway and it's broken the record for the world's largest #genetics conference!

As a member of the program committee (@sgrayg.bsky.social), we'd like to thank everyone at @geneticssociety.bsky.social for making this possible. We can't wait to see what the next few days hold... 🧬🤝

Human Genome Sciences The overall goal of the Human Genome Sciences (HGS) track is to train the next generation of scientists in the areas of human genomics, genetics, and

Yale has established a new PhD program in Human Genome Sciences and will be accepting applications this fall. We are also searching for an Associate Director of Student Services (a PhD-level position).

Learn more here:
medicine.yale.edu/bbs/tracks/h...

careers.yale.edu/us/en/job/YU...

After spending tons of time rebutting our trainee's grant termination.. this response doesn't suggest a 'careful assessment'

There aren't mechanisms that support mid-PhD trainees, so theres nothing to apply to, even though it scored in the top % of all apps.
Not to mention the demotivation.
Ugh.

🧠 MPRA + AI to decipher rules of enhancer grammar.

I wrote some thoughts about the fantastic and inspiring work by Robert Frömel & colleagues from @larsplus.bsky.social lab at @crg.eu @upf.edu 👏👏👏

sciencemediacentre.es/en/design-dn...

A letter from Jeremy Berg to NIH Director Jayanta Bhattacharya about the need to award grants promptly.

As a follow-up to the Kaiser interview, here is my exchange with Dr. Bhattacharya starting Sunday evening...

1/n

Proud to share our lab’s first student preprint!🚀@j-c-butts.bsky.social, @alwaysrong.bsky.social, @sagergosai.bsky.social leveraged our MPRA models to predict variant effects, providing scores for the complete catalog of human variation. Grateful for another fun collab with @stevereilly.bsky.social.

20% of the US population is rural, but certainly not 20% of scientists are. Not fostering scientists from these places certainly DOES reduce our knowledge, reduces our health, and reduces scientific inquiry.

OOF.

"Research based on artificial and non-scientific categories, including amorphous equity objectives, are antithetical to the scientific inquiry, do nothing to expand our knowledge of living systems, provide low returns on investment, and do not enhance health, lengthen life, or reduce illness"

To add insult to injury, the termination letter reads like the free version of chatGPT imitating a nut job, not a piece of official US correspondence:

This student went against the odds to make it where he is, leaning on his brilliance and tenacity. He moved to WI and attended UW-Madison.
Would love to hear from #repgusbilirakis @baldwin.senate.gov #ronjohnson about how defunding the brightest young scientists from rural America makes us great?

The work was going to better understand how evolutionary pressures in people's ancestry altered their risk for disease. It was helping to make the promise of precision genetic medicine a reality. It was at the forefront of global biomedical research, now quickly being ceded to Europe and China.

a man holding a cup of coffee with the words it 's horrible written on his face ALT: a man holding a cup of coffee with the words it 's horrible written on his face

Incredibly frustrated today that we had a PhD trainee's NIH grant TERMINATED. He EARNED it by scoring in the top %.

Would love to hear from #murkowski @sendansullivan.bsky.social
@nickbegich.bsky.social think about a bright AK native son's prospects getting cut short due to DOGE lunacy.

Thanks #MITS2025 for inviting me to speak about our deep learning-based search for variants under positive selection in the human genome; more to come! @pardissabeti.bsky.social @stevereilly.bsky.social

the word alert is in a purple circle ALT: the word alert is in a purple circle

ACTION ITEM-----ACTION ITEM

Implementation of Schedule F

This is what a lot of us have been worried about.

This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs.

BUT THERE IS A COMMENT PERIOD...

1/n

Read through to see our new collaborative work predicting the effects of regulatory variation, for complex traits, rare disease, cancer, and evolution by making ML models of MPRA and scaling to the entire genome.

Hello Bluesky. The Reilly lab fully made the jump from twitter. Thought it was time to say hello, so: hello!

Excited to join a great community of scientists here!