Nico Claassens

ACS Synthetic Biology We introduce MOSAIC, a highly efficient protocol for the editing of plasmids and generation of combinatorial plasmid libraries. This quick protocol employs the single-stranded DNA annealing protein Cs...

Great to see our MOSAIC story about an easy, cloning-free efficient protocol for mutating plasmids using recombineering is out now officially and the cover story of ASC Synthetic Biology pubs.acs.org/toc/asbcd6/1... ! Great shoutout to Marijn van den Brink, Tim Althuis and Christophe Danelon!

In my left hand I am holding the package of the 'hey mela' pregnancy test. The first vegan pregnancy test in the world. Now available in Germany.

'hey mela' is the first vegan pregnancy test in the world. Now available in Germany.

What could be vegan about it?

These tests are based on antibodies that are usually farmed from small rodents kept in cages, infected with hybridoma cells.

This test is based on AB expressed from algae!! 🧪

Congratulations Gerrich!

Gefeliciteerd!!

Congratulations!! Great to see this one out Thomas, Pierre and others!!

Archaeal Virus Ph.D. project! (With Tessa Quax)
www.rug.nl/about-ug/wor...

Please repost!

Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!

Location: DTU Biosustain

🦠🧬🔬

Starting in 01/2026!

Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

Fijn dat het deze verkiezingen een keer over belastingen gaat.
Nu nog zorgen dat de feiten het winnen van de framing.

De middenklasse in NL betaalt de belastingkortingen van de allerrijksten. Hoe rijker je bent, hoe lager je belastingdruk.

Dit komt door politieke keuzes. Ga stemmen 29 oktober.

And once promising stuff seems to happen clean streak some colonies, test and sequence (you can also sequence population) but clean streaked colonies is neater usually

Sounds like a good plan to keep it simple and start like that, worked often well for us. Try to see maybe based on limited intermediate OD checks (glass tubes that fit in spectrophotometer can be convenient) if strain already speeds up, so you can see soon enough if better strains take over the pop.

The Escherichia coli replication initiator DnaA is titrated on the chromosome - Nature Communications A DNA-binding protein, DnaA, regulates the initiation of chromosomal replication in bacteria. Here, Olivi et al. show that the bacterial chromosome sequesters DnaA in a growth rate-dependent manner, s...

🧵 Our study on the elusive titration control mechanism of the replication initiator DnaA in Escherichia coli is now out on @natcomms.nature.com‬! @stephkoe.bsky.social
@hohlbeinlab.bsky.social‬ @nicoc-micsynmet.bsky.social @ettema.bsky.social‬ @mib-wur.bsky.social
doi.org/10.1038/s414...

I'm going to be advertising for a few positions in my group in the next couple of months for a big project on synthetic microbial communities.

I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!

New paper from our lab on synthetic genome work in yeast is out - Iterative SCRaMbLE for Engineering Synthetic Genome Modules and Chromosomes. Exciting project led by Jane (Xinyu) Lu in our group, now online. t.co/0LuGwgAWlA

Faculty Position in Life Science Engineering The School of Life Sciences at EPFL invites applications for a faculty position in life science engineering. Appointments will be at Tenure Track Assistant Professor or at Associate Professor level. W...

Outstanding Faculty opportunity in the broad area of 'life sciences engineering' @EPFL School of Life Sciences, open to both junior and senior researchers. We may prefer metabolism-centric applications but remain open to outstanding applications across domains:
www.epfl.ch/about/workin...

De SP zelfs nog meer!

Nice enjoy, was there some years ago

Verona??

Escherichia coli selection strains for growth-coupled metabolic engineering Synthetic metabolism has the potential to transform carbon capture, bioremediation, or bioproduction strategies. To transfer metabolic designs from an…

#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.

www.sciencedirect.com/science/arti...

Proteins of amino acid metabolism form large structures and determine diffusion in the cytoplasm!

Our 7-year-long tour-de-force is now out on Bioxriv www.biorxiv.org/content/10.1...

Thanks everyone involved! And especially to Jose Losa who pioneered this!

Intriguing work Matthias and colleagues!

Congrats!!!

A line chart titled “Annual CO₂ emissions” shows the global carbon dioxide emissions from fossil fuels and industry from 1950 to 2023. The y-axis represents emissions in billions of tonnes (t), ranging from 0 to 40 billion t. The x-axis covers the years from 1950 to 2023. The chart presents a steady increase in emissions from approximately 5 billion tonnes in 1950 to over 36 billion tonnes in 2023. Key features include: A consistent upward trend from 1950 through the early 1970s. A brief plateau and dip around 1980–1983. A strong growth trend resuming in the late 1980s. A sharp increase during the 2000s. A slight drop around 2008–2009, likely due to the global financial crisis. A major dip in 2020, attributed to the COVID-19 pandemic. A rapid rebound in emissions after 2020, continuing the upward trend to a new high in 2023. A blue line labeled “World” traces these changes over time. Below the chart, the data source is listed as the Global Carbon Budget (2024), and the graphic is credited to OurWorldInData.org with a Creative Commons license (CC BY). A footnote explains that the data includes emissions from coal, oil, gas, flaring, cement, and steel, but excludes land-use changes such as deforestation.

I get annoyed at the narrative that all the awareness and work on climate change hasn't done anything. Yes, global CO₂ emissions indeed continue to climb, but we don't know the counterfactual. When I was in grad school, we were on track for 5°C of warming. Now it's below 3°C. That's progress.

For topic number 4 Chris Voight, and for topic one maybe somebody related to the company Neoplants

Thanks most credits to @beaubd.bsky.social !!

Bachelor open avond Wageningen Universiteit: 5 juni van 16-21h

www.wur.nl/nl/onderwijs...

New vacancy in my team!

PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.

Please repost and share with talented MSc students in #evobio, bioinformatics or related :)

www.uu.nl/en/organisat...

#MEvoSky #MicroSky

Very nice lab to do a PhD

Teken voor een motie van wantrouwen tegen minister Faber De ondertekenaars van deze petitie laten zien dat het Nederlandse volk klaar is met een minister die de hand boven het hoofd gehouden wordt om de coalitie bij elkaar te houden. Dit terwijl de minister...

Ik vind deze campagne erg belangrijk - doe je ook mee? actie.degoedezaak.org/petitions/mo...

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs.

Plant, Bacterial, Archaeal Non-model Bioeng
Custom Lab Hardware
Turn Key Genetic Design

Please repost for reach 💚

>4 megabase synthetic genome assembled in E.coli with 7 of life's 64 codons removed throughout. A new landmark for synthetic genomes. I wonder how well this little cell grows...