Nick Chavkin

Molecular & Cellular Physiology (MCP) Monday

We are recruiting a tenure-track assistant professor to join the Dept of Molecular & Cellular Physiology at Stanford. Apply to be our colleague 1/n
facultypositions.stanford.edu/en-us/job/49...

#Senescence #Mechanobiology

Senescent #EndothelialCell HUVEC (+H2O2 or Doxorubicin) have ⬆️ #Viscoelasticity
(Microfluidic cytometric measurement of suspended whole-cell deformation)

⏫F-actin, Calnexin ER, Lamin A Nuclear envelope

#CellRepPhysSci 2025
www.sciencedirect.com/science/arti...

The New England Journal of Medicine Mavacamten in Nonobstructive Hypertrophic Cardiomyopathy A Research Summary based on Desai MY et al. | 10.1056/NEJMoa2505927 | Published on August 30, 2025 Visual representations of the patients in the trial and the treatments they were assigned. Read the full Research Summary at NEJM.org.

In patients with nonobstructive HCM, mavacamten did not significantly improve peak oxygen uptake or decrease symptoms as compared with placebo, and more patients had a reduction in LVEF with mavacamten. Full ODYSSEY-HCM phase 3 trial results and Research Summary: nej.md/4oSZx2m

#MedSky

The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative Nature Reviews Cardiology, Published online: 12 September 2025; doi:10.1038/s41569-025-01209-zIn this Review, Khoury and colleagues examine the growing body of evidence demonstrating the benefits of screening for cardiovascular risk factors, including dyslipidaemia and high blood pressure, starting in childhood to reduce the lifetime burden of cardiovascular disease.

New online! The prevention of adult cardiovascular disease must begin in childhood: evidence and imperative #CardioSky

Natural medicines target tumor vascular microenvironment to inhibit cancer growth

www.sciencedirect.com/science/arti...

G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration Boraas et al. identify that mRNAs and the stress granule RNA-binding protein G3BP1 form ribonucleoprotein (RNP) complexes at FAs. These RNPs regulate FA protein mobility and cell migration under norma...

Check out how mRNA can influence cell motility! See how here: www.cell.com/cell-reports.... Thanks for the shout-out Yale News and @cp-trendscellbio.bsky.social!

news.yale.edu/2025/02/13/f...

www.cell.com/trends/cell-...

Microvascular Rarefaction in the Sinoatrial Node: A Potential Mechanism for Pacemaker Dysfunction in Early HFpEF

Manning & Rivera et al. (www.jacc.org/doi/10.1016/...) show that pruning just a few capillaries in the SA node plunges the heart’s pacemaker into metabolic overdraft—slowing the rate and jacking up beat-to-beat variability. The physiological equivalent of running on fumes. @jaccjournals.bsky.social

❤️Our July issue is out❤️Discover an Angiopoietin-TIE2-dependent circuit promoting venous malformations, complex disease modelling in cardiac organoids, regulation of cardiac homeostasis by methyonil tRNA synthetase, and more!

www.nature.com/natcardiovas...

Excited to share a recent review article that I published on Cardiovascular Aging and Hematopoietic Mosaic Loss of Y Chromosome. Main take-home: there are strong similarities between loss of Y and aging in clinical correlations and disease progression.
www.oaepublish.com/articles/jca...

Researchers in a lab. Text reads Seattle Children's Research Institute. Turning discoveries into lifesaving therapies. Follow Us!

Bluesky, we're here! 👋

We’re excited to connect with the growing biomedical research community here.
Follow us for groundbreaking discoveries, new insights, and research updates from Seattle Children's Research Institute. 🧬

#MedSky

#EVBOSeminarSeries Moderated by Joanna Kalucka. Speakers: Ralf Adams and Mariona Graupera. ⏰When: Wednesday, 18th June 2025, 3PM EU time (2PM UK). Place: online. See you there! For registration evbo.org

Dual mechanotherapy for the treatment of cardiac fibrosis Nature Reviews Cardiology, Published online: 19 May 2025; doi:10.1038/s41569-025-01172-9Inhibition of mechanotransduction selectively in cardiac fibrolasts, especially when combined with inhibition of transforming growth factor-β signalling, triggers a reversal of fibroblast activation and suppresses fibrosis in diseased hearts.

New online! Dual mechanotherapy for the treatment of cardiac fibrosis #CardioSky

Please join us next Tuesday April 29th at 1 pm EST for our next Symposium on Precision Genomics: CRISPR and Single-Cell Technologies in Vascular Biology, featuring #AaronJames @bgcoonlab.bsky.social @chadweldy.bsky.social and moderated by @vsleekim.bsky.social !
Register here: tinyurl.com/yhcdr68a

Seminar presentation

4 ppl having dinner

Big thanks to Karen Hirschi for the great presentation and for visiting us in Toronto! We really appreciated the insights and the chance to connect in person.
@medicinebydesign.bsky.social @uhnresearch.bsky.social

@lukedunaway.bsky.social, PhD, recently received an @americanheart.bsky.social Career Development Award to study iron's role in chronic kidney disease. Luke is a postdoc in @brantisakson.bsky.social's Lab and member of our Cardiovascular Training Program. Congratulations!

#CardioSky #MedSky

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium Nature - Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result...

If you’re curious about why lymphatic endothelial cells have their jigsaw puzzle-like shape,
check out our paper
@Nature
rdcu.be/eejhZ

Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives
A scientific statement of the #HFA of @escardio.bsky.social

onlinelibrary.wiley.com/doi/full/10.... @shelleyzieroth.bsky.social @cardioobdoc.bsky.social @drrajivsankar.bsky.social #CardioSky

Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find distinct vascular alterations in IDH mutant gliomas, IDH WT…

Online now: Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors

BREAKING: NIH admits funding freeze is illegal, will resume issuing grants An internal memo issued February 12 was obtained by Popular Information.

"NIH admit freezing is illegal, will resume issuing grants"

popular.info/p/breaking-n...

Hello from the Yale Cardiovascular Research Center! We look forward to interacting with the science community on blue sky!

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction - Cell Death & Disease Cell Death & Disease - Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction

New study shows that genomic instability promotes brain endothelial cell aging and impairs brain homeostasis doi.org/10.1038/s414... #cerebrovascular

Mosaic pattern loss of Y chromosome, which occurs in ~40% of men by age 70, is causally linked to heightened risk of many diseases, including cardiovascular, bladder cancer, and Alzheimer's. But it's almost never assessed clinically.
A new review
nature.com/articles/s41...

Frontiers | Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling

Member publication alert:

Monocyte adhesion to and transmigration through endothelium following cardiopulmonary bypass shearing is mediated by IL-8 signaling

www.frontiersin.org/journals/car...

Scientists, academics, researchers: We’re excited to share that @altmetric.com is now tracking mentions of your research on Bluesky! 🧪

Here's a starter pack focusing on cardiovascular research.
I'm sure the pack is incomplete. If you'd like to be added to the list, please let me know!

go.bsky.app/SgaGkv5

What cell types drive congenital heart defects (CHD)?

Some new answers in our latest preprint, where we explored:
1). Key cell types contributing to CHD genetics
2). Impact of noncoding variants on CHD risk

https://www.medrxiv.org/content/10.1101/2024.11.20.24317557v1

Terrific first paper from the Liu's lab on the role of CXCL12/CXCR4 signaling in the lymphatic vasculature (and also they got the cover)! Congratulations Xiaolei and many more papers to come

journals.biologists.com/dev/article-...

Call for papers on "Special Technologies in Omics of the Cardiovascular System" for AJP Heart Circ

I am excited to share this call for papers for AJP Heart & Circulatory Physiology on Technologies in Omics of the Cardiovascular System. Please share with your networks.
journals.physiology.org/ajpheart/cfp...