TNM-Lab

🧠Out now @natcomms.nature.com !
Brain changes linked to childhood maltreatment are among the field's most published findings. Yet, we find extensive replication failure of gray matter correlates in three large cohorts (N=3225), consistent across subsamples, models and operationalizations🧵

The CRC/TRR 393 aims to unravel trajectories of depression & bipolar disorder by combining mobile assessments, neuroimaging, -omics & interventions in >1500 participants.

A 12-year effort to decode mechanisms of recurrence & remission.

Overview:
🔗 rdcu.be/eGtBy

🥳 Our study led by @edwardody.bsky.social from the @tnm-lab.bsky.social is published in the European Journal of Neuroscience. Take a look if you are interested in action-perception transition, readiness potential, and voluntariness of action!

📍https://onlinelibrary.wiley.com/doi/10.1111/ejn.70236

Neural correlates of human fear conditioning and sources of variability in 2199 individuals - Nature Communications A large brain imaging study of over 2000 people worldwide shows that fear conditioning engages brain regions linked to emotion and attention, with differences in individuals with anxiety or depression...

Neural correlates of human fear conditioning and sources of variability in 2199 individuals
www.nature.com/articles/s41...

Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder - Schizophrenia Schizophrenia - Temporal characteristics of hemodynamic responses during active and passive hand movements in schizophrenia spectrum disorder

🧠 New paper out!
Rashid, Kircher & Straube (2025) investigate temporal characteristics of hemodynamic responses during active vs. passive hand movements in schizophrenia spectrum disorder.

📄 Schizophrenia:
👉 doi.org/10.1038/s415...

Kausalitätswahrnehmung, Erwartungen & psychische Gesundheit begeistern dich?
Bewirb dich auf die Promotionsstelle (3 Jahre, 75%) in Marburg (www.theadaptivemind.de) bis zum 17.08.:
stellenangebote.uni-marburg.de/jobposting/1...
#Job #Promotion #fMRI #Psychologie

🧠🗣️ I’m co-editing a Neuropsychologia Special Issue:
“Language in Psychosis – A Multidisciplinary Approach”

We welcome contributions on:
• neural mechanisms
• predictive processing
• cognitive, computational & clinical perspectives

📅 Deadline: Sept 30, 2025 www.sciencedirect.com/special-issu...

Delay adaptation does not transfer between discrete button press actions and continuous control - Loes CJ van Dam, Svenja Kernig, Karina Lazarova, Melisa Ünal, Nicole Gappa, Benjamin Straube, Thomas S... When interacting with technology, humans often deal with delays between an action and the desired action outcome. Through delay adaptation these delays will bec...

Delay adaptation does not transfer between discrete button press actions and continuous control - Loes CJ van Dam, Svenja Kernig, Karina Lazarova, Melisa Ünal, Nicole Gappa, Benjamin Straube, Thomas SA Wallis, 2025 journals.sagepub.com/doi/10.1177/... @tsawallis.bsky.social

Transcranial direct current stimulation alleviates the negative impact of immediate and chronic social exclusion on intertemporal decision-making Abstract. Social exclusion impairs decision-making, affecting social functioning. This study examines how social exclusion, in both immediate, experimental

Feeling excluded can distort your decisions!

New study shows tDCS can buffer against the effects of social exclusion on decision-making.

🔗 academic.oup.com/scan/advance...
#neuroscience #tDCS #socialexclusion #mentalhealth

New manuscript! Together with Junqing Huang & @straubeb.bsky.social, we used an innovative paradigm & DDM to show that gesture's processing hierarchy from a behavioral perspective!

Gestures are visual—but they’re also layered, structured, and unfold like language. 🧠🖐️

👇👇👇
osf.io/r5nb9_v1

#science #clustersofexcellence #exstra #excellence #germany #psychology… | Roland Fleming | 12 comments It's funded! 🎉 YES! Our proposal for an Excellence Cluster, "The Adaptive Mind" (TAM) is among 70 projects across all Germany and all disciplines that will receive funding for 7 years, ...

www.linkedin.com/posts/roland...

Map of Germany with the Clusters of Excellence

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

Aberrant preparation of hand movement in schizophrenia spectrum disorder: an fMRI study Rashid et al. investigated preparatory neural processes in schizophrenia spectrum disorder (SSD) during active and passive hand movements using functional

🧠✨ New publication in Brain Communications!
Schizophrenia spectrum disorders & motor preparation:
Aberrant pre-movement fMRI patterns in insula, putamen, cerebellum & angular gyrus
🔗 doi.org/10.1093/brai...
#Schizophrenia #fMRI #ActionAwareness #CognitiveNeuroscience #Psychiatry

Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome - Molecular Psychiatry Molecular Psychiatry - Epigenetic markers of disease risk and psychotherapy response in anxiety disorders – a longitudinal analysis of the DNA methylome

🚨 New in Molecular Psychiatry 🚨
DNA methylation as a potential marker for anxiety disorders & psychotherapy response:
Longitudinal EWAS reveals epigenetic signatures linked to disease risk and CBT outcomes.
📖 doi.org/10.1038/s413...
#Anxiety #Epigenetics #CBT #Psychiatry #PrecisionMedicine

Join the #SFBTRR393 in Marburg! Two open PhD positions (65%) in A04, investigating inflection signals in #depression using MRI, EMA & EEG. You’re passionate about translational #psychiatry and want to work in an interdisciplinary environment? Apply by April 27 via the official portal ⬇️ #ResearchJob

Choice- and trial-history effects on causality perception in Schizophrenia Spectrum Disorder - Schizophrenia Schizophrenia - Choice- and trial-history effects on causality perception in Schizophrenia Spectrum Disorder

How do patients with schizophrenia Spectrum Disorder perceive causality? We show altered reliance on spatial vs. temporal cues—and a growing bias to repeat prior choices over time.
➡️ doi.org/10.1038/s415...
#Schizophrenia #Perception #Cognition #Neuroscience

And here the poster!

If you are at #CNS2025, check out this brilliant poster #F98 from @edwardody.bsky.social @straubeb.bsky.social where we probed for action-specific "quasi-predictive" effect independent of probability-based expectations!

Group photo of the SFB/TRR 393 team in front of Rauischholzhausen Manor.

Hi! We are the SFB/TRR 393 "Trajectories of Affective Disorders: Cognitive-Emotional Mechanisms of Symptom Change" - a transregional @dfg.de collaborative research center & interdisciplinary team of researchers working together to better understand what influences the course of affective disorders👇🏻🧵

Predictive neural processing of self-generated hand and tool actions in patients with schizophrenia spectrum disorders and healthy individuals - Translational Psychiatry Translational Psychiatry - Predictive neural processing of self-generated hand and tool actions in patients with schizophrenia spectrum disorders and healthy individuals

Patients with schizophrenia spectrum disorders show reduced differentiation between self- and externally generated sensory input, particularly during tool use and bimodal feedback.
🔗Read more: www.nature.com/articles/s41... #Neuroimaging #Schizophrenia #PredictiveCoding #fMRI @cschmitter.bsky.social

New paper about “Predictive neural processing of self-generated hand and tool actions in patients with schizophrenia spectrum disorders” has been accepted for publication in Translational Psychiatry! Congratulations Christina

Schmitter, C.V., Pazen, M., Uhlmann, U., van Kemenade, B.M., Kircher,…

Modelling sensory attenuation as Bayesian causal inference across two datasets Introduction To interact with the environment, it is crucial to distinguish between sensory information that is externally generated and inputs that are self-generated. The sensory consequences of one...

#PLOSONE: Modelling sensory attenuation as Bayesian causal inference across two datasets dx.plos.org/10.1371/jour... Congratulations @eckertal.bsky.social

📢 Stellenausschreibung im TNM-Lab: Qualifizierungsstelle (65%) mit Promotionsziel im SFB/TRR 393 an der Philipps-Universität Marburg. Forschung zu affektiven Störungen mit modernster Ausstattung (MRT, EEG). Bewerbungsfrist: 02.02.2025. stellenangebote.uni-marburg.de/jobposting/f...

Advancing the personalized advantage index (PAI): a systematic review and application in two large multi-site samples in anxiety disorders | Psychological Medicine | Cambridge Core - www.cambridge.org/core/journal...

Voluntary action sharpens sensory prediction and facilitates neural processing of contingent sensory stimuli Self- and externally generated sensations differ in sensory responses and motor preparation. However, mechanistic evidence linking the two is scarce. Here, participants made active (self-initiated) or...

Proud to debut in BlueSky with a fascinating new preprint from @tnm-lab.bsky.social @straubeb.bsky.social led by Edd Ody, where we used MVPA of EEG to show how motor preparation and sensory perception are related in action-effect contingency.

🔗https://shorturl.at/XZp5q

🧵👇

🧵1) Participants made active (self-initiated) or passive (finger moved by electromagnet) movements triggering bimodal auditory/visual stimuli. They were followed, in a block-wise manner, by unimodal auditory/visual comparison stimuli, and participants judged which stimulus was brighter or louder.

🧵2) We looked at the EEG around the bimodal stimuli. Univariate ERP shows that RP differed between movements and task modalities, but did not show any interaction (A-B). Sensory VEP suggests a clear active suppression: the modality difference was reduced in the active movement.

🧵3) We then decoded task modality. In motor preparation, active showed higher decoding accuracy than passive, suggesting enhance prediction. But in the perception time window, decoding accuracy was lower in the active condition, suggesting less difference between modalities (again suppression).

🧵4) We then did temporal generalization. Here, broadband EEG did not show pattern similarity between both time windows. But the neural pattern was similar when we looked at the alpha amplitude. By-subject correlation also suggests positive correlation between both windows in the alpha band.

🧵5) Our data thus shows that voluntary (vs. passive) movement shows enhanced prediction during motor preparation and suppressed neural processing of their sensory outcome (in terms of modality). Also, alpha oscillations may directly mediate motor preparation and sensory perception.