ADLab

A Comparative Study of ¹⁵⁷Gd and ¹⁰B Effect in a Carborane-Based Theranostic Agent for Membrane-Targeted Carbonic Anhydrase IX Inhibition and MRI-Guided Neutron Capture Therapy in Mesothelioma Treatment This study investigates combined gadolinium and boron neutron capture therapy (GdBNCT) with carbonic anhydrase IX (CA IX) inhibition for mesothelioma treatment using a multifunctional platform (Gd-B-CA-SF). This platform incorporates a carborane cage for BNCT, a Gd complex for GdNCT/MRI, and a sulfamido group for CA IX inhibition. In vitro studies confirmed CA IX inhibition and selective binding of the compound to AB22 mesothelioma cells, with a 10-fold higher boron uptake compared to that in healthy Met-5a mesothelium. The combination of B and Gd in one molecule allows the exploration of potential additional effects coming from the nuclides 10B and 157Gd. Irradiation of AB22 cells showed complete tumor regrowth inhibition after treatment with 157Gd-10B-CA-SF, an effect strictly related to the presence of 157Gd and its localization on the cytosolic membrane. In vivo MRI studies confirmed higher accumulation of Gd-B-CA-SF in AB22 tumors in mice, demonstrating effective targeting. In vivo NCT experiments showed reduced tumor growth in 157Gd-10B-CA-SF treated mice, confirming the effectiveness of both 157Gd and 10B, even at relatively low concentrations. These results demonstrate the translational potential of Gd-B-CA-SF as a theranostic agent for an innovative approach to cancer treatment.

Big milestone for our group! 🚀
Our latest ACS Central Science paper unveils a ¹⁰B/¹⁵⁷Gd hybrid theranostic for MRI-guided neutron capture therapy in mesothelioma: merging chemistry and biotechnology for next-gen, image-guided cancer treatment

🔗 pubs.acs.org/doi/10.1021/...

31.10.2025 10:30 — 👍 0    🔁 0    💬 0    📌 0

New paper out in Advanced Synthesis & Catalysis!
We found another way to expand the use of the photoactive diarylmethylium tetrafluoroborate salts for photochemical transformations 🔦🧪

Check it out 👉 advanced.onlinelibrary.wiley.com/doi/full/10....

30.10.2025 08:40 — 👍 0    🔁 0    💬 0    📌 0

This week, our group members Marco and Alberto attended Euroboron10 in the warm city of Łódź, where they showcased our latest research on photoinduced B-H activation of carboranes and on BNCT in the treatment of Alzheimer’s disease. #Euroboron10 #Photochemistry #BNCT #Alzheimer #Carboranes

11.07.2025 20:51 — 👍 0    🔁 0    💬 0    📌 0

Synthetic Methodologies to Access Skipped Dienes: A Focus on the Catalytic Systems 1,4-Dienes, also known as skipped dienes, are widely diffused in natural products and serve as valuable synthetic intermediates. However, their synthesis continues to pose a substantial challenge. In ...

New publication of our group on Organic & Biomolecular Chemistry on recent protocols for the synthesis of skipped dienes

pubs.rsc.org/en/Content/A...

30.05.2025 11:44 — 👍 1    🔁 1    💬 0    📌 0

Light‐Induced Domino and Multicomponent Reactions: How to Reach Molecular Complexity without a Catalyst Is it possible to build up molecular complexity without the help of a catalyst? Yes, it is! With the suitable starting-materials, a domino or multicomponent reaction can be initiated just turning on ...

Our work, published in #Eurjoc in 2023 has ranked within the top 10% of most-viewed papers
Light‐Induced Domino and Multicomponent Reactions: How to Reach Molecular Complexity without a Catalyst
@wiley.com @chemistryeurope.bsky.social
chemistry-europe.onlinelibrary.wiley.com/doi/full/10....

16.04.2025 12:36 — 👍 4    🔁 1    💬 0    📌 0

Purple‐Light Promoted Thiol‐ene Reaction of Alkenes Here we present a catalyst-free protocol for the purple light-mediated anti-Markovnikov functionalization of alkenes with thiols. Crucial to the generation of the thiyl radical was the formation of a...

We are delighted to share our work, published in Advanced Synthesis & Catalysis, has ranked within the top 10% of most-viewed papers published in 2023*:
Purple‐Light Promoted Thiol‐ene Reaction of Alkenes
advanced.onlinelibrary.wiley.com/doi/full/10....

16.04.2025 12:27 — 👍 0    🔁 0    💬 0    📌 0

Last picture of BNCT group with Lucia Pazderová after 1 year with us. Sebastiano and Marco are also ready to join the Hiroyuki Nakamura (Tokyo Institute of Technology) and Dr. John Molloy (Max Planck Institute of Colloids and Interfaces of Potsdam) research group. Good luck to everyones!

07.04.2025 13:20 — 👍 1    🔁 0    💬 0    📌 0

Our students, Jacopo Scarfiello and Marco Rusconi, presented their annual research activities during the PhD Days in Turin, alongside other students from the "Photoinduced Processes and Technologies" program. Heartfelt thanks to the organizing committee for hosting participants from all over Italy.

27.02.2025 14:08 — 👍 1    🔁 0    💬 0    📌 0

Very good news for ADLad, Compagnia San Paolo just funded our project on the application of BNCT for the treatment of Alzheimer be the use of curcuminoid derivatives, in collaboration with prof. Simonetta Geninatti Crich (University of Turin) and Prof. Nicoletta Protti (University of Pavia)

11.01.2025 10:30 — 👍 1    🔁 0    💬 0    📌 0