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Physical Biology of Developing Systems

@pbodslab.bsky.social

We are located at @mcmasteruniversity.bsky.social McMaster University Biology/Physics departments studying early vertebrate embryo patterning with quantitative tools! www.physicalbiology.ca posts by M. Fethullah Simsek.

135 Followers  |  157 Following  |  34 Posts  |  Joined: 28.11.2024  |  1.6937

Latest posts by pbodslab.bsky.social on Bluesky

Really cool experiments to solve a developmental mystery! πŸ‘πŸ»I see how torque arises, but where does the chirality come from? Why are they whirling counter clockwise as seen from dorsal? Sorry didn't dig the preprint yet..

21.07.2025 04:04 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

If you can combine with a controlled (in space and/or time) chemokine signal, would be interesting to see how to win the tug of war with optogenetic pulses...

19.07.2025 19:04 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I was seeing those in clouds frequently when doing drug induced somite experiments πŸ™ƒ

19.07.2025 16:34 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

CIHR rant here: our panel funded 6 (!!) out of 42 applications. That is only 14% success rate. That is as bad as the worst of times. So much good science left unfunded, labs closing, skilled workers let go. Without a $$ infusion, the Canadian research ecosystem is never going to survive and thrive.

17.07.2025 19:44 β€” πŸ‘ 58    πŸ” 11    πŸ’¬ 10    πŸ“Œ 1

The day which will come for every single one of us... It is interestingly different to live expecting it to come near while enjoying the legacy of what has been gifted and what awaits around the corner. With much respect and support. 🩡

11.07.2025 00:48 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Ep. 299: "Spinal Cord Development" Featuring Dr. James Briscoe - The Stem Cell Podcast Dr. James Briscoe is a Group Leader at the Francis Crick Institute and Editor-In-Chief of Development. His lab uses an interdisciplinary approach, including mice, chicks, and other models, to study de...

I was interviewed recently by @stemcellpodcast.com

I witter on about morphogens, notochord, @dev-journal.bsky.social & how biology is becoming a data science

Thanks @stemcellpodcast.com for talking to me

stemcellpodcast.com/ep-299-spina...

09.07.2025 08:00 β€” πŸ‘ 34    πŸ” 10    πŸ’¬ 2    πŸ“Œ 1

To see supplementary figure S39 which I have no idea how ended up there go to page 109!

09.07.2025 22:12 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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πŸ“£ We're on the lookout for a creative postdoc with strong computational skills!

Be the go-to person in the lab for building simple but powerful simulations that test wild ideas on biological rythems: from daily cycles of mussel groups at deep sea, to firefly flash synchronization!

More info belowπŸ‘‡

03.07.2025 01:11 β€” πŸ‘ 36    πŸ” 25    πŸ’¬ 1    πŸ“Œ 3
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Have you ever thought about inflating tissues?
Or maybe quickly deflating those inflated tissues?

New #EpithelialMechanics pre-print: doi.org/10.1101/2025...
🧡 with pressure control, multiscale buckling, controlled wrinkling

03.07.2025 14:23 β€” πŸ‘ 86    πŸ” 32    πŸ’¬ 7    πŸ“Œ 2
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Paper alert! I am really pleased to share the final version of the work led by Irène Amblard in the team on a regulatory switch controlling Cdx2 expression during posterior body development! #regulatorylogic #devbio @mrc-lms.bsky.social @imperialmed.bsky.social

27.06.2025 15:07 β€” πŸ‘ 108    πŸ” 37    πŸ’¬ 18    πŸ“Œ 3
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Self-supervised, label-free 3D cell imaging is here EPFL researchers introduce CellSeg3D, a self-supervised tool for 3D cell segmentation in fluorescence microscopy, eliminating the need for manual labeling and enhancing accessibility for various biolo...

πŸ₯° Self-supervised, label-free 3D cell imaging is here

Congrats to Cyril on this very cool first, first author publication πŸ†! This started when he was a bachelor's student (and he's now completing his masters!).

And many thanks to my other awesome co-authorsπŸ™

elifesciences.org/articles/99848

24.06.2025 17:53 β€” πŸ‘ 102    πŸ” 31    πŸ’¬ 1    πŸ“Œ 0
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Dynamic BMP signaling regulates sclerotome induction and lineage diversification in zebrafish Summary: Loss- and gain-of-function manipulations reveal that dynamic regulation of BMP signaling is essential for the induction and diversification of the sclerotome lineage in zebrafish.

Excited to share our latest work led by my PhD student Linjun Xie on sclerotome development: Dynamic BMP signaling regulates sclerotome induction and lineage diversification in zebrafish, now published on @dev-journal.bsky.social! #zebrafish #devbio 1/8 doi.org/10.1242/dev....

23.06.2025 16:42 β€” πŸ‘ 19    πŸ” 2    πŸ’¬ 2    πŸ“Œ 2

It’s out! πŸ₯³

www.science.org/doi/10.1126/...

13.06.2025 21:31 β€” πŸ‘ 18    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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πŸ”” Proud to share the preprint of my PhD work in the Petridou group @nicolettapetridou.bsky.social @embl.org ✨

β€œA closed feedback between tissue phase transitions and morphogen gradients drives patterning dynamics” 🐟 πŸ” πŸ“Ά

πŸ”— www.biorxiv.org/content/10.1...

#devbio #biophysics

🧡‡️

11.06.2025 16:47 β€” πŸ‘ 93    πŸ” 27    πŸ’¬ 3    πŸ“Œ 9

Link to the research: www.cell.com/developmenta... @cp-devcell.bsky.social

04.06.2025 01:26 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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#Science #Biologie
"Information Processing in Biological Systems"
πŸ–₯️ Les vidΓ©os colloque organisΓ© par le Pr @thomaslecuit.bsky.social, titulaire de chaire Dynamiques du vivant, sont disponibles.
πŸ‘‰ www.college-de-france.fr/fr/agenda/co...

28.05.2025 14:22 β€” πŸ‘ 13    πŸ” 4    πŸ’¬ 0    πŸ“Œ 1

Great work by @nicoleedwds.bsky.social and colleagues!

03.06.2025 00:07 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Developmental system drift in dorsoventral patterning is linked to transitions to autonomous development in Annelida https://www.biorxiv.org/content/10.1101/2025.05.29.656861v1

02.06.2025 02:31 β€” πŸ‘ 8    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Thanks for the invitation, fantastic conference out together by the organizing committee!

28.05.2025 02:07 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Canadian Developmental Biology Conference Day 3 continues - Min Zhu Postdoctoral Fellow, Hospital for Sick Children, β€œTissue stiffness mapping by light sheet elastography" #CDBC2025 @socdevbio.bsky.social

28.05.2025 00:16 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Thanks Paul, it was great to meet you in person and feel the welcoming vibes of Canadian biophysicists as well! Kudos go to @cecilefradin.bsky.social for her tremendous effort! @biophyscanada.bsky.social

23.05.2025 23:18 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Stas Shvartsman from Princeton University explains how the coupled oscillators are interesting for Physicists from Huygens apparatus in 1600s to fruit fly embryo cell divisions.

Stas Shvartsman from Princeton University explains how the coupled oscillators are interesting for Physicists from Huygens apparatus in 1600s to fruit fly embryo cell divisions.

Paul FranΓ§ois from UdeM shows BSC audience dynamic features of waddington landscape for segmentation clock in embryos.

Paul FranΓ§ois from UdeM shows BSC audience dynamic features of waddington landscape for segmentation clock in embryos.

Ahmad Mahmood from McGill Univ explains how plant pollen tubes are tweaking the physical limits to grow so quickly.

Ahmad Mahmood from McGill Univ explains how plant pollen tubes are tweaking the physical limits to grow so quickly.

Last day of #BSC2025 with fantastic developmental #biophysics talks: Ahmad Mahmood/ WisemanLab, Abby Gerhold from @mcgilluniversity.bsky.social, @pfrancois.bsky.social, @katwrog.bsky.social + keynote by Stas Shvartsman from @princetonmolbio.bsky.social #drosophila #zebrafish #celegans #plants.

23.05.2025 21:57 β€” πŸ‘ 5    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1
CΓ©cile Fradin opening the 10th BSC meeting

CΓ©cile Fradin opening the 10th BSC meeting

Very very happy to participate in the 10th Biophysical Society of Canada annual meeting ! Opening words by Cecile Fradin/ Très heureux de participer au 10e congrès de la BSC avec le
Discours Introductif de Cecile Fradin. #BSC2025

21.05.2025 12:47 β€” πŸ‘ 1    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Great #zebrafish talk on tissue biomechanics going on at the @biophyscanada.bsky.social meeting @mcmasteruniversity.bsky.social given by @manningresearch.bsky.social #bsc2025

21.05.2025 18:39 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0

H2B-iRFP713

21.05.2025 03:23 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Lovely microscopy with too many -but never enough- somites in them! 🀩

16.05.2025 03:10 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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MSc/PhD Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

Looking for MSc and PhD students to join my lab and work on vascular development in zebrafish and mouse. Feel free to share or reach out if you have questions! jobrxiv.org/job/universi...

09.05.2025 17:27 β€” πŸ‘ 6    πŸ” 8    πŸ’¬ 0    πŸ“Œ 2
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I'm excited to join @pritiagarwal.bsky.social and @tarafinegan.bsky.social as a co-organizer for the International Developmental Mechanics Seminar Series. The series will resume in September 2025, and call for speakers is now open! More info is on our new website: sites.google.com/view/devmech...

09.05.2025 03:06 β€” πŸ‘ 15    πŸ” 9    πŸ’¬ 1    πŸ“Œ 1

It was a great talk at CZRC meeting today Dmitry, thanks!

07.05.2025 02:19 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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