Surace Lab

Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression This study identifies C26 ceramide and CERS3 as critical factors in colorectal cancer progression, which is modulated by microbial metabolite riboflavin. C26 ceramide directly activates EGFR, and the ...

Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression: Cell Metabolism www.cell.com/cell-metabol...

Identification of proliferating neural progenitors in the adult human hippocampus Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into que...

Woohoo! From superstars ionut and Marta in the Frisén lab! www.science.org/doi/10.1126/... can’t wait to see what the anti-neurogenesis folks say about it 😃

The Somatic Mosaicism across Human Tissues Network - Nature The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...

Excited to share our new work in PDAC Cachexia. This work demonstrated that addition of factors like advanced age in murine models can uncover signatures that might have been obscured in other models.
Grateful for @jdoles.bsky.social ‘s mentorship and support!
Looking forward to all feedback :)

A subcellular map of translational machinery composition and regulation at the single-molecule level Millions of ribosomes are packed within mammalian cells, yet we lack tools to visualize them in toto and characterize their subcellular composition. In this study, we present ribosome expansion micros...

www.science.org/doi/10.1126/...

Tour de force by Barna Lab

@philippstrobl.bsky.social @nsssusanna.bsky.social @dhruvishah.bsky.social lina, Nehir and Ivan

I feel very lucky that science is my job… I feel even better when I think about the amazing people that I get to see everyday !
Ladies and gentleman…..The fairies 🧚🏻 from @labwilhelm.bsky.social and the fluorochromes (+ bad comp) from our @suracelab.bsky.social !

🚨 Job alert 🚨
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇

🚨 Open #position! The group of Christoph Wilhelm at the University Hospital Bonn is looking for a

Postdoctoral fellow (m/f/d) – metabolic and nutritional regulation of immunity

Application deadline is February 10!

Visit our website for more information.

#job #postdoc #science #immunology

#Immunology out now @science.org

ILC2s contribute to glucose homeostasis. Neurons that innervate the gut from areas of the brain associated with glucose sensing can stimulate ILC2s in the gut to relocate to the pancreas upon fasting.

https://buff.ly/42iBst0

🚨 Job alert 🚨
1 PhD + 1 Technician
Our lab is looking for motivated candidates interested in understanding the impact of diets and lifestyle on tumor development, anti-tumor immunity and metastasis! Apply and join our team!
Info below 👇

Effects of Aging on Glucose and Lipid Metabolism in Mice Lien et al. report a characterization of metabolism with aging across three different strains of mice. They find that glucose metabolism is robust during healthy aging; however, aging tissues exhibit....

Effects of Aging on Glucose and Lipid Metabolism in Mice

congrats @mvhlab.bsky.social !

onlinelibrary.wiley.com/doi/10.1111/...

a stack of gift boxes with the words happy boxing day below ALT: a stack of gift boxes with the words happy boxing day below

For those starting on BSKY and loving #metabolism and #mitochondria, the 2 starter packs have now been completed. 300 scientists working in this field are here to be followed! Happy Boxing Day

Starter pack 1: go.bsky.app/VavECSX

Starter pack 2: go.bsky.app/CH1MctZ

@nsssusanna.bsky.social @philippstrobl.bsky.social @dhruvishah.bsky.social and Lina

What a great year for our group! Thanks guys for your constant support, the passion and the hard work you put to bring forward our ideas and projects, and also …. for being amazing Artists&chef pâtissier!

With a photo of the latest ArtAttack, we wish everybody merry Christmas and happy new year!

#Immunology by First release now @science.org

Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection

https://buff.ly/3DjNQ1e

By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.

A very rare position for an immunology professorship at Cambridge. Something to think about!

www.jobs.cam.ac.uk/job/49381/

A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor Characterization of a common germline variant in PCSK9 unveils a hereditary basis underlying breast cancer metastasis and suggests that PCSK9 inhibition therapy could be a promising strategy for breast cancer metastasis prevention.

inherited genetic alteration governs breast cancer metastasis .. interesting work on the hereditary basis of metastasis !

www.cell.com/cell/abstrac...

Confronting risks of mirror life Broad discussion is needed to chart a path forward.

Gearing up vs the potential of building "mirror life"
A looming danger of bioengineered reversed-chirality bacteria and microbes.
www.science.org/doi/10.1126/... @science.org

Lipid-delivery system could treat life-threatening pregnancy complication Testing lipid nanoparticles for pre-eclampsia treatment.

Lipid-delivery of mRNA to placenta to treat pre-eclampsia
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Brava brava Elvira !

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia - Nature A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric d...

Wow just wow. I did not have on my bingo card an mRNA therapeutic for treating pre eclampsia. A VEGF tropic mRNA resolved maternal hypertension until pregnancy in a mouse model of the condition. Really fascinating science.
🧪
www.nature.com/articles/s41...

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

go.bsky.app/QSEPDoj

Fungal symbiont transmitted by free-living mice promotes type 2 immunity - Nature Kazachstania pintolopesii is a highly prevalent fungal symbiont that can trigger type 2 immunity and influence the composition of the gut mycobiome, as well as immune and disease phenotypes.

Fascinating new paper about how commensal #fungi can promote #type2 responses in mice, a process involving fungal induction of #IL-33 🍄 🧪 #ImmunoSky www.nature.com/articles/s41...

We are recruiting an associate or full Professor of Infection and/or Immunity to the school biological sciences in Cambridge. Full details here: www.jobs.cam.ac.uk/job/49381/
#immunology #virology