Jorge Ferrer

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins Transcription factors (TFs) bind specific DNA sequences to control gene expression. Modulating TF activity is of considerable therapeutic interest but very few TFs have been successfully drugged. TF D...

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteins by @XianghuaLi2

Are Transcription Factors really 'undruggable'?

www.biorxiv.org/content/10.1...

Many exciting opportunities for a PhD in Life Sciences in CRG, Barcelona. If you are interested in Genomics of Diabetes check out the offer for a fully funded fellowship in our lab - we will consider candidates with experimental or computational backgrounds.

Please spread the word!

The Gaza Famine is the world’s famine. A preventable, predictable famine.

Enough. Ceasefire. Open all crossings, north and south. Let us get food in, unimpeded and at massive scale.

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human genetic evidence demonstrate tha...

A HNF1A-A1CF transcription-splicing axis is suppressed in β cells from #T2D individuals, while genetic variants reducing pancreatic islet A1CF are associated with increased glycemia and T2D susceptibility www.cell.com/cell-metabol...

HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes Bernardo et al. uncover a transcription-splicing regulatory axis driven by HNF1A and A1CF in pancreatic β cells. Targeted perturbations, single-cell studies, and human genetic evidence demonstrate tha...

An HNF1A-A1CF transcription splicing axis regulates insulin secretion, and breaks down in T2D.

Amazing work led by Edgar Bernardo + Matias de Vas + major contributions from Diego Balboa, Silvia Bonas, Mirabai Cuenca, Fanny Mollandin, Merce Planas, Miquel Torrent, MA Maestro and many others

Single-cell ultra-high-throughput multiplexed chromatin and RNA profiling reveals gene regulatory dynamics - Nature Methods This work presents SUM-seq, an ultra-high-throughput method for co-profiling chromatin accessibility and gene expression in single nuclei across multiplexed samples, advancing the study of gene regula...

SUM-seq out @natmethods.nature.com !


🚀 Ultra-high-throughput Multiplexed snATAC+RNA

Used to:
⏳ link temporal macrophage GRNs to immune disease genetics
🩸 map T cell regulatory landscapes
🧬✂️ dissect TF function in hiPSC differentiation via CRISPRi/a screens
doi.org/10.1038/s41592-025-02700-8
🧵

Plot of life expectancy after Type 1 diabetes diagnosis, 1850-2025. After the discovery of insulin in 1921, life expectancies go gradually from zero to seventy years.

These are VERY rough estimates, but here's life expectancy after diagnosis of type-I diabetes over the past 150 years.

It was Banting and Best's discovery of how to isolate insulin in 1921 — not some fucking cooking class — that gave people including my daughter a new lease on life.

Congratulations for this study in @Dev_journal, no small feat in Argentina's anti-Science climate

Want to improve your protein or genomic language model’s performance at zero-shot variant effect prediction? We propose a simple adjustment to likelihood-based predicton

📣 Join us @ ALMU!
If you have expertise in SMLM, experience in building bespoke microscope systems -or you're excited to start building- are familiar with Python, and have a passion for optical microscopy, we’d love to hear from you!
👇
recruitment.crg.eu/content/jobs...
Reposts appreciated-Thanks!

Tracing human clones and lineages with DNA methylation. Congratulations for this fascinating breakthrough!

Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling Krell et al. show that mTORC1 in β cells acts as an activity sensor, activated by the same signals that trigger insulin secretion. This activation, in turn, inhibits insulin release via RhoA-dependent...

Happy to share a work from the Helman lab on how beta cells sense and control their insulin secretion by Krell et al. in @CellReports.

Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling: Cell Reports www.cell.com/cell-reports...

Molecular Correlates of Glycine Receptor Activity in Human β Cells

https://www.sciencedirect.com/science/article/pii/S2212877825000638

Just heard from the VP research that my grant with @dgrand.bsky.social, "Promoting Accurate Information on Social Media" was terminated as well

Is the genome just a bag of genes? A new paper in Science now reports that for two thirds of an organisms' genes the position along the chromosome is actually very tightly constrained! Amazing work from my favorite night scientist
Martin Lercher and his team!
www.science.org/doi/10.1126/...

🚨🚨 New pre-print from the lab. led by the amazing @alejotorrescano.bsky.social !

Alejo & Co. elegantly decode the spatial logic of progenitor cell organization in the developing pancreas — from individual cells to structured cellular communities 🔬🔬🧫🧪
Check-it out ⤵️

Hablan los científicos que quieren emigrar a España por Trump: “Tengo miedo al fascismo” Centros punteros de Barcelona y Madrid reciben decenas de solicitudes de investigadores en Estados Unidos

@elpais.com Many established US scientists are taking a bold decision to move to Europe. EU is devoting funding to this but should be more ambitious elpais.com/ciencia/2025...

Inferring gene regulatory networks from single-cell multiome data using atlas-scale external data - Nature Biotechnology Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data.

Accuracy of gene regulatory network inference is increased by combining multiome single-cell and atlas-scale bulk data go.nature.com/43YySqO
rdcu.be/ebBio

PhD Opportunity in Bioinformatics – Fully Funded for UK Home Fee Students at University of Birmingham on FindAPhD.com PhD Project - PhD Opportunity in Bioinformatics – Fully Funded for UK Home Fee Students at University of Birmingham, listed on FindAPhD.com

We are looking for a keen bioinformatician for a fully funded PhD position!
Drop me an email with your CV!

www.findaphd.com/phds/project...

*last day* to register and submit your work in topics relevant to liver and islets in metabolic disease, including…
- organoid models, regeneration, and synthetic biology
- disease mechanisms and therapies
- genome regulation
- ….others

Join the exciting EMBO Workshop on Liver and Pancreas in Metabolic Disease, which brings together top-tier speakers in an outstanding seaside venue in April 🌊🌅. We’ve designed an interactive and engaging program—register now before it’s too late! ⏳👉 meetings.embo.org/event/25-liv...

Great work by @sviatoslavsidorov.bsky.social !

Still time to apply!

Applications from US welcome – four years can feel longer or shorter depending on where you are 😉

Liver and pancreas in metabolic disease: from pathways to therapies The liver and pancreas arise from a common developmental origin and are controlled by shared gene regulatory programs.These organs are central to two of the most common and devastating metabolic dise…

Application deadline is get closer - make sure you do not miss this exciting EMBO workshop on liver and pancreatic biology and disease 😉

meetings.embo.org/event/25-liv...

If the past two meetings are any indication, this promises to be another great genome regulation workshop

Bridging the gap: How enhancers cooperate to regulate gene expression over large genomic distances By building synthetic regulatory landscapes, Jensen et al.1 and Thomas et al.2 demonstrate in this issue of Molecular Cell that gene expression levels…

Two great articles in Mol Cell about enhancer cooperativity & long-range enhancer activation by @chribue.bsky.social & Wysocka labs:
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...

Dimitra and I had the pleasure to write a Preview:
www.sciencedirect.com/science/arti...

Epigenetics-2025, from mechanisms to disease | Genetics Society Meeting background This international conference will bring together leading experts to foster dynamic discussions on the latest breakthroughs in epigenetics. It will cover mechanisms of epigenetic re...

Join us in Belfast for our #epigenetics meeting and hear from fantastic speakers. Submit an abstract until 26 Jan and register until 23 Feb!

Don't miss this chance to share your research & network with experts in the field.

genetics.org.uk/events/epige...

If you’re interested in doing Postdoc work in Vancouver this is a great opportunity, check out our website and get in touch soon (www.betacell.ca)!

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @benlehner.bsky.social and Toni Beltran is out now in @nature.com. Illustration by @queralttolosa.bsky.social.

Well isn't this cool???

www.medrxiv.org/content/10.1...

Variants in RNU4-2 and RNU6 paralogues could account for up to 1.2% of undiagnosed retinitis pigmentosa cases!

Really neat example of pleiotropy: different RNU4-2 variants underlie neurodevelopmental disorder (ReNU syndrome) and RP.

🤓🧬🖥️🩺❤️