Hiroshi Yano, PhD

🎉 Registration is NOW OPEN! 🎉

We’re excited to welcome you to next year’s International Conference on Innate Lymphoid Cells, where leading experts, innovators, and researchers will come together to share insights, spark collaborations, and shape the future of ILCs and beyond.

#ILC6

(1/3)

BIG NEWS!
The Innate Lymphoid Cell (ILC) 6 Meeting (ILC6) will take place on June 2nd-4th, 2026, in Vancouver!

Keynotes include:
Andrew McKenzie, Kazuyo Moro.

ilc6vancouver.com

#ILC6 #ILC6Vancouver #2026ILC6

(1/3)

“You can’t discover what you don’t study.” @jennifergarrison.bsky.social highlights the need for more focus on women’s health at the Merkin Symposium at Caltech. Hard for anti-diversity folks to argue against addressing health issues that impact half the population…

IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer - Nature IL-33 induces tertiary lymphoid structures.

#ILC2 as an inducer of tertiary lymphoid structures (#TLS) in cancer!

Beautiful study by Balachandran group at MSK.

I'm so happy to have been able to contribute to this exciting story!

www.nature.com/articles/s41...

x.com/thevinodlab/...

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.

Happy to share here: www.nature.com/articles/s41...

Another inhibitory receptor regulating ILC2s.

VISTA, upregulated upon activation, negatively regulates ILC2 proliferation and effector functions through AKT-FOXO1 axis both in mice and humans.

VISTA-AKT-FOXO1 axis suppresses OXPHOS and FAO in ILC2s.

www.jci.org/articles/vie...

A feeding-induced myokine modulates glucose homeostasis - Nature Metabolism The authors identify feimin as a feeding-induced myokine that regulates glucose homeostasis via the MERTK–AKT signalling axis in mice and humans.

🤩 Feimin, a new cytokine encoded by a gene with a previously unknown function, was identified as a synergistic regulator of blood glucose dynamics in concert with insulin.

Insulin = Potent but short action
Feimin = Modest but long-lasting

Interesting

www.nature.com/articles/s42...

😂

Hot off the press 🔥
Very proud of this collaboration! 💫
@Harvard
@JohnsHopkins
@UChicago
@UniHeidelberg

Interested in immunotherapy-induced toxicity? 🤓
This is a must-read 🤩
#immunology #science #cancer #research
@nct-heidelberg.bsky.social @dkfz.bsky.social

www.cell.com/trends/immun...

Nitrogen-fixing organelle in a marine alga Symbiotic interactions were key to the evolution of chloroplast and mitochondria organelles, which mediate carbon and energy metabolism in eukaryotes. Biological nitrogen fixation, the reduction of ab...

Wow…🤯 Nitrogen-fixing organelle “nitroplast”!

We may be witnessing an active evolutionary process of organelle acquisition endosymbiosis in an eukaryote marine alga, like what is considered to be the process that led to mitochondria and chloroplast.

www.science.org/doi/10.1126/...

Some sex-dependent and -independent manner. (i.e. obese women were more likely to have better insulin sensitivity; obese men tend to have more pro-inflammatory macrophages in the adipose tissue, etc)

Unveiling adipose populations linked to metabolic health in obesity Metabolic disease risk in individuals with obesity is variable and influenced by so-far-unknown factors. Reinisch and Ghosh et al. uncovered distinct cell populations and transcriptional programs in adipose tissue that are strongly linked to metabolic disease. The findings suggest that visceral adipose tissue plasticity is key to maintaining metabolic health despite excess adiposity.

Merry festive time🍗🎄

Speaking of festivity and since we’re all thinking about same ole new year resolutions, this study might be a good read to learn about what differentiates metabolically “healthy” vs “unhealthy” obese individuals.

www.cell.com/cell-metabol...

Aside from serotonin receptors, I believe psychedelics bind to TrkB for their antidepressant effect.

Serotonin receptors and TrkB are both expressed on gut-innervating neurons.

I wonder which signaling pathway is involved in the intestinal complications with psychedelics.

Psilocybin desynchronizes the human brain - Nature Healthy adults were tracked before, during and after high doses of psilocybin and methylphenidate to assess how psychedelics can change human brain networks, and psilocybin was found to massively disr...

🤯
Human study demonstrating long-lasting desynchronization and potential mechanism of neuroplasticity induced by psychedelic Psilocybin.

www.nature.com/articles/s41...

Different effects of fatty acid oxidation on hematopoietic stem cells based on age and diet Morrison and colleagues show long-chain fatty acid oxidation has context-dependent effects on hematopoietic stem cells (HSCs). It is dispensable for HSC function in young mice. It becomes necessary for normal HSC function and hematopoiesis in older mice. A high-fat diet increases fatty acid oxidation, and this impairs HSC function.

Long-chain fatty acid oxidation (FAO) is dispensable for hematopoietic stem cells in young mice, while crucial for HSCs in old mice. But then too much FAO is detrimental for HSCs.

Fatty diet makes us unhealthy to the core...literally, our bone marrow…

www.cell.com/cell-stem-ce...

Ever wondered how gut microbes control immune responses at extra-intestinal locations?
Here #theonlylabever reports how a gut protozoan commensal shapes pulmonary immunity to exacerbate asthma and limit the dissemination of mycobacteria.
@cellpress.bsky.social ⬇️(1/x)
www.cell.com/cell/fulltex...

‪
When I pitched a cover featuring #helminths illustrated with #Jugendstil / #ArtNouveau styling to @science.org's amazing Visuals team, never in my wildest dreams did I imagine the finished product would be so exquisite! Scientific illustrator Ashley Mastin really hit it out of the park!

🍄‍🟫 Shiitake mushroom is delicious and good for health. 🍄‍🟫

Tissue-specific ILC progenitors governing distribution, developmental kinetics, and gene expression exist in human fetal development, including CD34+RORγt+Eomes- & CD34+RORγt+Eomes+ progenitors in fetal intestine
doi.org/10.1002/eji....
@eurjimmunol.bsky.social @jakmic.bsky.social

And here is my condensed guide on how to science: top 5 Rules

Rare sighting of wild G-protein in Virginia

I’m proud to join more than 30 colleagues today in sharing our analysis of potential risks from “mirror life”. We summarize our findings in a @science.org article, and in greater detail in a 300pg technical report:

Article: www.science.org/doi/10.1126/...
Report: purl.stanford.edu/cv716pj4036

Nutrient-driven histone code determines exhausted CD8+ T cell fates ACLY-deficient CAR T cells targeting the tumor-associated antigen disialoganglioside GD2 (GD2 CAR T cells) also resisted acquiring TEX-like properties, exhibiting reduced CD39 expression when co-cultu...

The fate of T cells, such as seen in exhausted T cells, is tied to nutrients. This introduces the potential of therapies directed at keeping T cell identity and function intact. (And the infamous Krebs cycle makes a comeback to my brain)

www.science.org/doi/10.1126/...

🤯😍

🔥 Microbial colonisation in early life shapes mast cell NGF production and nociceptor sensitivity later in life. Beautiful new #MucosalImmunology study from the Altier lab out online #OpenAccess: www.mucosalimmunology.org/article/S193...

PYROPTOSIS is a type of programmed cell death characterized by inflammatory cell lysis when gasdermin forms pores in the cell membrane

A gut fungus protects mice against parasitic worms but increases allergies
www.nature.com/articles/d41...
www.nature.com/articles/s41...

Wouldn't have guessed that a PCSK9 blocker (used for LDL cholesterol lowering) might someday be indicated to prevent breast cancer in individuals with a common genomic variant
www.cell.com/cell/fulltex...

Vagal stimulation ameliorates murine colitis by regulating SUMOylation Vagal stimulation or inhibition of SUMOylation with TAK-981 ameliorates colitis in mouse models.

'These results reveal a pathway of vagal neuromodulation that reprograms endogenous stress-adaptive responses through inhibition of SUMOylation and suggest SUMOylation as a therapeutic target for IBD.'
#Immunology #Neuroimmunology
www.science.org/doi/10.1126/...

This Perspective from Nov '24 by Miranda Green and Jane Foster puts the work from @annamolofskylab.bsky.social & @arimolofskylab.bsky.social & colleagues @science.org in the bigger picture of our growing understanding of meningeal immunity.

https://buff.ly/3OLThsq

#Neuroimmunology