Sudarshan Krishnamurthy

Racial and Ethnic Diversity in Clinical Studies Reported to ClinicalTrials.gov, 2009-2024 Importance: A lack of transparent reporting of race and ethnicity in clinical research limits the ability to identify health inequities and evaluate to what extent clinical research includes diverse p...

Our new pre-print presents the reporting, and racial and ethnic diversity of 58,000+ studies in clinicaltrials.gov, the largest global clinical study registry. Reporting of race and ethnicity to the registry began in 2009, and we analyzed data through 2024 #MedSky

www.medrxiv.org/content/10.1...

Starting residency without money for rent or furniture or groceries until
I get my first paycheck mid July. I’m a physician and surgical resident who beat cancer. Please share and donate

If you would like to donate to an incoming general surgery resident who lost his father after his first year of medical school, who also beat cancer, has food insecurity, & graduated without familial support. All contributions are for a security deposit & rent until I get my first paycheck mid July.

I’m going to make individual posts for the Palestinian accounts I’m boosting today so they don’t get lost in a thread but if you are looking for them all in one place I’ll link them here 🔽

Donate to Help Dr. Brisbon with Housing & Food for Surgical Residency, organized by Jonathan Brisbon My name is Dr. Jonathan Lee Brisbon, and I am humbly asking f… Jonathan Brisbon needs your support for Help Dr. Brisbon with Housing & Food for Surgical Residency

I fought cancer. I lost my dad. I became a doctor with no family support. Now I’m weeks away from residency with no housing, no groceries, and no paycheck until mid-July. I’ve come too far to fall now.
Please help.
📲 Venmo: @JBrisbon1181
🙏 gofund.me/850fc46c

#medsky #urosky #mdsky #orthosky

This is so dystopian… 😭😭 I’m so sorry this happened! Truly, what does qualifying for the paramedics even mean?!

Incidence and prevalence of dementia among US Medicare beneficiaries, 2015-21: population based study Objective To determine the incidence and prevalence of dementia in a nationally representative cohort of US Medicare beneficiaries, stratified by important subgroups. Design Population based study. ...

Proud to share my latest paper in @bmj.com www.bmj.com/content/389/.... Takeaways: Dementia incidence ⬇️, prevalence ⬆️, and dementia is unequally distributed. In an opinion article, I argue we need to redouble our efforts to manage multimorbidity across the life course: www.bmj.com/content/389/...

Public health for the people

I had to look back at our initial analytic plans and proposals that we drafted, and it was in August 2022 - it caught me off guard too! 😂

Absolutely - this project wouldn't have happened without help from @dusetzinas.bsky.social and Shelley (who isn't on Bluesky yet)! Can't thank them both enough!😊

Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer This cohort study examines racial and ethnic disparities in the receipt of ERBB2 (formerly HER2 or HER2/neu)–targeted therapies and changes in receipt over time among Medicare beneficiaries with ERBB2...

If you’ve made it this far and would like to learn more, go give it a read for yourself here: jamanetwork.com/journals/jam...

(7/7)

This image is a visual abstract for a paper titled ‘Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer, 2010-2020”. This was a Retrospective Cohort study using a SEER-Medicare Linked Dataset. The sample comprised 12,765 beneficiaries with ERBB2-positive breast cancer, and included those diagnosed from January 2010 to December 2020. The primary outcome of the study was receipt of ERBB2-targeted therapy in 12 months after diagnosis. The primary findings showed a) an increase in overall receipt of ERBB2-targeted therapies from 41.3% to 64.3% over time, and that b) Black & Hispanic patients had a lower likelihood of receipt than White patients in 2010-11, with no differences by 2018-19. The findings suggest a narrowing of racial and ethnic disparities in receipt of therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future work is needed to understand the practices that resulted in the narrowing of disparities to develop implementation strategies and improve pharmacoequity in breast cancer care.

I truly cannot thank this entire team enough for their help in getting this out! (@dusetzinas.bsky.social)

And a special thanks to my mentor, sponsor, and friend in this work, @uressien.bsky.social, for giving me the opportunity to lead this project after we first discussed it back in 2022!

(6/x)

Our biggest takeaway from these findings is that we must understand the practices that contributed to the narrowing of these disparities, so we may develop more implementation strategies towards improving equitable cancer care! 🎯

(5/x)

This figure, from the study being discussed, has a line graph of the percentages of beneficiaries receiving treatment by race and ethnicity between 2010 and 2019 in panel A. Below that, in panel B, is a forest plot of the likelihood of treatment by race and ethnicity from 2010 to 2019 from up to down. Both figure panels show a narrowing of disparities, with Black and Hispanic beneficiaries starting off at lower rates of receipt of ERBB2/HER2-targeted therapies in 2010-11, and these disparities not being observed in 2018-19.

Our main finding was a narrowing of racial and ethnic disparities from 2010 to 2019! 📉

In other words, although Black and Hispanic beneficiaries had lower rates of receipt of ERBB2/HER2-targeted therapies than white beneficiaries in 2010, this disparity was no longer seen in 2019.

(4/x)

This image is a visual abstract for a paper titled ‘Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer, 2010-2020”. This was a Retrospective Cohort study using a SEER-Medicare Linked Dataset. The sample comprised 12,765 beneficiaries with ERBB2-positive breast cancer, and included those diagnosed from January 2010 to December 2020. The primary outcome of the study was receipt of ERBB2-targeted therapy in 12 months after diagnosis. The primary findings showed a) an increase in overall receipt of ERBB2-targeted therapies from 41.3% to 64.3% over time, and that b) Black & Hispanic patients had a lower likelihood of receipt than White patients in 2010-11, with no differences by 2018-19. The findings suggest a narrowing of racial and ethnic disparities in receipt of therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future work is needed to understand the practices that resulted in the narrowing of disparities to develop implementation strategies and improve pharmacoequity in breast cancer care.

To help answer this question, we designed a retrospective cohort study using the SEER–Medicare linked dataset, where the primary outcome was receipt of ERBB2/HER2-targeted therapies in the 12 months after diagnosis, by race and ethnicity.

So, what did we find? ⁉️

(3/x)

Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer This cohort study examines racial and ethnic disparities in the receipt of ERBB2 (formerly HER2 or HER2/neu)–targeted therapies and changes in receipt over time among Medicare beneficiaries with ERBB2...

The main question we asked for this study: Among Medicare beneficiaries diagnosed with ERBB2/HER2–positive breast cancer from 2010-19, are racial/ethnic disparities associated with receipt of ERBB2-targeted therapies, and do these trends change over time? 🤔

🔗: jamanetwork.com/journals/jam...

(2/x)

This image is a visual abstract for a paper titled ‘Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer, 2010-2020”. This was a Retrospective Cohort study using a SEER-Medicare Linked Dataset. The sample comprised 12,765 beneficiaries with ERBB2-positive breast cancer, and included those diagnosed from January 2010 to December 2020. The primary outcome of the study was receipt of ERBB2-targeted therapy in 12 months after diagnosis. The primary findings showed a) an increase in overall receipt of ERBB2-targeted therapies from 41.3% to 64.3% over time, and that b) Black & Hispanic patients had a lower likelihood of receipt than White patients in 2010-11, with no differences by 2018-19. The findings suggest a narrowing of racial and ethnic disparities in receipt of therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future work is needed to understand the practices that resulted in the narrowing of disparities to develop implementation strategies and improve pharmacoequity in breast cancer care.

Sharing a short thread here on our recent publication from earlier this month. This project was an incredible team effort, and truly would not have been possible without every co-author on this all-⭐ team!

Go give it a read here if interested: jamanetwork.com/journals/jam...

A short 🧵:

(1/x)

In this moment, we have an unraveling of biomedical research infrastructure that not only is impacting my own training and research ability, but the future of scientific research. Many of the conversations I've had recently are about pivoting research focus. If I could go back into the future to newly admitted Ph.D. student Michael Green, the most straight forward advice would be to pursue something "non-controversial' so he could position himself for a career to pursue science that the current administration deems "non-controversial'. Avoiding controversy is not why I decided to pursue a Ph.D. in Population Health Sciences focusing on how people are socially treated in health systems. The definition of controversy is also constantly changing, so if avoiding controversy is your guiding framework, your target will be very unstable. I am pursuing this path because I have lived experience where my family members suffered because they feel like they were mistreated and/or unwelcome in healthcare spaces. In this moment, their experiences and trust in health systems are even more fractured than before. Simply pivoting from that work would not help them, so I cannot pivot from the greater mission, given that mission is core to my identity. Science is centered on controversy, we ask questions, run experiments, and make claims based on those experiments. Despite the pivot in how we support (or choose not to support) healthcare research, since I believe the new chaos will not work, we still need people in place to propose new solutions. I am concerned about people who hap-hazardously pivot from their alleged principles. At the same time I understand that the compensation you get in academia is well under corresponding positions in industry or another field. If the mission driven nature of academia is lost, and your ability to choose what you pursue based on your principles is lost, weathering the storm is a lot easier in places where you will make far more money or have less …

Turned 26 today and recently finished my 4th year of my PhD program, so I wrote a new blog where I did some reflecting on the moment we are in.

Compared to when I applied to grad school in 2020, this is nowhere near what I would’ve predicted. Read here:

open.substack.com/pub/notbeing...

Donate to my fundraiser if you’d like to help an exhausted girl out <3 meanwhile I’m going to nap and cry ok ty bai

This sounds incredible - thanks for leading this! I couldn’t make it to SGIM this year, but would love to use any workshop resources that you may be able to share! ☺️

India fires missile barrage into Pakistan as war fears surge Indian army launches ‘Operation Sindoor’, hitting nine sites in Pakistan and Pakistan-administered Kashmir.

If folks aren’t following this yet, you can keep an eye on this link for updates. The situation between India and Pakistan is escalating rapidly at the moment…

www.aljazeera.com/news/liveblo...

Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer This cohort study examines racial and ethnic disparities in the receipt of ERBB2 (formerly HER2 or HER2/neu)–targeted therapies and changes in receipt over time among Medicare beneficiaries with ERBB2...

In the meantime, if you’d like to give it a read, here’s the link to the article!

jamanetwork.com/journals/jam...

#Pharmacoequity

This image is a visual abstract for a paper titled ‘Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer, 2010-2020”. This was a Retrospective Cohort study using a SEER-Medicare Linked Dataset. The sample comprised 12,765 beneficiaries with ERBB2-positive breast cancer, and included those diagnosed from January 2010 to December 2020. The primary outcome of the study was receipt of ERBB2-targeted therapy in 12 months after diagnosis. The primary findings showed a) an increase in overall receipt of ERBB2-targeted therapies from 41.3% to 64.3% over time, and that b) Black & Hispanic patients had a lower likelihood of receipt than White patients in 2010-11, with no differences by 2018-19. The findings suggest a narrowing of racial and ethnic disparities in receipt of therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future work is needed to understand the practices that resulted in the narrowing of disparities to develop implementation strategies and improve pharmacoequity in breast cancer care.

📋‼️Honored to share this newly published article that I helped lead!

Cannot thank @uressien.bsky.social enough - he has served as a friend, mentor, and sponsor throughout! And the whole study team who this wouldn’t have happened without!🙏🏽

Will post a longer thread on the findings soon - stay tuned!

‼️ NEW Paper.

Led by @sudkrishnamurthy.bsky.social we found wide disparities in receipt of ERBB2-targeted 💊 for Medicare enrollees w. breast cancer, disparities that did narrow by 2019.

We need more research to identify strategies to improve cancer #Pharmacoequity.

jamanetwork.com/journals/jam...

Too many people conflate ‘South Asia’=India, forgetting there are 7 countries that make up South Asia. India is in conflict with almost all of them because of its bullying, internal interference, regional hegemony. Many upper-caste Indian-Americans support far-right politics of BJP/RSS & MAGA

Dissertation defense flyer with a white and cream background. The left hand side has a picture of the Wake Forest School of Medicine, a headshot of Sud smiling in a checked Blue shirt, and a logo of the Wake Forest Graduate School of Arts and Sciences from top to bottom. The right hand side has a block of text that reads as follows: You are invited to the Final Dissertation Defense of Sudarshan Krishnamurthy Molecular Medicine and Translational Science Graduate Program for the degree of DOCTOR OF PHILOSOPHY (Ph.D) "Investigating the Relationships of Place-based Social Determinants of Health and Structural Racism with Measures of Alzheimer's Disease and Related Dementias" Friday, March 28th, 2025, 9:00am Please DM or Email sukrishn@wakehealth.edu for Location and/or Virtual Meeting Link Information.

We’re finally there, y’all! I’ll be defending my final PhD dissertation next Friday, March 28th! Excited to see you on the other side of it!

Think this is a great time to lift up the legacy and work of W.E.B DuBois and Ida B. Wells in using journalism, ethnography, and data to highlight the propaganda of white supremacy. They were able to pierce through official lies with meticulous work and compelling methods of communication.

This is what’s happening as the “you know who the real problem is?” discourse is churning.

Legacies of ableism and the pursuit of disability justice in medicine I was diagnosed with chronic inflammatory demyelinating polyneuropathy at the age of 16 years as I began training in Indian classical dance. This rare neurological condition resulted in partial paraly...

"The core of disability justice lies the belief that no one is left
behind. This begins with transforming the global mindset to
embrace us who are disabled as vital members of society"

@ananyatb.bsky.social in the @thelancet.bsky.social

www.thelancet.com/journals/lan....

A grassroots movement is calling on all Americans to abstain from shopping with major retailers tomorrow, February 28, as part of an “economic blackout.”

I encourage you to join. https://robertreich.substack.com/p/boycott