Sudarshan Krishnamurthy, PhD

Sudarshan Krishnamurthy, PhD

@sudkrishnamurthy.bsky.social

MD/PhD Student | Abolitionist Public Health & Health Justice | Research - SDoH, Structural Racism, and ADRD | Views my own. https://www.linktr.ee/sudkrishnamurthy

1,156 Followers 188 Following 55 Posts Joined Sep 2023
3 weeks ago
This is a flyer for the Rest & ME/CFS research study, IRB number 26-6. It says "participate in a survey about rest, energy, and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". In the upper right corner it says Questions? Email Study Co-PI Victoria: empwrtc@protonmail.com
Below the header is interwoven circles, one is black with text that says Fully Virtual, low- energy version included. The circle behind is an image of white silk wrinkled. Next to it text says To participate you must be: Over the age of 18 AND EITHER Have ME/CFS (self or professionally diagnosed) or be A medical/healthcare provider who has
worked with at least one person with ME/CFS, currently practicing or conducting research. Below this it says learn more at www.restandmecfs.com. There are two icons on the bottom left corner. One says ETC and above it are six icon-stick
figure people holding hands in a circle. Next to it is Cal Poly Pomona's logo, a diamond with an orangey yellow background and palm trees and a building inside.
The Cal Poly Pomona Institutional Review Board has reviewed and approved for conduct
this research involving human subjects under protocol IRB 26-6

Hi everyone, I wanted to share a research study I just launched on rest, energy, & ME/CFS, open to people with ME/CFS & medical or healthcare providers who are currently practicing or conducting research & have had at least 1 patient or participant with ME/CFS. Visit restandmecfs.com for more.

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2 months ago

Go check our new study out -- this work was the 2nd of my dissertation chapters! 😊

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2 months ago
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Interested in the relationship between place-based social determinants of health (SDoH) and Alzheimer's disease and related dementias biomarkers?

Check out this new research published in #BSEA!

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

#AlzSky

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3 months ago
Where You Live May Affect Your Brain Health, New Study Finds Where You Live May Affect Your Brain Health, New Study Finds

And if you’d rather take a look at our institutional press release, you can check that out here! 🗞️
newsroom.wakehealth.edu/news-release...

If you made it this far, thank you for reading! 😊

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3 months ago
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Associations of place‐based social determinants of health with biomarkers of Alzheimer's disease and related dementias INTRODUCTION Relationships between place-based social determinants of health (SDoH) and Alzheimer's disease and related dementias biomarkers are emerging. METHODS Linear regressions examined assoc...

If you’re interested in diving deeper into the findings of this study, go give it a read here! 🔎📝

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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3 months ago
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REVEALED: US Counties where you're most likely to develop dementia A new study links living in socially and economically disadvantaged neighborhoods to a drastically increased risk of dementia.

In the study, we call for an increased investment in grassroots initiatives and policy efforts to combat the neighborhood-level SDoH burden to remedy the disparities in ADRD outcomes! 📣

See here for some coverage of our work: www.dailymail.co.uk/health/artic...
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3 months ago
This image is a visual or graphical abstract of the study titled 'Associations of place-based social determinants of health with biomarkers of Alzheimer's disease and related dementias'. The image describes this to be a retrospective cohort study in the Wake Forest Alzheimer's Disease Research Center, including 679 participants from the Healthy Brain Study, running from 2016 to 2024. The primary outcomes of the study included neuroimaging and plasma biomarkers of Alzheimer's Disease and related Dementias. Findings in the study highlighted that the burden of place-based social determinants of health (SDoH) was higher among Black participants. Additionally, among Black participants, higher levels of neighborhood disadvantage, social vulnerability, and environmental injustice is related to worse biomarker outcomes. The discussion of the study highlighted that this higher SDoH burden was associated with changes in dementia-related neuroimaging biomarkers, particularly related to cerebrovascular health and brain structure, among Black participants. It is important to invest in grassroots initiatives and policy efforts to combat SDoH at a neighborhood-level in an effort to improve ADRD outcomes.

Specifically, what we found suggested that the higher SDoH burden was associated with poorer cerebrovascular health and brain structure among Black participants in the study. 🧠‼️

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3 months ago

So, what did we find?🔎

First, we found that Black participants in the study faced a higher burden of place-based SDoH. 🗺️

Second, we found that these higher burdens of SDoH were associated with worse biomarker outcomes among Black participants.‼️

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3 months ago
This image is a visual or graphical abstract of the study titled 'Associations of place-based social determinants of health with biomarkers of Alzheimer's disease and related dementias'. The image describes this to be a retrospective cohort study in the Wake Forest Alzheimer's Disease Research Center, including 679 participants from the Healthy Brain Study, running from 2016 to 2024. The primary outcomes of the study included neuroimaging and plasma biomarkers of Alzheimer's Disease and related Dementias. Findings in the study highlighted that the burden of place-based social determinants of health (SDoH) was higher among Black participants. Additionally, among Black participants, higher levels of neighborhood disadvantage, social vulnerability, and environmental injustice is related to worse biomarker outcomes. The discussion of the study highlighted that this higher SDoH burden was associated with changes in dementia-related neuroimaging biomarkers, particularly related to cerebrovascular health and brain structure, among Black participants. It is important to invest in grassroots initiatives and policy efforts to combat SDoH at a neighborhood-level in an effort to improve ADRD outcomes.

This study was conducted within the Wake Forest Alzheimer’s Disease Research Center, and included 679 older adults across the cognitive spectrum! 🧓🏼👵🏼🧓🏾👵🏾

The primary research question in the study was to examine the relationships of place-based SDoH with biomarkers of dementia.❓

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3 months ago
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Associations of place‐based social determinants of health with biomarkers of Alzheimer's disease and related dementias INTRODUCTION Relationships between place-based social determinants of health (SDoH) and Alzheimer's disease and related dementias biomarkers are emerging. METHODS Linear regressions examined assoc...

I’m excited to share the 2nd study from my dissertation work titled “Associations of Place-based Social Determinants of Health with Biomarkers of Alzheimer’s Disease and Related Dementias”! ✨

You can read it here: alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

A short 🧵 here!

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4 months ago
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According to NEW STUDY from Timothy Hughes, et al. @wakeforestmed.bsky.social, "the conditions where you live may influence your brain health & risk for #Dementia". Learn More @alzdemjournals.bsky.social @alzassociation.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

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5 months ago
Sud with his family — Sud’s dad is on his left, with Sud’s uncle to the extreme left. Sud’s aunt is on his right, with Sud’s uncle to her right. Sud’s partner, Bailey, is on the extreme right — far-left of the image. Sud at one of their favorite breweries, Lesser-Known Beer Company, in front of barrels where beers are being aged, wearing a sash that reads “Ph.inisheD” and a decorative gold “PHD” sign hanging above!

All of this will also eventually culminate in my life’s work to intervene on those social and structural determinants to improve health for all!

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5 months ago
A picture of cinnabon delights bought for Sud by their partner, Bailey, with little celebratory PhD signs on toothpicks sticking out from it! Sud along with their dissertation committee members, who could make it in person to the defense. Two of Sud’s committee members could only join virtually — Dr. Sarah Forrester and Dr. Chris Whitlow.

I’m excited to see the work from my dissertation get out there over the coming months, and to further build upon this work to illustrate the influence of the social and structural determinants of health on dementia.

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5 months ago
Front page of Sud’s dissertation titled ‘Investigating the Relationships of Place-based Social Determinants of Health and Structural Racism with Measures of Alzheimer’s Disease and Related Dementias”. 

The rest of the text on the title page reads as follows:
BY
SUDARSHAN KRISHNAMURTHY
A Dissertation Submitted to the Graduate Faculty of
WAKE FOREST UNIVERSITY GRADUATE SCHOOL OF ARTS AND SCIENCES in Partial Fulfilment of the Requirements for the Degree of
DOCTOR OF PHILOSOPHY
Molecular Medicine and Translational Science
May 2025
Winston-Salem, North Carolina
Approved By:
Timothy M. Hughes, PhD, MPH, Advisor
James R. Bateman, MD, MPH, Chair
Sarah N. Forrester, PhD, MS
Da Ma, PhD
Ellen Quillen, PhD
Christopher Whitlow, MD, PhD Sud standing in a dark blue suit and blue shirt grinning as he wears a sash that reads “Ph.inisheD”.

Not a typical post (🧵) on here, but just over 6 months ago, I successfully defended my dissertation alongside friends, family, my committee, and many loved ones. It was a wonderful day, and I have so many people to thank for their support over the past 3 years and more!

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7 months ago
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Racial and Ethnic Diversity in Clinical Studies Reported to ClinicalTrials.gov, 2009-2024 Importance: A lack of transparent reporting of race and ethnicity in clinical research limits the ability to identify health inequities and evaluate to what extent clinical research includes diverse p...

Our new pre-print presents the reporting, and racial and ethnic diversity of 58,000+ studies in clinicaltrials.gov, the largest global clinical study registry. Reporting of race and ethnicity to the registry began in 2009, and we analyzed data through 2024 #MedSky

www.medrxiv.org/content/10.1...

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8 months ago

Starting residency without money for rent or furniture or groceries until
I get my first paycheck mid July. I’m a physician and surgical resident who beat cancer. Please share and donate

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9 months ago
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If you would like to donate to an incoming general surgery resident who lost his father after his first year of medical school, who also beat cancer, has food insecurity, & graduated without familial support. All contributions are for a security deposit & rent until I get my first paycheck mid July.

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1 year ago

I’m going to make individual posts for the Palestinian accounts I’m boosting today so they don’t get lost in a thread but if you are looking for them all in one place I’ll link them here 🔽

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9 months ago
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Donate to Help Dr. Brisbon with Housing & Food for Surgical Residency, organized by Jonathan Brisbon My name is Dr. Jonathan Lee Brisbon, and I am humbly asking f… Jonathan Brisbon needs your support for Help Dr. Brisbon with Housing & Food for Surgical Residency

I fought cancer. I lost my dad. I became a doctor with no family support. Now I’m weeks away from residency with no housing, no groceries, and no paycheck until mid-July. I’ve come too far to fall now.
Please help.
📲 Venmo: @JBrisbon1181
🙏 gofund.me/850fc46c

#medsky #urosky #mdsky #orthosky

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9 months ago

This is so dystopian… 😭😭 I’m so sorry this happened! Truly, what does qualifying for the paramedics even mean?!

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9 months ago
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Incidence and prevalence of dementia among US Medicare beneficiaries, 2015-21: population based study Objective To determine the incidence and prevalence of dementia in a nationally representative cohort of US Medicare beneficiaries, stratified by important subgroups. Design Population based study. ...

Proud to share my latest paper in @bmj.com www.bmj.com/content/389/.... Takeaways: Dementia incidence ⬇️, prevalence ⬆️, and dementia is unequally distributed. In an opinion article, I argue we need to redouble our efforts to manage multimorbidity across the life course: www.bmj.com/content/389/...

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9 months ago

Public health for the people

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9 months ago

I had to look back at our initial analytic plans and proposals that we drafted, and it was in August 2022 - it caught me off guard too! 😂

Absolutely - this project wouldn't have happened without help from @dusetzinas.bsky.social and Shelley (who isn't on Bluesky yet)! Can't thank them both enough!😊

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9 months ago
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Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer This cohort study examines racial and ethnic disparities in the receipt of ERBB2 (formerly HER2 or HER2/neu)–targeted therapies and changes in receipt over time among Medicare beneficiaries with ERBB2...

If you’ve made it this far and would like to learn more, go give it a read for yourself here: jamanetwork.com/journals/jam...

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9 months ago
This image is a visual abstract for a paper titled ‘Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer, 2010-2020”. This was a Retrospective Cohort study using a SEER-Medicare Linked Dataset. The sample comprised 12,765 beneficiaries with ERBB2-positive breast cancer, and included those diagnosed from January 2010 to December 2020. The primary outcome of the study was receipt of ERBB2-targeted therapy in 12 months after diagnosis. The primary findings showed a) an increase in overall receipt of ERBB2-targeted therapies from 41.3% to 64.3% over time, and that b) Black & Hispanic patients had a lower likelihood of receipt than White patients in 2010-11, with no differences by 2018-19. The findings suggest a narrowing of racial and ethnic disparities in receipt of therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future work is needed to understand the practices that resulted in the narrowing of disparities to develop implementation strategies and improve pharmacoequity in breast cancer care.

I truly cannot thank this entire team enough for their help in getting this out! (@dusetzinas.bsky.social)

And a special thanks to my mentor, sponsor, and friend in this work, @uressien.bsky.social, for giving me the opportunity to lead this project after we first discussed it back in 2022!

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9 months ago

Our biggest takeaway from these findings is that we must understand the practices that contributed to the narrowing of these disparities, so we may develop more implementation strategies towards improving equitable cancer care! 🎯

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9 months ago
This figure, from the study being discussed, has a line graph of the percentages of beneficiaries receiving treatment by race and ethnicity between 2010 and 2019 in panel A. Below that, in panel B, is a forest plot of the likelihood of treatment by race and ethnicity from 2010 to 2019 from up to down. Both figure panels show a narrowing of disparities, with Black and Hispanic beneficiaries starting off at lower rates of receipt of ERBB2/HER2-targeted therapies in 2010-11, and these disparities not being observed in 2018-19.

Our main finding was a narrowing of racial and ethnic disparities from 2010 to 2019! 📉

In other words, although Black and Hispanic beneficiaries had lower rates of receipt of ERBB2/HER2-targeted therapies than white beneficiaries in 2010, this disparity was no longer seen in 2019.

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9 months ago
This image is a visual abstract for a paper titled ‘Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer, 2010-2020”. This was a Retrospective Cohort study using a SEER-Medicare Linked Dataset. The sample comprised 12,765 beneficiaries with ERBB2-positive breast cancer, and included those diagnosed from January 2010 to December 2020. The primary outcome of the study was receipt of ERBB2-targeted therapy in 12 months after diagnosis. The primary findings showed a) an increase in overall receipt of ERBB2-targeted therapies from 41.3% to 64.3% over time, and that b) Black & Hispanic patients had a lower likelihood of receipt than White patients in 2010-11, with no differences by 2018-19. The findings suggest a narrowing of racial and ethnic disparities in receipt of therapies over time among older Medicare beneficiaries with ERBB2-positive breast cancer. Future work is needed to understand the practices that resulted in the narrowing of disparities to develop implementation strategies and improve pharmacoequity in breast cancer care.

To help answer this question, we designed a retrospective cohort study using the SEER–Medicare linked dataset, where the primary outcome was receipt of ERBB2/HER2-targeted therapies in the 12 months after diagnosis, by race and ethnicity.

So, what did we find? ⁉️

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9 months ago
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Racial and Ethnic Disparities in Receipt of ERBB2-Targeted Therapy for Breast Cancer This cohort study examines racial and ethnic disparities in the receipt of ERBB2 (formerly HER2 or HER2/neu)–targeted therapies and changes in receipt over time among Medicare beneficiaries with ERBB2...

The main question we asked for this study: Among Medicare beneficiaries diagnosed with ERBB2/HER2–positive breast cancer from 2010-19, are racial/ethnic disparities associated with receipt of ERBB2-targeted therapies, and do these trends change over time? 🤔

🔗: jamanetwork.com/journals/jam...

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