Landon Getz (@landongetz) — Bluesky Profile

1 day ago

New OpenFold3 preview out! (OF3p2)

It closes the gap to AlphaFold3 for most modalities.

Most critically, we're releasing everything, including training sets & configs, making OF3p2 the only current AF3-based model that is functionally trainable & reproducible from scratch🧵1/9

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2 days ago

A tabby cat sleeping on a blue blanket. With his head flipped upside down, his toes are visible at the bottom of the photo.

A tabby cat splayed out in a sunbeam, looking at the camera

Our little (big) guy goes to the cardiologist twice a year for a heart that is too big!

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4 days ago

Marine virologist, astrophysicist earn UBC’s top research prizes UBC recognizes six Science faculty members for research excellence, with two of the university's top prizes awarded to Dr. Curtis Suttle and Dr. Jess McIver.

Two of UBC’s premier research prizes were awarded to UBC Science faculty members today, with Dr. Curtis Suttle (@virosphere.bsky.social) receiving the Jacob Biely award, and Dr. Jess McIver earning UBC’s Charles A. McDowell award.
@killamtrusts.bsky.social

science.ubc.ca/news/2026-03...

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1 week ago

🚨Preprint! Happy to share the research from my PhD “Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism”. We use cryoEM to study the genome ejection of the phage T4, revealing how the tape measure protein regulates the process.
www.biorxiv.org/content/10.6...

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2 weeks ago

Proud to see our work featured in this Spotlight in @cp-trendsmicrobiol.bsky.social by @mvelascogomariz.bsky.social and @jenshoer.bsky.social!
They highlight how phage infection involves surprisingly rich posttranscriptional regulatory networks and sRNA-based regulation.
Thank you for the spotlight!

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2 weeks ago

A 5-hydroxymethylcytosine DNA glycosylase provides defense against T-even bacteriophages https://www.biorxiv.org/content/10.64898/2026.02.25.707755v1

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3 weeks ago

We're happy to share our first Research Spotlight! Dr. Janssen's publication was selected as an Editor's Pick in the Journal of Virology, in which they propose using viruses as gene-delivery tools in mosquitoes. Read the full paper here: tinyurl.com/3efv4vzs

#QueerInSTEM #Microbiology #Virology

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3 weeks ago

Full loaf of artisan Sourdough bread sitting on top of a wire rack. That wire rack is on top of a black stove top.

Picture of my hand holding the sourdough bread cut in half to reveal internal crumbs structure.

Sourdough starter is once again going strong, so we are back to weekend bakes! Glad to see I still got it 😎

Pain de campagne: 10% whole wheat, 80% hydration

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3 weeks ago

Let's celebrate this wonderful achievement by our member, Dr. Joseph Rouse! 🧪 🏳️‍🌈 👨‍🔬

Want to be featured too? Access tinyurl.com/bdch6mkf for more information!

#LGBTQSTEM #Microbiology #EmoryUniversity

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1 month ago

Happy International Day for Women and Girls in Science! @mcmasteriidr.bsky.social @mcmasternexus.bsky.social @mcmasteruniversity.bsky.social

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1 month ago

Looking for a place to chill, vent, or hang out with fun queer microbiologists?

Look no further! Join us at one of our virtual Coffee Hour events and make new friends!

🏳️‍🌈 🦠 ☕️

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1 month ago

BackToBack #PhageSky in @nature.com

A pore-forming antiphage defence is activated by oligomeric phage proteins
-from Maxwell & Norris
www.nature.com/articles/s41...

Bacterial immune activation via supramolecular assembly with phage triggers
-from Laub & Ghanbarpour
www.nature.com/articles/s41...

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1 month ago

Bacterial immune activation via supramolecular assembly with phage triggers - Nature An antiphage defence system has an activation mechanism that relies on the sensing of phage-encoded proteins that enforce geometry crucial to activation and are not typically present in non-infec...

Also published today: an equally cool story from Mike Laub's lab on another oligomeric phage protein, RAZR
www.nature.com/articles/s41...

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1 month ago

A pore-forming antiphage defence is activated by oligomeric phage proteins - Nature Bacteria use diverse defence systems against phages, including a 164-residue prophage-encoded protein, Rip1, which senses conserved phage assembly rings to form membrane pores that block virion matura...

Congratulations Pramal, @paramyxologist.bsky.social, and @themaxwelllab.bsky.social on this incredible story! Glad I got to help, even if it was just a little bit :)
www.nature.com/articles/s41...

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1 month ago

Amazing findings in geometry-based immune activation! Two bacterial defence systems detect phage-encoded ring oligomers, assemble high-order molecular complexes, and trigger abortive infection.

www.nature.com/articles/s41...
www.nature.com/articles/s41...

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1 month ago

Chemical inhibition of a bacterial immune system Bacteriophages are promising alternatives to antibiotics for treating bacterial infections. However, bacteria possess immune systems that neutralize bacteriophages. Zang et al. discover small molecule...

Chemical inhibition of a bacterial immune system: Cell Host & Microbe www.cell.com/cell-host-mi...

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1 month ago

A DNA recognition-mimicry switch governs induction in arbitrium phages Chmielowska et al. reveal how arbitrium phages coordinate host stress and viral communication to control induction. An SOS-regulated antirepressor disables an unusual phage repressor by DNA mimicry, while quorum sensing prevents prophage activation when related lysogens are abundant.

A DNA recognition-mimicry switch governs induction in arbitrium phages: Cell Host & Microbe https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(26)00037-5

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1 month ago

Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases Many bacterial defense systems restrict phage infection by breaking the molecule NAD+ to its constituents, adenosine diphosphate ribose (ADPR) and nicotinamide (Nam). To counter NAD+ depletion-mediated defense, phages evolved NAD+ reconstitution pathway 1 (NARP1), which uses ADPR and Nam to rebuild NAD+. Here we report a bacterial defense system called aRES, involving RES-domain proteins that degrade NAD+ into Nam and ADPR-1″-phosphate (ADPR-1P). This molecule cannot serve as a substrate for NARP1, so that NAD+ depletion by aRES defends against phages even if they encode NARP1. We further discover that some phages evolved an extended NARP1 pathway capable of overcoming aRES defense. In these phages, the NARP1 operon also includes a specialized phosphatase, which dephosphorylates ADPR-1P to form ADPR, a substrate from which NARP1 then reconstitutes NAD+. Other phages encode inhibitors that directly bind aRES proteins and physically block their active sites. Our study describes new layers in the NAD+-centric arms race between bacteria and phages and highlights the centrality of the NAD+ pool in cellular battles between viruses and their hosts. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, ERC-AdG GA 101018520 Israel Science Foundation, MAPATS grant 2720/22 Deutsche Forschungsgemeinschaft, SPP 2330, grant 464312965 Minerva Foundation with funding from the Federal German Ministry for Education and Research research grant from Magnus Konow in honor of his mother Olga Konow Rappaport Ministry of Aliyah and Immigrant Absorption, https://ror.org/05aycsg86 Clore Scholars Program

🧬 Metabolic arms race continues!
We discovered a new NAD⁺-depleting bacterial immune system aRES and phage enzymes that overcome it.
Our preprint is out: www.biorxiv.org/content/10.6...

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1 month ago

Bacterial defense via RES-mediated NAD+ depletion is countered by phage phosphatases Many bacterial defense systems restrict phage infection by breaking the molecule NAD+ to its constituents, adenosine diphosphate ribose (ADPR) and nicotinamide (Nam). To counter NAD+ depletion-mediated defense, phages evolved NAD+ reconstitution pathway 1 (NARP1), which uses ADPR and Nam to rebuild NAD+. Here we report a bacterial defense system called aRES, involving RES-domain proteins that degrade NAD+ into Nam and ADPR-1″-phosphate (ADPR-1P). This molecule cannot serve as a substrate for NARP1, so that NAD+ depletion by aRES defends against phages even if they encode NARP1. We further discover that some phages evolved an extended NARP1 pathway capable of overcoming aRES defense. In these phages, the NARP1 operon also includes a specialized phosphatase, which dephosphorylates ADPR-1P to form ADPR, a substrate from which NARP1 then reconstitutes NAD+. Other phages encode inhibitors that directly bind aRES proteins and physically block their active sites. Our study describes new layers in the NAD+-centric arms race between bacteria and phages and highlights the centrality of the NAD+ pool in cellular battles between viruses and their hosts. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, ERC-AdG GA 101018520 Israel Science Foundation, MAPATS grant 2720/22 Deutsche Forschungsgemeinschaft, SPP 2330, grant 464312965 Minerva Foundation with funding from the Federal German Ministry for Education and Research research grant from Magnus Konow in honor of his mother Olga Konow Rappaport Ministry of Aliyah and Immigrant Absorption, https://ror.org/05aycsg86 Clore Scholars Program

We found a new mode by which bacteria deplete NAD+ to protect from phages. And then we found how phages overcome this defense

Discovered by talented biochemist Dr Ilya Osterman, read the preprint: tinyurl.com/Narp-ap

A thread 🧵

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1 month ago

This amazing woman worked so hard for science and sport in Canada. She set up the Standing Committee on Science and Research, was a powerful voice for science in parliament and after being diagnosed with two cancers continued to advocate for good. Proud to have known the Rt Hon Kirsty Duncan. RIP 💔

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1 month ago

Our latest CRISPR ring nuclease paper focusses on Csx15 - which seems to act as of a sponge as well as a canonical phosphodiesterase. Great work led by @haotianchi.bsky.social

www.biorxiv.org/content/10.6...

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2 months ago

Phold's manuscript is now available @narjournal.bsky.social thanks to @susiegriggo.bsky.social @npbhavya.bsky.social @vijinim.bsky.social @linsalrob.bsky.social @martinsteinegger.bsky.social @milot.bsky.social @eunbelivable.bsky.social & others not on bsky #phagesky academic.oup.com/nar/article/...

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2 months ago

Me, before and after having the flu for the first week of January

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2 months ago

During my postdoc in @therubinlab.bsky.social, @leosong.bsky.social and I aimed to make CRISPR-associated transposons more efficient for editing bacteria.

Couldn’t have done it w/o a CAST of characters at IGI and beyond @innovativegenomics.bsky.social, @cresslab.bsky.social, @doudna-lab.bsky.social

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2 months ago

Vibrio2026: The International Meeting on the Biology of Vibrios Join Vibrio2026: The International Meeting on the Biology of Vibrios, September 13-16, 2026. Learn more on Fourwaves.

Registration is open for September’s Vibrio2026 conference in Berlin! event.fourwaves.com/vibrio2026/p...

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2 months ago

Diverse bacterial pattern recognition receptors sense the conserved phage proteome Recognition of foreign molecules inside cells is critical for immunity in all domains of life. Proteins of the STAND NTPase superfamily, including eukaryotic nucleotide-binding oligomerization domain ...

NLR-like immunity in bacteria

A new study from the Alex Gao lab. The scope of this work is incredible!!!

www.biorxiv.org/content/10.6...

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3 months ago

Xfiles Fan art. Pencil drawing of a scene from 'The Post-Modern Prometheus' an episode from the 5th season of X Files. Mulder and Scully are in a car, Mulder is driving, Scully is looking down at something. I have made it a bit festive and hinted at snow outside the car window.

Driving in the snow // #xfiles
Pencil and chalk pencil on moleskine

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3 months ago

🤦

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3 months ago

Systematic discovery of TIR-based immune signaling systems in bacteria Toll/interleukin-1 receptor (TIR) domains are important for immune signaling across humans, plants and bacteria. These domains were recently found to produce immune signaling molecules in plant immuni...

I’m happy to share our new preprint! We uncovered the full diversity of bacterial TIR-based antiviral immune signaling, massively expanded the known diversity of Thoeris systems, and revealed conservation of TIR-derived immune signals across the tree of life.

www.biorxiv.org/content/10.6...

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3 months ago

Systematic discovery of TIR-based immune signaling systems in bacteria https://www.biorxiv.org/content/10.64898/2025.12.03.692087v1

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