Garvin SUMO Biology Lab

A modular genetic code expansion approach to site-specific lysine acylations A modular strategy combining genetic code expansion with a selective amide bond-forming reaction enables the site-specific installation of lysine acylations on folded proteins. Acylboronates react sel...

🚨 Our new paper is out! 🙌

Bioorthogonal reactions often create bulky, non-native linkages-great for labeling, but not ideal for installing natural PTMs.
We combine GCE with a chemoselective amide-bond forming reaction to install site-specific acylation PTMs.
www.cell.com/chem/fulltex...
1/4

RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Wang et al. show that OXCT1 and HDAC11 regulate RAD51 K285 succinylation, thereby suppressing homologous recombination repair and enhancing chemosensitivity.

Online Now: RAD51 succinylation regulates homologous recombination and contributes to the chemosensitivity in cancer Online now:

The Royal Society's Newton International Fellowships are now open for applications, aimed at non-UK early career scientists who wish to conduct research in the UK. Find out more and apply by 11 March: #RSGrants https://royalsociety.org/grants/newton-international/

The final version of our article on XPF-ERCC1-SLX4 complexes has now been published (the link below still works). I am happy to report that the rendering of our DNA gels has now been corrected. 😉

Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳

Excited to share our new Nature study! 🧬

We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.

Full paper: www.nature.com/articles/s41...

Check out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...

Vincenzo D’Angiolella @vdangioe3lab.bsky.social et al show that the little-studied F-box protein FBXO42 exerts many of its cellular roles by limiting PP4 phosphatase activity to ensure proper DNA damage signaling
link.springer.com/article/10.1...

IFI16 senses and protects stalled replication forks Replication stress is a key driver of DNA damage and genome instability. Here, we report that replication stress induces an inflammatory response in t…

New paper in collaboration with @unterholznerlab.bsky.social @cejkalab.bsky.social IFI16 protects stalled replication forks.

www.sciencedirect.com/science/arti...

The 2025 Policy Impact and Public Engagement Awards winners The Institute is proud to announce the winners of this year

Congratulations to the 2025 Policy Impact and Public Engagement Awards winners! 🎉

Meet them at www.nottingham.ac.uk/policyengage... #WeAreUoN

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS Abstract. Disassembly of the replication machinery (replisome) from chromatin is an active process driven by two ubiquitin ligases Cul2LRR1 and TRAIP, whic

It is finally out 👍😀. Great job of the team (mostly absent from Bsky) and @m-saponaro.bsky.social

CDK-driven phosphorylation of TRAIP is essential for mitotic replisome disassembly and MiDAS url: academic.oup.com/nar/article/...

Ever wondered how TIMELESS/TIPIN can sit at the leading edge of the replication fork regulating its speed, but also bind polymerases and ssDNA/RPA in replication stress? We have an idea how it might work! Check out our new preprint, any feedback is highly appreciated!
www.biorxiv.org/content/10.6...

a cartoon drawing of a clock with a face and arms and legs Alt: a cartoon drawing of a clock with a face and arms and legs

Deadline to apply for MRC fully funded 4-year PhD studentships is approaching on *9 Jan 2026*!
Join world-class researchers across
@unibirmingham.bsky.social ,
@uniofleicester.bsky.social and @uniofnottingham.bsky.social

👉See more.bham.ac.uk/mrc-aim/phd-...

Our latest publication, bringing together advances in our understanding of the complexities in SUMO-DNA-repair signalling. Including 2025 papers from @themorrislab.bsky.social and @leneyms.bsky.social on SUMO4, PIN1-RNF168 and SUMO-E1 . @biochemsoc.bsky.social portlandpress.com/essaysbioche...

Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester on FindAPhD.com PhD Project - Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes at The University of Manchester, listed on FindAPhD.com

I have a PhD position available with start date September 2026 at the University of Manchester.

Proteomics analysis of flow cytometry-based isolated pathogen-containing phagosomes

Due to funding requirements, this position is for UK home students only.

www.findaphd.com/phds/project...

Two more Wellcome Discovery Awards reinforce Leeds as leader in biological research Some of Leeds’ top biological researchers have received two new Wellcome Discovery Awards, confirming the university’s status as a centre of excellence in biological research.

Leeds researchers have secured two major Wellcome Trust Discovery Awards.

The awards bring £3.4 million to support research exploring life at the molecular level and to deepen our understanding of disease.

🔗Full story: bit.ly/4oW3D99

@astburycentre.bsky.social @universityofleeds.bsky.social

Emerging roles of RNA:DNA hybrid regulation by mammalian ribonuclease H2 in replication stress and cancer Summary: Control of RNA:DNA hybrids by RNase H2 helps protect genome stability. Recent insights into RNase H2 molecular functions and alterations in cancer shed new light on mechanisms of human diseas...

Our review article on recent RNase H2 in replciation stress and cancer has been published in @jcellsci.bsky.social! Thank you for the invitation Journal of Cell Science @jcellsci.bsky.social and Company of Biologists @biologists.bsky.social.

journals.biologists.com/jcs/article/...

How DNA secondary structures drive replication fork instability DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…

Our @costerlab.bsky.social review is out!

It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!

www.sciencedirect.com/science/arti...

@adityasethi.bsky.social @billiedelpino.bsky.social

BBS Awards BBS Awards The BBS Kendrew Doctoral Thesis Prize was established in 2019 and will be awarded every two years for an outstanding PhD thesis in biophysics for which the principal work has been carried o...

🎉 Congrats to the faculty's Dr Jonathan Machin who has been awarded the British Biophysical Society's 2026 Kendrew Doctoral Thesis Prize, for his outstanding research on outer membrane proteins.

Read more here: britishbiophysics.org/awards/

A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription - Nature Communications Pathogenic BRCA2 truncating variants in heterozygosis drive distinct cancer-linked mechanisms. Here the authors show that one causes PARPi sensitivity and HR loss via haploinsufficiency, while another...

🚨 Exciting news! Our latest study is out in Nature Communications!
We reveal how specific BRCA2 mutations can hijack transcriptional programs—beyond their role in DNA repair.
🔗 rdcu.be/eT1R9
#CancerResearch #BRCA2 #Genomics

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

You know ubiquitination, you may know ADP-ribosylation... But ubiquitination of ADP-ribose aka MARubylation???

Read our brief spotlight on @michaelnadbio.bsky.social and @jnpruneda.bsky.social 's recent work describing this dual modification here!

New plant-specific DUBs that cleave K63 Chains and reduce endocytosis rates by the Hofmann Lab (Köln)

The second part of our (with @origichals.bsky.social and El Hadji) two-part review on non-covalent SUMO interactions is now published, focussing on SUMO-interacting motifs (SIMs), but discussing also other confirmed or potential SUMO-interacting elements.

Typos in the genome: Defining the molecular mechanism of replication slippage Typos in the genome: Defining the molecular mechanism of replication slippage

📢 Last days to apply! 📢

Fully funded PhD position, starting Oct 2026.

Deadline Nov 16th.

We provide a supportive environment and top notch facilities, helping you develop into an independent scientist.

Project details: tinyurl.com/CosterPhD

Apply: tinyurl.com/ApplyICR

The lab: CosterLab.com

Join us in a highly collaborative environment. At the IMP everything is possible.

Our brilliant @louieaspinall.bsky.social and Tom are representing our Facility at #PSDI in Basel sharing how Cryo-EM at Leeds can support your drug discovery projects.

If you’re at the conference, come say hi before it wraps up!! 👋

Chromatin fatigue: DNA repair alters the chromatin environment and introduces heritable variation in gene expression in a larger region around the lesion! Amazing achievement by @sbantele.bsky.social and Jiri Lukas published in @science.org 🙌 Happy we could contribute. See 👇

Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds on FindAPhD.com PhD Project - Stopping GLI transcription factors in their tracks: identifying regulators of proteolysis as therapeutic targets. at University of Leeds, listed on FindAPhD.com

We have a fully funded studentship to start your PhD in October 2026! Work with me, Elton Zeqiraj and Joe Cockburn to find new ways to treat diseases with high levels of Hedgehog signalling. Fantastic training in cell and structural biology, genomic screening and biochemistry at the Uni of Leeds!

Have a look at this Tools of the Trade Article I wrote for @natrevmcb.nature.com on decoding #ubiquitin signals inside cells using UbiREAD!
Many thanks to @lisaheinke.bsky.social for the opportunity to write this TotT!