Sebastian Urbano

DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation Wang et al. reveal a role of DNMT1, traditionally known for DNA methylation, in regulating mitochondrial health through RNA modification. Their findings explain how the mutation in DNMT1 disrupts cellular energy metabolism, contributing to neurological disorders, and suggest therapeutic potential targeting RNA methylation in neurodegenerative diseases.

Online Now: DNA methyltransferase 1 modulates mitochondrial function through bridging m5C RNA methylation Online now:

07.05.2025 15:20 — 👍 4    🔁 2    💬 0    📌 0

ENPP1 governs the metabolic regulation of effector T cells in autoimmunity by detecting cytosolic mitochondrial DNA @cp-cellreports.bsky.social
www.cell.com/cell-reports...

14.06.2025 16:37 — 👍 8    🔁 4    💬 0    📌 0

Dynamic DnaA-DnaB interactions at oriC coordinate the loading and coupled translocation of two DnaB helicases for bidirectional replication https://www.biorxiv.org/content/10.1101/2025.06.05.657979v1

07.06.2025 03:19 — 👍 2    🔁 1    💬 0    📌 0

Mitochondria- and ER-associated actin are required for mitochondrial fusion - Nature Communications The actin cytoskeleton is crucial for cell and organelle motility. Here, the authors show that actin acts upstream of the mitochondrial fusion machinery to bridge two fusing mitochondria.

Mitochondria- and ER-associated actin are required for mitochondrial fusion - Nature Communications

congrats @manorlaboratory.bsky.social & CO

www.nature.com/articles/s41...

09.01.2025 10:50 — 👍 56    🔁 12    💬 1    📌 0

Endogenous mitochondrial NAD(P)H fluorescence can predict lifespan - Communications Biology Endogenous mitochondrial NAD(P)H fluorescence enables label-free and subcellular resolution quantification of aging, prediction of remaining lifespan and tracking of age-dependent changes to mitochond...

Cool new work from the lab by @chris-morrow.bsky.social: Often we think of auto-fluorescence as a hindrance to experiments - but endogenous metabolites have specific fluorescence we can use to determine the metabolic state of the cell - and predict lifespan.. www.nature.com/articles/s42...

22.11.2024 14:59 — 👍 85    🔁 29    💬 2    📌 4

Cryo-EM map and atomic model of the RAVE complex (regulator of ATPases of endosomes and vacuoles) bound to a partial V1-ATPase complex

Atomic model showing that the RAVE complex binds to a region of the V1 complex subunit A not found in the homologous ATP synthase subunit beta.

Most protein complexes are born only once. V-ATPase assembles over and over as part of its regulatory mechanism, enabled by RAVE (regulator of ATPase of vacuoles and endosomes)
@hanlinw222.bsky.social's 1st struct of RAVE bound to a partial V1 complex now out in PNAS.
www.pnas.org/doi/10.1073/...

03.12.2024 19:34 — 👍 62    🔁 14    💬 1    📌 0

Hi! I would like to be added to the starter pack. Thank you!

28.11.2024 16:19 — 👍 1    🔁 0    💬 1    📌 0

Hi! I would like to be added to the starter pack. Thank you!

28.11.2024 16:19 — 👍 1    🔁 0    💬 1    📌 0

Hi! I would like to be added to the starter pack. Thank you!

28.11.2024 16:18 — 👍 0    🔁 0    💬 1    📌 0

Hi! I would like to be added to the starter pack. Thank you!

28.11.2024 16:14 — 👍 1    🔁 0    💬 1    📌 0

Hi! I’m a PhD student at the Hernandez Lab @ Tufts. I’m into polymerases, helicases, non-B DNA structures, and metabolism—all the cool science! I also love computational modeling and understanding the molecular details that power life.

28.11.2024 06:59 — 👍 2    🔁 1    💬 0    📌 0