Vincent Tse

WTI Postdoctoral Fellowship applications are open! Unique opportunity for those pivoting fields or working across disciplines. I’d be happy to support candidates with a background in immunology and/or in vivo 2-photon imaging, including collaborations with other WTI labs wti.yale.edu/initiatives/...

Top: Example confocal micrograph showing astrocyte expression of S100β (green), Cre-RFP (magenta), and H1R mRNA (cyan). Left: summed z-projection of all three confocal channels. Middle: RNAscope detected H1R mRNA with white and yellow arrows indicating example WT (S100β+/RFP−/H1R+) and cKO (RFP+/H1R−) soma regions of interest (ROIs), respectively. Right: Cre-RFP expression (top, magenta) and S100β expression (bottom, green). Scale bars = 10 μm. Bottom: Example confocal micrograph showing astrocytic Cre-RFP (magenta), neuronal NeuN (green), and nuclear marker DAPI (blue). Left: summed z-projection of all three confocal channels. Middle: astrocytic Cre-RFP signal with astrocyte soma ROIs overlaid. Right: NeuN signal with astrocyte soma ROIs overlaid. Scale bars = 50 μm.

What's the function of #histamine -1-receptors (H1Rs) on cortical astrocytes? @kiraposkanzer.bsky.social & co show that astrocytic H1R signaling modulates Ca2+ activity, extracellular adenosine & REM #sleep, revealing a key #astrocyte role in sleep-wake regulation @plosbiology.org 🧪 plos.io/4gRj9Ap

Really excited to see this work from my postgrad days come out of its "slumber" 💤 If you are interested in how astrocytes interact with neuromodulatory systems to regulate cortical states, this is for you!

Cortical astrocyte histamine-1-receptors regulate intracellular calcium and extracellular adenosine dynamics across sleep and wake While histamine-1-receptor (H1R) signaling in neurons regulates arousal, these receptors are also abundant on cortical astrocytes. This study shows that astrocytic H1R signaling modulates calcium acti...

Congrats to Charlotte Taylor and team for dissecting how astrocyte networks integrate histamine to modulate adenosine over sleep and wake in unexpected ways:

dx.plos.org/10.1371/jour...

@vincenttse.bsky.social @maxine.science @trishavv.bsky.social

Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

Cool work @lester-rodriguez.bsky.social ! Congrats 🎉

Postdocs: Apply now for the SYNAPSES series @kavliatyale.bsky.social @yaleneuro.bsky.social! Deadline to apply is September 7th

Yale School of Medicine seeks a tenure track faculty member to research neuroinflammation in Alzheimer’s, bridging disciplines within a vibrant, collaborative community. Closing date: 31st October

www.dementiaresearcher.nihr.ac.uk/job/associat...

Cell-type-directed network-correcting combination therapy for Alzheimer’s disease A multi-cell-type drug discovery strategy targeting dysregulated gene networks in neurons and glia identified letrozole and irinotecan as a combination therapy that significantly improved memory and r...

The Sirota & Huang labs identified a novel letrozole–irinotecan combination therapy that improves memory and reduces pathology in Alzheimer's disease models—showcasing a transformative drug discovery approach rooted in human transcriptomics and real-world clinical data www.cell.com/cell/fulltex...

In collaboration with @pebyale.bsky.social, WTI presents the 2025 Undergraduate Poster Symposium. Join us at 100 College Street on Wednesday, July 30, from 2-4 pm.

Faculty, students + trainees are encouraged to attend! Learn more: wti.yale.edu/event/2025-0...

#KnowTogether

Now on bioRxiv! Astrocytes in one brain region (cyan) communicate in expansive networks (magenta). Through tool development, tissue clearing, and many hours on our @zeiss-microscopy.bsky.social Z1, we now know these networks are repeatable across mice, plastic, and specific.
doi.org/10.1101/2025...

Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD - Nature A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.

Very proud of our new #SingleCell work on #PTSD and #MDD out in @nature.com today.
Paper: www.nature.com/articles/s41...
News and views: www.nature.com/articles/d41...
Press: medicine.yale.edu/news-article...
Data: doi.org/10.5281/zeno...
Code: github.com/mjgirgenti/P...

I am looking for a postdoc with an immunology background interested in joining a Yale neuroscience lab to study how the brain controls immunity. At Yale, we have a wonderful interdisciplinary & collaborative #neuroimmune community. Please reach out or share with anyone who might be interested!

Really cool work -- congrats to all the authors!

I have seen folks waste so much time by not properly planning research. Missed literature, missing controls, ignored hypotheses, etc. Lack of planning also produces bad science (e.g. analysis until significant). So I am writing an app. Looking for feedback. scientific-paper-planner-test.vercel.app

Lovely image, Andrew! Would you mind sharing the antibody you are using to stain phospho-tau? Thanks in advance.

Astrocyte ensembles manipulated with AstroLight tune cue-motivated behavior Nature Neuroscience - Using the AstroLight system, the authors reveal that astrocytic ensembles in the nucleus accumbens regulate cue-motivated reward behavior, demonstrating that selective...

Extremely proud to finally be able to present this work in the open🍾✨ We identify and manipulate astrocytic calcium-dependent ensembles in the NAc ✨✨ It gathers new tools, intense experiments and results that blowed our minds in the process at Navarrete's lab 🤯 Check it out! rdcu.be/d8qJi

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying cerebral plaque burden depending on the parental source of the transgene. Mice inheriting the transgene paternally...

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.

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Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls

Adding @tamarajafar.bsky.social
@schandralab.bsky.social
@toddc.bsky.social
@vincenttse.bsky.social

If you’re interested in understanding cognition and Neuroscience at Yale follow our starter pack .

If there are others that should be added let me know !

go.bsky.app/CqNL4be

I would like to join! Thank you so much

I would appreciate it if you could share this invitation and respond if you would like to join this group.

go.bsky.app/DXdNa8k

some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?

go.bsky.app/MHtJzeC

I would love to be added! Thank you so much

There are lots of us missing, but so many joining so quickly

Please do share, and comment below to be added

go.bsky.app/5f2V6L6

(microglia starter pack also here by @mancusorenzo.bsky.social - bsky.app/starter-pack...)

I would love to be added! Thank you so much