Neta Felsenthal

Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis - PubMed How tissues acquire complex shapes is a fundamental question in biology and regenerative medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) that extend and fuse to form the hubs of each canal. We find that conventional actomyosin-driven behaviors are not re …

ECM swelling pressure driving morphogenesis. Tumours can also accumulate high HA and cause pressure, I wonder how general this mechanism is across tissues.
pubmed.ncbi.nlm.nih.gov/34942099/

We had covered the history of traction force microscopy (TFM) earlier:
bsky.app/profile/epim...

But what about applying TFM into more physiologically relevant systems, such as those in 3D?

I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

We summarised the many roles of material phase transitions in development (and they are not just mechanical 🤔)

😂

Hello epithelial mechanics fans!! I’m Juanma @juanmagararc.bsky.social 👋 I work on cell mechanics (see celldynamicslab.com) and use Flipper-TR FLIM to probe membrane biophysics in cells.

Join me on this tour about Flipper: what it measures, strengths, advice, cool case studies, and cute drawings!

@marineluciano.bsky.social recreates intestinal Villi geometry by growing epithelial cells on wavy rolling substrates. Unexpected intrication of curvature effects is observed. Thanks to all! @caterinatomba.bsky.social @sgabriele.bsky.social @sciencesunige.bsky.social
www.biorxiv.org/content/10.6...

Cytoneme Imaging Tips and Tricks - FocalPlane Cytoneme Imaging Tips and Tricks - How to

Following on from her beautiful featured image post on FocalPlane, Christina Daly @christinaadaly.bsky.social shares her top tips for imaging cytonemes.
@labogden.bsky.social.
focalplane.biologists.com/2026/01/19/c...

Dimensionality of cell migration.

Cells can move along 1D tracks, in 2D sheets, confined between a hard surface and fluid (2.5D), and within a 3D tissue.

Pick the optimal cell migration assay for your application using our review paper here:

www.nature.com/articles/s41...

How can structures at the vertex of 3 cells have effects at the tissue level?

Join me, @laura-rustarazo.bsky.social, to explore how tricellular junctions (TCJs) act as local tension sensors and regulators of global tissue organization. 🧵⤵️ doi.org/10.1126/scie...

This photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition,

The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance

Iconic imo

New year, new beginnings! Join us for all things animal & plant devbio at the 2026 @bsdb.bsky.social meeting in Warwick!

Abstract submission closing NEXT FRIDAY 16th JAN - join us!

I'll be presenting about "Breaking Biological Barriers" at Night Science Seminar Series on 12 Jan. I'll also try to say some things you don't normally hear people say about the academic process... cassyni.com/events/TjxgV...

📣Registration deadline approaching !📣

Check out @embo.org @biologists.bsky.social workshop "biophysical & molecular mechanisms of animal homeostasis & repair" 6-10th April, with a fantastic lineup of speakers! meetings.embo.org/event/26-hom....

Register/Abstract submission by 10th January.

מלטונין, שוקולד וחשיפה לשמש

AI-empowered super-resolution microscopy: a revolution in nanoscale cellular imaging - Nature Methods This Review provides a comprehensive discussion of how methods in machine learning and computer vision have been used to improve super-resolution microscopy to gain insights into subcellular biology.

A thorough review of deep-learning approaches (I prefer that to "AI") for enhancing super-resolution microscopy by @orangeroad2017.bsky.social, Yang Zhang and colleagues in @natmethods.nature.com: doi.org/10.1038/s415...

Fuck it I don’t care anymore

Wow, this sounds like an incredible opportunity!

I’ve already highlighted this landmark #lipidtime paper by @nadlerlab.bsky.social & colleagues, but ICYMI, do read André’s thread — this study is a huge leap forward in understanding the logic of intracellular lipid flux & is a phenomenal example of #chembio probes 🤝 quantitative imaging 🤝 modeling!

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

🍀🔬

MSL10 is a high-sensitivity mechanosensor in the tactile sense of the Venus flytrap @natcomms.nature.com from Toyota lab.

www.nature.com/articles/s41...

What i meant is, can you utilize anything for post correction on already made movies?

Cell migration is a key cellular process that drives major developmental programs and diseases.

Different assays have been developed, but they are often used interchangeably.

In our new paper, we describe how to select the optimal assay.

More details here: www.nature.com/articles/s41...

Optimized murine sample sizes for RNA sequencing studies revealed from large scale comparative analysis - Nature Communications Determining the appropriate sample size (N) for bulk RNA sequencing experiments is critical to ensure reliable results. Here the authors perform an unusually large N experiment (N = 30 per group), ana...

"Results from experiments with N = 4 or less are shown to be highly misleading (...). For a cut-off of 2-fold expression differences, we find an N of 6-7 mice is required to consistently decrease the false positive rate to below 50%, and the detection sensitivity to above 50%"

Why are women more likely to get irritable bowel syndrome? New study provides clues Cells in the guts of female mice respond to estrogen by increasing pain signaling, researchers find

Of the hundreds of millions of people living with IBS worldwide, about two-thirds are women.

Now, researchers have identified a biological pathway in the guts of mice that may help explain this disproportionate toll—a finding that could one day lead to new treatments. https://scim.ag/3YD8H78

Not that long ago, in vivo mouse enhancer design was a dream. Today, it's a reality! Using transfer deep learning to design de novo synthetic embryonic enhancers active in the heart, limb, and CNS. Great collab with @alex-stark.bsky.social lab! @ucibiosci.bsky.social @impvienna.bsky.social

Attention scientists from all over the world🙃
The Call for Letters of Intent for #HFSPResearchGrants 2027 is now open! 🧪
Get your international & interdisciplinary team. It's time to put your bold research idea into practice!
🔗https://bit.ly/48VsGCG
📅 15 Dec 2025–26 Mar 2026
#sts #LifeSciences

This entire weekend

A Global Telehealth First: Women Help Women Begins Producing Abortion Pill Combipack The feminist telehealth provider Women Help Women cuts out pharma middlemen to make its new mifepristone-misprostol abortion pill combo pack.

Amazing!! Women Help Women (womenhelp.org) is manufacturing their own abortion pills in order to make abortion safer, simpler and more accessible across borders. They designed an eco-friendly combi-pack that's easier to mail discreetly and centred around women’s experiences and needs.

I ignored the strip.clip argument in #ggplot2 for way too long 😲

Combined with a small negative margin tweak, you can place facet labels inside each panel. A tiny trick that makes small multiples feel so much cleaner.

🔵 no manual coordinates
🔵 inherits theme styling
🔵 scales nicely when resizing

Have you heard about the Night Science Podcast, where we talk about the creative process of doing science? We explore this with discussions with brilliant scientists & philosophers and artists, to figure out the tricks of the creative scientific trade.
podcasts.apple.com/us/podcast/n...