🎉 Congratulations to the newest PhD from the lab, Balint Doleschall!

His work on combining scRNA sequencing and transsynaptic viral tracing techniques with barcoding will pave the way for dissecting neural circuits in human circuit development.

An excellent achievement!

#neuroscience #organoids

🎉 Congratulations to Nina Corsini and Oliver Eichmüller, researchers in Jürgen Knoblich’s lab at IMBA, who were recognized with the German Tuberous Sclerosis Foundation’s Award for their research on tuberous sclerosis using cerebral organoids. More: https://imba.science/3Jej5hy

Appreciate the article from @imbavienna.bsky.social and @impvienna.bsky.social for featuring our journey studying asymmetric cell division to cerebral #organoids 🙌 ⬇️

www.imp.ac.at/achievements...

Congratulations to postdoctorate Oguzhan Kaya! What a fantastic achievement 🎉🧠

#neuroscience #organoids

A huge congratulations to @saku-wong.bsky.social on this fantastic achievement! 🎉

Brain tissues, assemble! Inside the push to build better brain models With organoids, assembloids and a growing toolkit of bioengineering tricks, scientists are stitching together models of the developing human brain — and pushing the limits of realism and control.

"[W]e are more surprised by what organoids can do than what organoids can’t do." - @knoblich-lab.bsky.social

Elie Dolgin explores the world of brain #organoids & #assembloids for @nature.com 🧪

www.nature.com/articles/d41...

Congrats to Hyosang Kim on receiving an EMBO Fellowship! 🧠 What an excellent achievement.

Cerebral organoids display dynamic clonal growth and tunable tissue replenishment - Nature Cell Biology Lindenhofer, Haendeler, Esk, Littleboy et al. perform whole-tissue lineage tracing in human cerebral organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage siz...

#NCB2024
In May, @knoblich-lab.bsky.social & co performed whole-tissue lineage tracing in human #cerebral #organoids to reveal that a subpopulation of symmetrically dividing cells can adjust its lineage size depending on tissue demands. #CellBio2024
www.nature.com/articles/s41...

All data is easily accessible in our Vienna brain organoid data explorer. You can look for your favorite gene or search for entire biological processes based on GO Terms. Check it out: vienna-brain-organoid-explorer.vbc.ac.at

We also provide RNA-seq data for cell lines in all protocols across organoid development. We quantify sources of variability (1. organoid developmental stage, 2. protocol, 3. cell line) and provide early signatures consistent with protocol-driven organoid derivation.

By comparison with fetal reference data, we can show that protocol-driven cells largely match cell types found in vivo while cell line-driven cells contribute to in vitro specific cell types.

Using scRNA-seq and a new measure for comparing scRNA-seq datasets from various sources, the NEST-score, we find protocol-driven cells (generated from many cell lines) as well as outlier, cell line-driven cells (generated from a single cell line only) for each protocol.

We characterized four regional brain organoid protocols across several cell lines using scRNA-seq on mature organoids and RNA-seq over time to generate a large fraction of human brain cells in vitro.

Find the article here: www.biorxiv.org/content/10.1...

Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols Human brain organoids are powerful in vitro models for brain development and disease. However, their variability can complicate use in biomedical research and drug discovery. Both the specific protoco...

Excited to share our latest preprint (@biorxivpreprint) on brain organoid development. Lead by Julia Naas and Meritxell Balmaña (@txellbalmana) with Arndt von Haeseler, Christopher Esk (@christopher-esk.bsky.social) and colleagues across Vienna. @maxperutzlabs.bsky.social, @IMBA_Vienna, @CeMM_News.

We characterized four regional brain organoid protocols across several cell lines using scRNA-seq on mature organoids and RNA-seq over time to generate a large fraction of human brain cells in vitro.