Another great research talk today (online version this time!) from Martin Sikora on #ancient human #pathogens - from #plague to #pandemics and #zoonosis. Did lifestyle shifts shape #disease #burden over time? Seems like it!
Thanks for joining us! #AncientDNA

Wrapped up yesterday's lectures with a canal tour in #Copenhagen — sunshine (mostly), good vibes (lots), and... as we entered #Nyhavn, a beautiful rainbow appeared. 🌈🚤🇩🇰 #CanalTour #Summercourse25 #popgendk

On our second day of this year summer course we had Victor Moreno-Mayar talking about the #ancient population of #Rapa #Nui. Was the data consistent with the population #collapse proposed so far? The biological data seems to disagree!
Thanks for joining us and thanks Victor for the incredible talk!

Alex Brown @blackochreomics.bsky.social from the @thekidsau.bsky.social gave a great talk on #indigenous #genomics and how to address health #inequality in these communities!
Thanks for joining us!

Just a few more days left to sign up for the EPIC conference 2025! Join us in Aarhus this August 🥳
✍️Registration deadline for talk/poster: 1st June 2025
✍️Registration deadline for attendance : 31st July 2025
#EPICdk25

This is a physical course but an online version will be available for those who can’t attend. We especially encourage students from African institutions to join online as this is offered as part of the African BioGenome Project Open Institute East&Central Africa Regional Workshop

Congratulations and thanks to all co-authors, especially to the two co-first authors @erillgenis.bsky.social and Shanlin Liu for starting and leading this project and the seniors @aalbrechtsen.bsky.social, Tom Gilbert and Rasmus Heller.

We also found that the gradual decline caused extremely low genetic diversity and strong purging of genetic load.
Combining these two populations could reduce the otherwise high realized genetic load and increase species viability

We generate a de novo genome sequence for a male saola and sequenced 26 recently discovered and near-extinct saola samples.
We found two highly differentiated populations that diverged and gradually declined over >5,000 years ago.

Genomes of critically endangered saola are shaped by population structure and purging The generation of whole-genome sequencing data from 26 saolas provides insights into the phylogenetic placement, population structure, historical decline, and genetic diversity in one of the world’s m...

We sequenced and analyzed the world's rarest large mammal, the #saola 🦄. That turned into a cool paper substantially increasing what we know about this elusive animal, its evolutionary history, population structure, and long-term decline.
Check it out here 👇 www.cell.com/cell/fulltex...

Are you an evolutionary/population geneticist in Denmark? The EPIC conference is back and it will take place on 11-12 August 2025 in Aarhus. Come along for two days of great talks and networking! #EPICdk25

Hosts: @molbiolau.bsky.social & @popgendk.bsky.social
Register now at: popgen.dk/epic/

Featuring lectures & talks by Martin Sikora, Shyam Gopalakrishnan @shyamsg.bsky.social , Katia Bougiouri @katiabou.bsky.social , Fernando Racimo, Ida Moltke @idamoltke.bsky.social and Anders Albrechtsen @aalbrechtsen.bsky.social

Our population genetics PhD summer course 2025
@popgendk.bsky.social, Globe_UCPH is open for registration!
We'll cover multiple topics and tools commonly used in PopGen analyses.
For more info: 🔗 website.popgen.dk/summer/

🦒🧬 New preprint🦒🧬
We investigated the degree of admixture, genetic diversity and inbreeding in ex situ giraffes using WGS data from the famous Marius, 12 zoo giraffes, and a data set from 71 wild giraffes.
#ConsGen #PopGen #Genomics #Giraffes #Marius
www.biorxiv.org/content/10.1...

Welcome back to our monthly #EPIC seminars!
We started yesterday with two speakers, Evelyn Todd and Marta Ciucani, talking about their research on #Scandinavian #wolves 🐺 and #African forest #hogs 🐗

Next seminar 🔜 May 21st
Join us for some interesting talks and pizza 🍕

Genetic architecture in Greenland is shaped by demography, structure and selection - Nature We illustrate that including data from Greenlandic Inuit can greatly reduce inequity in genomic-based healthcare in Greenland and other indigenous Arctic populations.

Really fascinating bit of work on #genetics of #Greenland - it really demonstrates why it's important to include people from diverse origins in genetic databases, but more importantly, it's also about HOW to include indigenous people in research + data sovreignty.
: www.nature.com/articles/s41...

Genetic architecture in Greenland is shaped by demography, structure and selection - Nature We illustrate that including data from Greenlandic Inuit can greatly reduce inequity in genomic-based healthcare in Greenland and other indigenous Arctic populations.

Nature research paper: Genetic architecture in Greenland is shaped by demography, structure and selection

https://go.nature.com/42Sc7pN

Genetic data from Indigenous Greenlanders could help to narrow health-care gap Population genetics for the Greenlandic Inuit.

The study is the result of a long and close collaboration with Steno Diabetes Center Greenland, Centre for Public Health in Greenland, and the University of Copenhagen. Also read the @NatureNV news and views: nature.com/articles/d41586-025-00091-6 and News www.nature.com/articles/d41... 🧵6/6

Increased proportion of common variants results in twice as many high impact associations in Greenland compared to Europe. Many of these are Arctic-specific. The impact is measured as variance explained; a combination of allele frequency and effect size. 🧵5/6

The variant distribution is different: Overall fewer variants in the Greenlandic population but a larger proportion of common variants. At the same time, the additive genetic burden is comparable between all populations. 🧵4/6

Representation of Greenlandic summary data drastically improves the expected outcome of clinical screenings and the predictive power of polygenic scores. 🧵3/6

We can inform health-care decisions in other Arctic populations, only using data from the Greenlandic population: Our analysis suggests that sucrose-intolerance might be present in the indigenous Alaskan populations. 🧵2/6

Genetic architecture in Greenland is shaped by demography, structure and selection - Nature We illustrate that including data from Greenlandic Inuit can greatly reduce inequity in genomic-based healthcare in Greenland and other indigenous Arctic populations.

The Greenlandic population offers significant potential for precision medicine. The largest analysis of its kind is now in @Nature. A big thank you to all participants in the health surveys throughout the last 25 years 🙏 www.nature.com/articles/s41... 🧵1/6