Tuuli Lappalainen

Tuuli Lappalainen

@tuuliel.bsky.social

Professor at KTH, NY Genome Center, SciLifeLab, working on functional genomics and human genetics.

6,923 Followers 897 Following 383 Posts Joined Sep 2023
1 day ago
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Köyhyys | Ruokaa ei riitä, joten ruokajono Helsingin Myllypurossa lopetetaan Hävikkiruokaa ei ole enää tarpeeksi jaettavaksi, joten Myllypuron leipäjonona tunnettu ruoka-apu lopetetaan kokonaan.

Suomalainen dystopia nousi sitten seuraavalle tasolle.

Ruokajono, joka perustettiin 30 vuotta sitten tilapäiseksi avuksi, lopetaan nyt, koska tarve ruoka-avulle on niin huutava, ettei siihen pystytä enää vastaamaan vaan liian moni avunhakija on pitänyt käännyttää pois.

www.hs.fi/helsinki/art...

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6 days ago
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success.

Data source: https://report.nih.gov/nihdatabook/report/302

The data is in: the NIH goalposts have shifted.

What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.

Another manifestation of how HHS policies have led to fewer awards and less science.

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6 days ago

The difference between Finnish and EU average unemployment rate.

The red line marks the time the most right wing government in Finnish history replaced Sanna Marin’s center left government.

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1 week ago

Oma kokemus lähinnä pandemiakeskusteluista, mutta silloin otin linjaksi että vastailen tasan kun itseä huvittaa/kiinnostaa, muut vaan miettimättä ohitan. Tietty avoimessa somessa saa kaikenlaisia kommentteja ja täggäyksiä eikä niistä kannattaa välittää/valittaa. Alatyylisistä toki blokki.

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1 week ago
Research engineer - Uppsala University Research engineer, Department of Organismal Biology, Uppsala University

The @scilifelab.se Ancient DNA Unit is recruiting a (permanent) Research Engineer for planning user projects and generating #aDNA 🧬 data:

Application deadline: March 25th 🧪🏺

www.uu.se/en/about-uu/...

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1 week ago

Made a short video as a response. 3 questions remain for me.

1) What is the definition of a "DEl activity," and how is it being communicated to NIH staff so they can determine whether a grant qualifies?

(Continued below)

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1 week ago

In my utopian vision of the future, instead of offloading all the pointless, annoying work tasks (like reports that none one will read and needlessly opaque forms) to robots, we restructure work and society so that the pointless tasks don't happen at all.

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1 week ago
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White House stalls release of approved US science budgets The US Congress rejected sweeping cuts to science agencies. But the NIH, the NSF and NASA have had their spending slowed.

Congress rejected massive cuts to US science budgets for 2026, but much of the money still isn’t flowing to researchers.

The culprit? The White House Office of Management and Budget (OMB) is quietly slow-walking the release of funds. 🧵👇

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2 weeks ago
Bioinformatician/Staff Scientist in Medical Genomics Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

I have an opening for a staff scientist or bioinformatician in my group at the Sanger Institute (closing date 24 March). Our current projects focus on disentangling rare and common variant contributions to rare neurodevelopmental conditions and to neurodevelopmental and perinatal traits. 1/2

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2 weeks ago

I understand why chatbot cheating happens but every time I read about it I want to gently remind everyone that the point of schoolwork is not for the submission to exist. Teachers are not just greedy for more essays or solved equations. The point is to do the work WITH YOUR OWN BRAIN, FOR LEARNING.

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2 weeks ago

Minua alkaa oikeasti pelottaa, että suomalainen eliitti ja media ei tajua sitä, kuinka todella pihalla valtavirtainen makrotaloustiede on taloudellisesta todellisuudesta. Yli 10 prosentin työttömyydessä siunataan jopa 15 mrd. euron sopeutusta tuleville vuosille odottaen suhdanteen korjaavan.
#tiede

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3 weeks ago
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The culmination of a lot of excellent work, @marlmatos.bsky.social defending her PhD thesis today. Co-mentored by @tuuliel.bsky.social, exceptional insights into molecular quantitative trait loci in CD4+ T cells

@einsteinmededu.bsky.social

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3 weeks ago
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pretty stunning chart

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3 weeks ago

The political lesson of the last 20 years is that when putatively left-of-center parties promise voters hope and change, but then deliver more of the same, it ends up creating the backlash conditions for right-wing authoritarianism.

It’s a very straightforward truism.

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3 weeks ago

Upeeta kun ensin talouskurin opeilla leikataan Suomesta kaikki kasvun edellytykset ja sitten kun kasvua ei kuulu niin siihen tarjotaan lääkkeeksi samaa talouskuria.
Onko suomalaiset oikeesti näin tyhmiä, vai pelkästään Hesarin pääkirjoitustoimitus?

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1 month ago
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Happy birthday to one of my favourite haters, Charles Darwin

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1 month ago

This is super cool science, empowered by our infrastructure team at @scilifelab-ngi.bsky.social @scilifelab.se !

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1 month ago

AI bot writes emo blog about not getting to play coder on GitHub… we are literally re-creating simulacrum of the most cringe ppl on the internet…

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1 month ago

Congratulations!!

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1 month ago

🖥️🧬🚀 I am excited to share that our #omnideconv study is finally published on Genome Biology: doi.org/10.1186/s130...

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1 month ago
⚡️ NEW: Jeffrey Epstein Recruited NSA Codebreakers for Genome “Manhattan Project”

The financier pursued cryptographers to “hack” the genetic code, and develop “new signals intelligence” to understand inter-cellular communication.

Story for Drop Site by 
@ryangrim
, 
@MazMHussain
, and 
@emilyjashinsky
https://www.dropsitenews.com/p/jeffrey-epstein-recruited-nsa-codebreakers-genome-russia-skolkovo-bill-gates-mit

⚡️ NEW: Jeffrey Epstein Recruited NSA Codebreakers for Genome “Manhattan Project”

The financier pursued cryptographers to “hack” the genetic code, & develop “new signals...

Story for Drop Site by @ryangrim.bsky.social, @mazmhussain.bsky.social & Emily Jashinsky

www.dropsitenews.com/p/jeffrey-ep...

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1 month ago
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Yesterday the UK Government published a data provision notice paving the way for coded GP data in England to be shared with consented cohorts like UK Biobank.

Hear from Val, a UK Biobank participant on her hopes for the future.

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1 month ago
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The Biology of Genomes Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Reminder that the abstract deadline for the Biology of Genomes meeting at CSHL is on Feb 13! We have a fantastic lineup of keynote speakers (Janet Kelso and Jonathan Pritchard) and session chairs. Submit your best science to this exciting and engaged meeting!
meetings.cshl.edu/meetings.asp...

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1 month ago
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🧬 New preprint alert! After years of collaborative work across 52 datasets we are presenting eQTLGen phase 2: a genome-wide eQTL meta-analysis covering 43,301 blood samples: www.medrxiv.org/content/10.6... (1/8)

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4 months ago

We're excited to be recruiting an NIH funded postdoc to work in the Coop lab at UC Davis. We're specifically interested in candidates who are want to work at the intersection of human genetics, GWAS, and population genetics modeling. Please RT

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1 month ago

The lesson for all the students out there is that science is a community project. Most of us make individually small contributions to this project. Success is measured at the collective level. Many of our professional (and personal) dysfunctions could be fixed by more fully embracing this view.

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1 month ago
Albert Einstein College of Medicine hiring Postdoctoral position studying functional non-coding variants in neurodevelopmental disorders, Bronx, New York City, USA c in New York City Metropolitan Area... Posted 9:40:20 PM. A postdoctoral fellow position is open with 2 years of funding from the Simons Foundation Autism…See this and similar jobs on LinkedIn.

Please share this with your network: Postdoctoral position available in my group.

www.linkedin.com/jobs/view/43...

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1 month ago
Albert Einstein College of Medicine | Medical Education | Biomedical Research

Please share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine.

faculty-einstein.icims.com/jobs/17847/a...

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1 month ago

I think it's best for everyone to understand that the unified class project of billionaires right now is to do to white collar workers what globalization and neoliberalism did to blue collar workers.

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1 month ago

I started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.

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