Jimmy

If this person sat next to you on a bus or train and started ranting about Bruce Springsteen in this way, you would get up and move to a different seat.

In the United States, we have him the nuclear codes.

RFK Jr. says HHS will determine the cause of autism by September

Science does not work like this. The only way you can set a timeline is if you have rigged the results in advance.

Original 1925 jacket cover of The Great Gatsby The Great Gatsby Here is a novel, glamorous, ironical, compassionate a marvellous fusion into unity of the curious incongruities of the life of the period which reveals a hero like no other one who could live at no other time and in no other place. But he will live as a character, we surmise, as long as the memory of any reader lasts. "There was something gorgeous about him, some heightened sensitivity to the promises of life. .. It was an extraordinary gift for hope, a romantic readiness such as I have never found in any other person and which it is not likely I shall ever find again?" It is the story of this Jay Gatsby who came so mysteriously to West Egg, of his sumptuous er-tertainments, and of his love for Daisy Buchanan a story that ranges from pure lyrical beauty to sheer brutal realism, and is infused with a sense of the strangeness of human circumstance in a heedless universe. It is a magical, living book, blended of irony, romance, and mysticism. CHARLES SCRIBNER'S SONS The GREAT GATSBY FITZGERALD

They were careless people, Tom and Daisy- they smashed up things and creatures and then retreated back into their money or their vast carelessness or whatever it was that kept them together, and let other people clean up the mess they had made.

-FS Fitzgerald, The Great Gatsby, published 4/10/1925.

The worst catastrophes of history are caused by men who are malevolent, ignorant, and have exceptional wills.

Just learned that the entire division of blood disorders at the CDC was put on administrative leave or terminated effective immediately.

The people who figured out HIV was infecting people through the blood supply.

What could possibly go wrong?

“This is our documentary moment” @janefonda.com

Cleveland, Ohio Lit Tonight in Solidarity with Ukraine

New plan to fight back against private insurance denials:

Doctors when you plan to retire, go get hired by UHC, Anthem, etc, and then once you are in the door, approve absolutely everything until you are fired.

Ice Melting on the Cuyahoga River in Cleveland, Ohio

Hey man sorry to hear about all your political turmoil. Would it help if I scrolled around on the computer all day and drove myself insane?

Website preview of article.

Viewpoint: Medical students and residents need to be educated on health policy issues like insurance, payment models, and drug regulation to better understand the factors that impact patient health outcomes.

https://ja.ma/3BuTE7P

Updates on #hemophilia gene therapy! 🩸 🧬

4 years post-treatment, valoctocogene roxaparvovec shows sustained bleed reduction, FVIII expression, and improved quality of life in severe hemophilia A patients. Safety remains acceptable, though some resumed prophylaxis.

https://buff.ly/3BBy3ui

Iron deficiency resolution and time to resolution in an American health system Key PointsIn a statewide cohort, time to resolution of iron deficiency was 1.9 years, and 58% of patients did not achieve resolution within 3 years.Greater

That feeling when you see your former @ash-hematology.bsky.social mentee in systems-based hematology publishes a GREAT study on iron deficiency anemia in @bloodadvances.bsky.social. I'M SO PROUD OF YOU DR. COGAN!!!
doi.org/10.1182/bloo...

Screengrab of the full HTML view of a new article in CA entitled "Cancer care for transgender and gender-diverse people: Practical, literature-driven recommendations from the Multinational Association of Supportive Care in Cancer." Read the article for free: https://acsjournals.onlinelibrary.wiley.com/doi/full/10.3322/caac.21872

New in CA: A Cancer Journal for Clinicians! 📕 This review offers practical recommendations for delivering quality cancer care to transgender & gender-diverse individuals. Read for free: acsjournals.onlinelibrary.wiley.com/doi/10.3322/... @drdonsdizon.bsky.social @oncoalert.bsky.social #oncsky

Is it allowed to say we had a fantastic educational session on #hormone related #VTE with Dr Leslie Skeith and Dr Joseph Shatzel #ASH24? A packed room and loads of interaction. Sorry we couldn’t handle all online questions 🤷🏻‍♀️.

#ASH24 #bmtsm Brissot: EBMT analysis of haplo <40yo vs MSD >50yo allo in ALL pts age 45+, all in CR1. Similar outcomes for RFS/OS. More relapse with MSD, more NRM with haplo — effects cancel each other for long term outcomes.

An amazing oral presentation of our #AMLsm #AYA #healthdisparities work by super-star resident Dr. Erin Feliciano 🌟#ASH24 #ASHTrainee #ASHKudos @ash-hematology.bsky.social

A 🧵 on some of the highlights of our findings:

1/x

We appreciate the opportunity to present real-world data on thrombosis risk among patients with breast cancer who are receiving targeted therapies- it’s higher than expected! #ASH24 #HemeSky #bcsm

Session on genetic risk factors for #VTE #ASH24. First abstract presentation on ARIC cohort. CHIP (clonal hematopoiesis of indeterminate potential) is not rare but only modest increase for VTE in older adults. Key message: not worth screening for it.

Honorable mention #MajorPROsASH: PROs pts with bleeding d/o of unknown cause (BDUC)
- 97 pts completed RAND-36
- significantly worse phys health, energy, social fxn & pain in BDUC vs general population
Important findings in wholly understudied pt population. #ASH24 #hemetwitter

🩸Platelets!

Lifespan 7-10 days
150-450 × 10⁹/L
Stimulated by TPO
1/3 sequestered in spleen

Receptors:
GpIIbIIIa -> fibrinogen
GPIb-IX-V -> vWF
P2Y12 -> ADP

Granules:
Alpha = fibrinogen, vWF, V, VEGF, PF4, PDGF, P-selectin
Dense = ADP, Ca, Serotonin
#hemesky #MedSky

van der Meijden et al, 2019

2025 update on clinical trials in immune thrombocytopenia Summary of major novel and repurposed agents currently in clinical development for immune thrombocytopenia.

🩸 A fresh review on ITP for #hemesky #MedSky #IMsky #hemepath #ITP #lowplatelets

American Journal of Hematology | Blood Research Journal | Wiley Online Library
doi.org/10.1002/ajh....

The Duffy Null Phenotype — Addressing a Source of Discrimination in Cancer Care | NEJM Cancer research and care practices that adversely affect people with the Duffy null phenotype are an underrecognized and widespread source of discrimination against people of African or Arab ancestry.

If we ignore Duffy-null associated neutrophil counts (DANC), we contribute to major disparities in oncology care and clinical trial enrollment. Whether you’re a clinical trialist or clinician, a must-read from @laurenmerzmd.bsky.social and coauthors #medsky #hemesky 🩸🧪

www.nejm.org/doi/abs/10.1...

ASCT in CR1 MCL MRD-adapted #ASH24 @timfenske:
650 pts, 73% AraC induction, mFU 2.7 yr
- A: uMRD6 ASCT + MR x 3 yr
- B: uMRD6 MR x 3 yr
3-yr PFS/OS:
- A: 76.6%/82.1%
- B: 77.4%/82.7%
No difference in OS based on futility analysis. CR1 with MRD-neg at 10-6 do not need ASCT! #lymsm

10-15% of iTTP do not respond to rituximab. Targeting plasma cells can be promising.

In this study, durable responses to bortezomib were registered in 60% of multi-refractory iTTP patients, with mild-to-moderate toxicities.

www.jthjournal.org/article/S153...

#MedSky #HemeSky #TTP #bortezomib

Last Night’s Snow Storm in Cleveland, Ohio

Bluesky is emerging as the new platform for science - Mike Young Academy Scientific Twitter is about to find its true successor. And it is not X. This, our latest release, shows that the Bluesky network of scientists is growing — and growing.

A mapping of how Bluesky is becoming the new Scientific Twitter

mikeyoungacademy.dk/bluesky-is-e...

I couldn't find a starter pack for the hematology community so I created one:
go.bsky.app/8K9pgxU