Joel Steele 🧪💉⚡💥📹

Proteins are at least a known thing with a standard code. I dont know if Metabolites even truly exist 👀 haha
Don't need some unknown unknowns 🤣

26.02.2025 01:53 — 👍 0    🔁 0    💬 0    📌 0

Monash University's Proteomics & Metabolomics Platform Strengthens Partnerships with Seer and Thermo Fisher Scientific Monash University's Proteomics & Metabolomics Platform is set to revolutionise the field of proteomics and multiomics with its latest partnerships with Seer, Inc. and Thermo Fisher Scientific. This co...

🚀 Exciting times at Monash Proteomics & Metabolomics!

Our Proteograph XT Workflow (Seer) + second Orbitrap Astral (Thermo Fisher) are now live, 8,000+ proteins from human plasma! We can also do multiomics on these samples as well. Lipids & Metabolites!
Reach out at our website :-)

25.02.2025 07:57 — 👍 23    🔁 2    💬 1    📌 0

In-context genomic modeling and design with Evo.

120 billion base pairs of AI-generated genomic sequences with SynGenome.

Evo generates functional anti-CRISPR proteins with no homology to known proteins.

Evo generates functional toxin-antitoxin protein-protein interactions with remote homology to nature.

A protein's position in the genome in relation to other genes is informative about function, so a genomic language model can be prompted to generate
- toxin/antitoxin pairs
- anti-CRISPR proteins

+ a database of 120B synthetic base pairs

www.biorxiv.org/content/10.1...

@brianhie.bsky.social

18.12.2024 22:14 — 👍 60    🔁 19    💬 1    📌 0

🚨 Exciting research alert! 🚨

New #Proteomics study reveals ferroptosis as a key player in Fabry Disease. Using iPSC-derived podocytes, the team identified ALOX15 and ferroptosis as crucial in disease pathology. Could targeting ferroptosis unlock better treatments? 🌟

Details: shorturl.at/G0FHr

11.12.2024 02:23 — 👍 6    🔁 0    💬 0    📌 0

OUTSTANDING PAPER !!!!!

11.12.2024 02:09 — 👍 2    🔁 0    💬 0    📌 0

ProHap: A New Tool for Capturing Genetic Diversity in Proteomics

One proteome to rule them all? We have published a tool to create custom protein databases from large panels of genotypes in @naturemethods.bsky.social. Check the post below to see why it matters, why you should use it, and how it will make your life both easier and more difficult.

10.12.2024 03:41 — 👍 10    🔁 5    💬 2    📌 1

“The genetic architecture of protein stability” 🧪🧶🧬

An additive fitness prediction model trained on ≤2 mutations predicts fitness effects of 3-13 substitutions with R2=0.5

www.biorxiv.org/content/10.1...

28.10.2023 05:49 — 👍 8    🔁 3    💬 0    📌 0

Podcasting help: @proteomicsnews.bsky.social and I record shows remotely using Squadcast, and that works great. But as conferences approach we’ve talked about recording in-person. But I don’t know exactly how. Do we just hook up a bunch of mics and splitters to a MacBook? tascam? mixing board? Help!

06.10.2023 12:06 — 👍 5    🔁 4    💬 1    📌 0

I'm especially excited about this year's courses. The entire curriculum was shaken up, almost every course removed to make room for the new vision and directions of human proteome research! 🧪 🧬

04.10.2023 21:04 — 👍 8    🔁 2    💬 1    📌 0

I discovered this at the skyline course and have been trying to get my workflows into a form that I can use the MS stat's shiny to test the power

05.10.2023 00:03 — 👍 2    🔁 0    💬 0    📌 0

I recently developed a workflow for studying Myc levels and all its related proteins via tmt, worked quite well but I think that work is going to take along time to get published 😀 cool paper btw!

04.10.2023 23:55 — 👍 2    🔁 0    💬 1    📌 0

Thank you! Scored one many thanks to @justinwwalley.bsky.social

04.10.2023 23:52 — 👍 2    🔁 0    💬 1    📌 0

Large-scale plasma proteomics comparisons through genetics and disease associations - Nature Comparisons of phenotypic and genetic association with protein levels from Icelandic and UK Biobank cohorts show that using multiple analysis platforms and stratifying populations by ancestry improves...

Our comparison of two high-throughput plasma proteomics platforms is out today in Nature: www.nature.com/articles/s41...

By associating protein levels with diseases and genetic variants we demonstrate how differences between platforms can affect the conclusions drawn from experiments.

04.10.2023 16:46 — 👍 5    🔁 2    💬 1    📌 0

From volcanoes to the bench: Advantages of novel hyperthermoacidic archaeal proteases for proteomics... Here we introduce hyperthermoacidic archaeal proteases (HTA-Proteases©) isolated from organisms that thrive in nearly boiling acidic volcanic springs …

Inaugural #POTRHList on Bluesky, w/ @leannewg.bsky.social, @ucdproteomics.bsky.social and I (likely poorly threaded).

Vikas came on and talked about super cool (hot) alt enzymes for proteomics:
www.sciencedirect.com/science/arti...

1/n

04.10.2023 18:52 — 👍 6    🔁 1    💬 3    📌 0

Good blog post about how to approach the analysis of a two species proteomics experiment.

github.com/pwilmart/Hum...

04.10.2023 23:19 — 👍 8    🔁 2    💬 0    📌 0

Damn I didn't realise yall had one!!!! I could have came for once 😅
Also was reading about those enzymes last night very cool

04.10.2023 23:35 — 👍 0    🔁 0    💬 0    📌 0