Proteins are at least a known thing with a standard code. I dont know if Metabolites even truly exist 👀 haha
Don't need some unknown unknowns 🤣
🚀 Exciting times at Monash Proteomics & Metabolomics!
Our Proteograph XT Workflow (Seer) + second Orbitrap Astral (Thermo Fisher) are now live, 8,000+ proteins from human plasma! We can also do multiomics on these samples as well. Lipids & Metabolites!
Reach out at our website :-)
A protein's position in the genome in relation to other genes is informative about function, so a genomic language model can be prompted to generate
- toxin/antitoxin pairs
- anti-CRISPR proteins
+ a database of 120B synthetic base pairs
www.biorxiv.org/content/10.1...
@brianhie.bsky.social
🚨 Exciting research alert! 🚨
New #Proteomics study reveals ferroptosis as a key player in Fabry Disease. Using iPSC-derived podocytes, the team identified ALOX15 and ferroptosis as crucial in disease pathology. Could targeting ferroptosis unlock better treatments? 🌟
Details: shorturl.at/G0FHr
OUTSTANDING PAPER !!!!!
One proteome to rule them all? We have published a tool to create custom protein databases from large panels of genotypes in @naturemethods.bsky.social. Check the post below to see why it matters, why you should use it, and how it will make your life both easier and more difficult.
“The genetic architecture of protein stability” 🧪🧶🧬
An additive fitness prediction model trained on ≤2 mutations predicts fitness effects of 3-13 substitutions with R2=0.5
www.biorxiv.org/content/10.1...
Podcasting help: @proteomicsnews.bsky.social and I record shows remotely using Squadcast, and that works great. But as conferences approach we’ve talked about recording in-person. But I don’t know exactly how. Do we just hook up a bunch of mics and splitters to a MacBook? tascam? mixing board? Help!
I'm especially excited about this year's courses. The entire curriculum was shaken up, almost every course removed to make room for the new vision and directions of human proteome research! 🧪 🧬
I discovered this at the skyline course and have been trying to get my workflows into a form that I can use the MS stat's shiny to test the power
I recently developed a workflow for studying Myc levels and all its related proteins via tmt, worked quite well but I think that work is going to take along time to get published 😀 cool paper btw!
Thank you! Scored one many thanks to @justinwwalley.bsky.social
Our comparison of two high-throughput plasma proteomics platforms is out today in Nature: www.nature.com/articles/s41...
By associating protein levels with diseases and genetic variants we demonstrate how differences between platforms can affect the conclusions drawn from experiments.
Inaugural #POTRHList on Bluesky, w/ @leannewg.bsky.social, @ucdproteomics.bsky.social and I (likely poorly threaded).
Vikas came on and talked about super cool (hot) alt enzymes for proteomics:
www.sciencedirect.com/science/arti...
1/n
Good blog post about how to approach the analysis of a two species proteomics experiment.
github.com/pwilmart/Hum...
Damn I didn't realise yall had one!!!! I could have came for once 😅
Also was reading about those enzymes last night very cool
