Pascalis Vergidis, MD

Department of Medicine Staff Awards @mayocliniccancer.bsky.social

Honored to be a Member of the amazing CAR-T cell therapy team.

Mycology Lab for the medical students at Mayo Clinic Alix School of Medicine. We reviewed morphological differences between Aspergillus and Mucorales.

Included in this year’s Mycology Lecture for the medical students at Mayo Clinic Alix School of Medicine.
Trichophyton indotinae, an emerging fungal threat

Microbiology course at Mayo Clinic Alix School of Medicine. We reviewed 4 case of tuberculosis with a focus on social determinants of health.

Excellent discussion led by our social worker, Mariah Thompson, and Dr. Zami Temesgen, principal investigator Mayo Clinic Center for Tuberculosis.

Bacteriology Lab for the medical students at Mayo Clinic Alix School of Medicine led by Dr. Bobbi Pritt.

We had 12 stations. All about Gram stains and cultures! Note the green metallic sheen of E. coli on Eosin Methylene Blue (EMB) agar.

Introduction to Microbiology for the medical students at the Mayo Clinic Alix School of Medicine

We discussed this MMWR publication which brought us back to the onset of the #HIV epidemic.

Adjunctive corticosteroids in non-AIDS patients with severe Pneumocystis jirovecii pneumonia (PIC): a multicentre, double-blind, randomised controlled trial - PubMed French Ministry of Health.

pubmed.ncbi.nlm.nih.gov/40652952/

Looking forward to our journal club #MayoClinic Infectious Disease Fellowship. Adjunctive corticosteroids in hypoxemic patients with non-HIV Pneumocystis pneumonia. No difference in 28-day mortality. However, need for mechanical ventilation was lower in the steroid group.

As a member of the ABIM Infectious Disease Approval Committee, I would like to congratulate those who recently passed their Boards. You are all committed to delivering exceptional patient care and upholding the highest standards in Medicine.

How best to treat invasive aspergillosis? @pascalisid.bsky.social reviewing key clinical studies informing this choice - important to monitor vori levels , NB: AmB <vori=isavu @idweek.bsky.social #IDWeek2025 #TxID #IDSky

Please join us this Monday 8-9 am at IDWeek. Difficult-to-treat mold infections. Dimitrios Farmakiotis will be discussing treatment of mucormycosis. I will be discussing aspergillosis.

Home - Doctor Fungus Welcome to Doctor Fungus! An Educational Website of theMycoses Study Group Education and Research Consortium (MSGERC)   [View Legal Information] Where to Start Mycology Case of the Month An Introducti...

There’s now an app for all things fungi 🦠🍄
Dr. Matthew Pullen, Assistant Professor at the University of Minnesota, helped launch Dr Fungus—a free app that brings the trusted resource to your phone.

Explore fungal infections, antifungal treatments, and case-based learning—all in one place.

🆕 MMWR: In NYC, NDM-CRE just surpassed KPC-CRE for the first time.

And nearly 75% of these cases had no long-term care facility link

This is a changing landscape of antibiotic resistance - happening across US

#IDSky
📄: www.cdc.gov/mmwr/volumes...

Lateral flow device showing positive control (line at C but not T), negative control (line at both C and T), and a test sample (lines at both C and T shown). The test line (T) disappears when the antigen is present.

ROC for the lateral flow device for mucorales antigen TG-11. The AUC is 0.739

Detection of Mucorales antigen in BAL samples using a newly developed lateral-flow device

A Mucorales antigen test is sorely needed

This one had Sn of 76.92%, Sp of 75.51%, respectively, PPV 45.45%, and a NPV 92.5% (Not good enough but could augment qPCR)

journals.asm.org/doi/10.1128/...

Join us for a panel discussion on “Leveraging Partnerships to Fight Fungal Diseases” June 19
2.55-3.25 pm @ASMicrobiology
Dallas Smith @CDCgov
Sean Zhang, Fungal Diagnostics Laboratory Consortium
Rob Purdie, MYCology Advocacy, Research & Education
Zachary Rubin @lapublichealth
Me @MSG_ERC

Visited the historic city of Philadelphia to attend the American Board of Internal Medicine (ABIM) New Governance Orientation. Looking forward to serving on the Infectious Disease Approval Committee.

Of the profession, for the public

Virus-Specific T-Cell Therapy for Prophylaxis and Treatment of Cytomegalovirus Infections After Transplantation: a Scoping Review Cytomegalovirus-specific T cells have been used in studies of primarily adult hematopoietic stem cell transplant recipients. Heterogenous trial design and

Synthesis of the available literature on the use of CMV-specific T-cell therapy in adult and pediatric HSCT and SOT recipients.
Several patients on concurrent antivirals, which confounded the effectiveness of VSTs
@CIDJournal @transplantidnet.bsky.social

academic.oup.com/cid/advance-...

Dr. Jeniel Nett discussing biofilm at the 2025 Scientific Meeting on Candida auris @msgerc.bsky.social

Kaposi Sarcoma–Associated Herpesvirus Risk and Disease in Kidney Donors and Transplant Recipients With Human Immunodeficiency Virus in the United States The prevalence of Kaposi sarcoma–associated herpesvirus (KSHV) was high among kidney donor and transplant recipients with HIV. Posttransplant KSHV-associat

High Kaposi sarcoma-associated herpesvirus seroprevalence in donors and recipients with HIV, particularly among MSM. Reassuringly, disease was rare.
@transplantidnet.bsky.social

academic.oup.com/cid/advance-...

Safety and Efficacy of Pemivibart, a Long-Acting Monoclonal Antibody, for Prevention of Symptomatic COVID-19: Interim Results From a Phase 3 Randomized Clinical Trial (CANOPY) AbstractBackground. We report an interim analysis of safety and efficacy of pemivibart in individuals with (cohort A) or without (cohort B) significant imm

In a phase 3 clinical trial, pemivibart provided prophylactic efficacy against COVID-19 in immunocompromised patients and individuals at risk for exposure. Four of 623 participants experienced anaphylactic reactions @transplantidnet.bsky.social

academic.oup.com/cid/advance-...

Line graph showing year-to-year fluctuation but general increase in fluconazole resistance (lowest was 6% in 2018, highest was 21% in 2024), with slight increase in voriconazole and posaconazole resistance (up to 5% in 2024), and micafungin resistance that briefly reached 5% in 2023 before dropping again

Increasing Fluconazole Resistance in Candida parapsilosis: A 10-Year Analysis of Blood Culture Isolates at a US Reference Laboratory (2015–2024)

Fluco-R C parapsilosis ⬆️ from 8.2% to 20.3% in BCx isolates tested @ Mayo

Jack McHugh ... @pascalisid.bsky.social

academic.oup.com/jid/advance-...

This #TransDayofVisibility 🏳️‍⚧️

Please know:

We see you, & we will continue to fight for you.

ID Grand Rounds.

I discussed the following:
- ONE Health
- Aspergillus urine antigen
- Giant magnetoresistance-enabled PCR
- Rezafungin for prevention in bone marrow transplant
- Ibrexafungerp (FURI)
- Olorofim (Study 32)
- Our experience with fosmanogepix

In rare cases, vaping-associated lung injury (EVALI) may lead to irreversible damage requiring lung transplantation

Can filgrastim precipitate organ rejection ?

A Novel Giant Magnetoresistance–Enabled Multiplex Polymerase Chain Reaction Assay for the Diagnosis of Invasive Fungal Infection AbstractBackground. Despite advances in clinical microbiology, the diagnosis of invasive fungal infections remains challenging. Giant magnetoresistance (GM

We used Giant Magnetoresistance to diagnose invasive fungal infection. The assay has the potential to detect trace amounts of fungal DNA in serum

academic.oup.com/ofid/article...

You are right. Species identification was done at the Fungus Testing Laboratory UT Health San Antonio.

Aspergillus pseudodeflectus belongs to the Aspergillus section Usti. Can be multidrug resistant (similar to calidoustus) - Learning something every day!

I have to admit I do not know the answer to this question 😔