Immunology & Microbial Pathogenesis (IMP) Program

This was so fun! Thank you so much to @cindyleifer.bsky.social and @microbetv.bsky.social for the opportunity to discuss pregnancy immunology ✨

Congratulations to IMP faculty member Andrea Schietinger and her team on their latest study on the role of the transcription factor TOX in CD4+ T cell function.

Congratulations to IMP alum Rachel Gottschalk! We are extremely proud of you! 🎉

Huge congratulations to IMP Student @anaccodo.bsky.social of the @justinperryphd.bsky.social lab, on an exciting paper, find the aritcle here: www.sciencedirect.com/science/arti...! 🎉

Spotlight on Yoselin Paucar Iza, graduate student in the Brown Lab at MSK and HHMI Gilliam Fellow! 🌟Keep up the amazing work! 🔬

Congratulations to IMP faculty member Brad Jones and his team on their latest study published in @nature.com on how to target the HIV reservoir

I'm thrilled to share that the first paper from my PhD is out today in @cp-immunity.bsky.social!
Here, we investigated how phagocytes, such as macrophages, handle microplastics (MPs) during their normal functions.
www.sciencedirect.com/science/arti...

Excited to share that our paper was accepted at @insight.jci.org !

GATA2 controls alveolar macrophage inflammatory gene expression and metabolic function insight.jci.org/articles/vie...

New preprint out: prolonged TGF-β locks NK cells in a durable dysfunctional state through epigenetic remodeling.

Signal duration matters.

Outstanding team effort, with special thanks to Kevin Schmid for leading this work.

www.biorxiv.org/content/10.6...

New preprint!

TL;DR: Network analysis reveals that CEBP/β and PU.1 stabilize regulatory architecture in tissue-resident alveolar macrophages to constrain inflammatory responses

www.biorxiv.org/content/10.6...

Proud to once again ride in @cycleforsurvival.bsky.social in three weeks. 100% of every dollar I raise advances rare cancer research at @mskcancercenter.bsky.social. Every single dollar you give makes a difference. Donate here: shorturl.at/U92Sc

Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils The incidence of colorectal cancer (CRC) is elevated in individuals with inflammatory bowel disease. Pires et al. find that the cytokine TL1A stimulates production of GM-CSF by ILC3s, which triggers e...

Congratulations to IMP faculty member Randy Longman and his team on their study published in @cp-immunity.bsky.social

Press release:

news.weill.cornell.edu/news/2026/02...

Transcription factor Etv3 controls the tolerogenic function of dendritic cells Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...

Very happy to share the final chapter of my postdoc work with Boris Reizis @NYU @uchicagocoi.bsky.social published today in @science.org! We identify and define the role of transcription factor ETV3 in the tolerogenic function of dendritic cells (DCs). 1/

www.science.org/doi/10.1126/...

Our new paper about how the immune system is rewired when food availability is reduced! An awesome team effort by Luisa Menezes Silva, Mingeum Jeong and @seongji1.bsky.social.

Also, we're hiring Postdocs and Techs - please reach out if interested!

A great collaboration that came out a few weeks ago with the labs of CJ Guo and David Artis - led by Shanshan Qiao from the Guo lab.

Chromatin-mediated anticipatory control of type I interferon production in plasmacytoid dendritic cells Powerful interferon (IFN)-I-producing capacity distinguishes plasmacytoid dendritic cells (pDCs) from related innate cells. Adams et al. find that, during pDC development, the locus encoding IFN-I gen...

Why are pDCs so good at producing type I interferons? We set out to address this long unanswered question in our @cp-immunity.bsky.social study. A great collaboration between the Reizis Lab @NYU @uchicagocoi.bsky.social and @agalicina.bsky.social & Leonid Mirny @MIT 1/
www.cell.com/immunity/ful...

Congrats to former IMP student Nick Adams on this recent study (as a postdoc)!

Very happy to share our new study defining the ontogeny of Thetis cells and the developmental cues that shape their early-life wave of differentiation. www.nature.com/articles/s41... Beautiful work led by @hhmi-science.bsky.social Gilliam Fellow Yoselin Paucar Iza and postdoc Tyler Park 1/

Stepwise epigenetic signal integration drives adaptive programming of cytotoxic lymphocytes Lymphocyte differentiation during infection depends on the integration of antigen and cytokine signals, yet how the timing and sequence of these cues …

Excited to share my paper published today in @cp-immunity.bsky.social! We find that when CTLs integrate antigen and cytokine signaling, the timing of these cues matters - shedding light on an old question: Why do NK cells sometimes behave like CD8+ T cells?
www.sciencedirect.com/science/arti...

Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.

Researchers from the lab of MSK immunologist Dr. Gretchen Diehl are shedding new light on how intestinal stem cells sense microbes and protect the gut. Read their new study, just out in @science.org #ScienceImmunology.

Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophages Colonic stem cell TLR5 sensing of microbes promotes macrophage recruitment and maturation to support intestinal barrier repair.

Huge congrats to Ming-Ting Tsai on publishing his thesis work in Science Immunology! Ming-Ting dissects a mechanism of E. coli-driven intestinal barrier repair, highlighting TLR5 as a key receptor for recruiting CCR2+ macrophages to the colonic lamina propria. 🎉
www.science.org/doi/10.1126/...

👋 We’ll be more active here on Bluesky and share student and faculty accomplishments, program highlights, and other great things happening across IMP. Stay tuned! ✨

We’re 2 weeks into the new year, but it’s never too late to say Happy New Year from IMP! 🎉 Shoutout to our recent PhD defenses: Thais Klevorn (Sabine Ehrt Lab, Aug 2025), Ian Mantel (Laura Donlin Lab, Dec 2025), Louise Leyre (Brad Jones Lab, Dec 2025), and Winston Chang (Alan Hanash Lab, Jan 2026) 🎓

🚨Thrilled to share our latest work, published online today
@nature.com in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort
@mskcancercenter.bsky.social led by superstars Varun Narendra + @tandriladas.bsky.social 1/

www.nature.com/articles/s41...

Our IMP Retreat also featured an exciting poster session showcasing outstanding research from our students and postdocs. Congratulations to this year’s poster award winners for their excellent presentations and contributions to our vibrant scientific community!

IMP Program held its annual scientific retreat last week, we heard presentations from our faculty, students, and postdocs. A keynote address by Dr. Brian Brown from the Icahn School of Medicine. Though held locally on campus this year, it was an engaging celebration of our program community!

Antigen-presenting cells as arbiters of mucosal tolerance and immunity Nature Immunology - Brown and colleagues review the heterogeneity of mucosal antigen-presenting cells that orchestrate T cell immunity to intestinal antigens.

Excited to share our review on Thetis cells and dendritic cells, and their roles in mucosal immunity and tolerance @natimmunol.nature.com rdcu.be/eLtB1

Sound advice from IMP faculty member Roberta Zappasodi:

“be creative in your science, but be equally inventive—and strategic—in how you chart your course toward the research program you want to build.”