Immunology & Microbial Pathogenesis (IMP) Program

Fantastic to see two former IMP postdocs @thepenkpanther.bsky.social and @coraline-mly.bsky.social highlighted by JEM in this Viewpoint! #WomeninSTEM

TCF19 drives a broad transcriptional program that potentiates optimal innate and adaptive functions of antiviral NK cells - Nature Immunology Sun and colleagues report that the transcription factor TCF19 regulates calcium signaling and cell cycling progression in NK cells and is required for innate and adaptive NK cell responses to viral in...

Have a look at this new study by Dr. Celeste Dang in @natimmunol.nature.com showing an interesting new role for the transcription factor TCF19 in driving antiviral NK cell function. Congrats Celeste for driving this one to the finish line! @mskcancercenter.bsky.social

The 2025 Gilliam Fellows & Advisors | HHMI The Gilliam Fellows Program launches promising PhD students into impactful scientific research careers while fostering inclusive training environments.

Thrilled to share that I was selected for the @hhmi.org Gilliam Fellowship! Extremely grateful to my PI @justinperryphd.bsky.social and my lab mates (Jesús and Shasha) for their incredible support! Excited for many discoveries and outreach within @wcm-imp.bsky.social

www.hhmi.org/programs/gil...

Check out this nice highlight from @weillcornell.bsky.social

PD-1 is requisite for skin TRM cell formation and specification by TGFβ - Nature Immunology Anandasabapathy and colleagues show that the inhibitory receptor PD-1 impacts the specification of tissue-resident memory T cells in the skin.

Exciting first post! With @drshrutinaik.bsky.social and many others! www.nature.com/articles/s41...

Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...

Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab @mskcancercenter.bsky.social
Here is a short paper thread. #tuberculosis #macrophages 🦠
www.biorxiv.org/content/10.1...

It's official. I'm happy to announce that I have been promoted to Associate Member @mskcancercenter.bsky.social. It is sincere when I say that this would not have been possible w/o the incredible work of the members of my lab. In fact, exciting news about them coming soon. Stay tuned.

Congratulations 2025 ICIS Young Investigators! - Biweekly newsletter of the International Cytokine & Interferon Society The International Cytokine & Interferon Society proudly announces these 2025 Young Investigator Award winners. The Sidney & Joan Pestka Graduate and Post-Graduate Awards, sponsored by PBL Assay Services Post-graduate awardee, Alexander Lercher, PhD, The Rockefeller University is currently an HFSP long-term fellow and Harvey L. Karp postdoctoral fellow in the laboratory of Charles M. Rice

🎉Huge congrats to Kathleen Mills, PhD, on being named a 2025 ICIS Young Investigator Awardee! Her success reflects the drive and excellence we see across our IMP students! You've done amazing work in the Hohl lab.👏We wish you the best, onward and upward! signals.cytokinesociety.org/2025/07/14/2...

Macrophage-derived oncostatin M repairs the lung epithelial barrier during inflammatory damage Tissue repair programs must function alongside antiviral immunity to restore the lung epithelial barrier following infection. We found that macrophage-derived oncostatin M (OSM) counteracted the patho...

🎉 Over the moon to share the first paper from my lab!! We discovered an unexpected role for the cytokine OSM in lung epithelial homeostasis and repair. 🧵 1/n www.science.org/doi/10.1126/...

Wonderful to catch up with two former @wcm-imp.bsky.social grad students at this @faseborg.bsky.social meeting! So proud of alum who are now faculty running their own labs- Priya Issuree (U Iowa) and Ruth Franklin @ruthfranklinlab.bsky.social (Harvard). Nothing makes a program director more happy!

We are so proud of Mergim for passing his quals! Definitely warrants lollipops advertising his favorite model antigen.

Congrats to IMP alum Virginia Pedicord on this wonderful distinction!!

🎓 Congrats to Dughan Ahimovic from the Josefowicz Lab on defending his thesis: "Deciphering the Histone Code for Immune Cell Development and Stimulation." His dedication and the lab’s collaborative spirit made this achievement possible! Congrats Dughan!👏🧬

🎓 Huge congratulations to Kathleen Mills from the @fungalspore.bsky.social Hohl Lab on successfully defending her thesis: "Epithelial-Immune Cell Crosstalk Orchestrates Pulmonary Immunity to Aspergillus fumigatus" Her strong, dedicated presence in the program will truly be missed! 💫🧬

🎓 Our next 2025 IMP PhD spotlight goes to Laura Menocal from the Schietinger Lab, she defended her thesis: Differentiation State Dynamics of Memory CD8 T Cells in Tumors. A true reflection of the lab’s close-knit and supportive environment, we're so proud of her hard work and growth over the years!

Huge congratulations to Joy Hsu from the @anandasabapathylab.bsky.social on defending her thesis: "Interrogating DC-Dependent Mechanisms Supporting Superior Immunity to Vaccinia Skin Scarification." Her research sheds light on how dendritic cells shape immune responses in skin-based vaccination!🧫🧬

🎓 We'd like to send another big congrats to our 2025 IMP PhD graduates! Our next few posts, we’ll be spotlighting recent thesis defenses and celebrating the labs that supported each journey. Stay tuned and help us cheer them on! 👏🔬🧬

Our paper is out! Kudos to 1st authors Mir Howlader, who received a @weillcornell.bsky.social Rachele Prize for this work, former Peds Rheum fellow William Ambler, and all co-authors! @jclinical-invest.bsky.social @wcm-imp.bsky.social @lupusresearch.bsky.social #lymphatic #stromal #photosensitivity

The 2025 Freeman Hrabowski Scholars | HHMI Freeman Hrabowski Scholars are outstanding early career faculty who have the potential to become leaders in their research fields.

Congratulations to IMP faculty member Chryssie Brown @chrysothemisbrown.bsky.social on becoming a Freeman Hrabowski Scholar, awarded by the HHMI @hhmi.org! Way to go Chryssie!!

Member Highlight: Meet Kathleen Mills - Biweekly newsletter of the International Cytokine & Interferon Society Meet Kathleen Mills, a PhD candidate at Weill Cornell doing my dissertation research in Tobias Hohl’s lab at Memorial Sloan Kettering Cancer Center. She's defending her dissertation soon and will star...

Get to know current IMP grad student Kathleen Mills through this interview. What fantastic advice for excelling in both science and life!

ILC3s sense gut microbiota through STING to initiate immune tolerance Maintaining immune tolerance to the microbiota is essential for gut health. Zhou et al. demonstrate that ILC3s are a RORγt+ APC that sense the microbiota through STING to induce microbiota-specific Tr...

Congratulations to the lab of IMP faculty member Greg Sonnenberg on this latest study showing STING in ILC3 can mediate immune tolerance, published this week in @cp-immunity.bsky.social

MSK Researchers Identify Key Player in Childhood Food Allergies: Thetis Cells Thetis cells, a class of immune cells first described by MSK researchers in 2022, play an essential and previously unknown role in suppressing inflammatory responses to food, a new study finds.

“This is a great example of how clinical studies can reveal clues to fundamental mechanisms in biology,” says MSK's @chrysothemisbrown.bsky.social ‬. "These new understandings can pave the way for new treatment strategies for food allergies, which are desperately needed.” Learn more ⬇️

Out today from The Perry Lab, our work suggesting how exposure to high fructose in pregnant mice or developing neonates directly affects neurodevelopment. In @natureportfolio.nature.com www.nature.com/articles/s41... @mskcancercenter.bsky.social @weillcornell.bsky.social.

Congratulations to our very own Inez Rogatsky for this incredible achievement! 🎉 @rogatskylab.bsky.social

Microbial cancer immunotherapy reprograms hematopoiesis to enhance myeloid-driven anti-tumor immunity Daman et al. show that bladder administration of BCG, a microbial immunotherapy for bladder cancer, triggers a systemic immune response, reprogramming HSPCs and resulting in increased myeloid-driven a...

So happy to finally get this story out there!

www.cell.com/cancer-cell/...

Congratulations to IMP faculty members Chryssie Brown @chrysothemisbrown.bsky.social and Alex Gitlin @gitlinlabmsk.bsky.social on receiving the 2025 Pershing Square Prize!! 🎉

Congratulations to our very own Dr. Marija Dacic!!!

Huge congrats to IMP students Andrew Daman (in Steve Josefowicz’s lab) and Anthony Antonelli (in Mike Glickman’s lab @michaelglickman.bsky.social) on their latest paper published in Cancer Cell @cp-cancercell.bsky.social

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity - Nature Communications Tissue-resident macrophages (TRM) are important mediators of local immunity. Here the authors show that the deficiency or inhibition of a kinase, WNK1, unlinks macrophage colony-stimulating factor sig...

Congrats to the lab of IMP faculty member @justinperryphd.bsky.social on this work showing how the kinase Wnk1 and transcription factor Irf8 mediate development of macrophages! Check it out in @natcomms.nature.com

Defining molecular circuits of CD8+ T cell responses in tissues during latent viral infection. A new study by Endi K. Santosa, Joseph C. Sun and colleagues @mskcancercenter.bsky.social rupress.org/jem/article/...

#InfectiousDisease #HostDefense #LymphocyteBiology