Ana Martínez del Val

📢 Registration is now open for the Annual Proteomics Gathering, taking place on 16th April in Madrid.

We look forward to welcoming you in Madrid!
REGISTRATION LINK: docs.google.com/forms/d/e/1F...

First real end-to-end protocol on Wall-E🤖

Huge thanks to #EyownTechnologies and #Opentrons for the support.

Goodbye manual pipetting😝😂

📣Today our colleague Samuel delivered an amazing seminar at the
@eubic-ms.org
Winter School 📣

He shared his single-cell analyses using a new workflow to study PTMs in DIA through open-search, called PTM-Beacon 💻🔍

Congrats!!

📢 Abstract Submission Now Open!

This is your chance to showcase your research at the 3rd Annual Proteomics Gathering in Madrid! 🇪🇸🧬

Submit your abstract easily via the QR code or the link below:
docs.google.com/forms/d/e/1F...

#APG2026 #YPIC #Proteomics #EarlyCareerResearchers #EuPA

We are very happy to have collaborated with María José Fernández-Gómez and Nerea Méndez-Barbero from Patologia Vascular lab in IIS-FJD

We’re proud to share that her poster was selected as the winner of the poster competition at #CNICPhDay!

Congratulations to the whole team for this achievement! 🎉💡

Do you have an exciting experiment that you'd love to do using proteomics in the context of your work? YPIC funds 5000 eur for your research idea to come to life!

⬇️⬇️⬇️⬇️⬇️

Sign up to our monthly newsletter and stay up to date with the latest developments of #TeamReSynBio mailchi.mp/resynbio/hup...
In this edition #PACREDOX by @anamdv.bsky.social at CNIC Spain. pubs.acs.org/doi/10.1021/...
Catch up with us @hupo-org.bsky.social 2025 in Toronto!

Thrilled to present my first work at CNIC published now at #AnalyticalChemistry @acs.org , showcasing a novel method to help streamline REDOX proteomics experiments by combining differential alkylation with PAC-based sample prep 🧲.
Check it out: pubs.acs.org/doi/full/10....

📣📣It is great to finally welcome @cnicproteomics.bsky.social to Bluesky 🎊 Follow them if you want to learn about the latest development in PTM research applied to cardiovascular diseases! 🫀🧪🧫🖥️🛠️

Today at CNIC we had the pleasure to host @clairekoenig.bsky.social for her talk about "Proteins for the past". It sparked a lot of interest!

El pasado viernes, 6 de junio, realizamos por primera vez el workshop "Enseña tu técnica", en el cual participaron cinco jóvenes investigadores, deleitándonos con interesantes e innovadoras técnicas que llevan a cabo en su trabajo diario.

No perdáis la oportunidad de registraros en la 1ª edición de “Enseña tú técnica”, en la cual, jóvenes investigadores con gran motivación, nos ilustrarán con diversidad de herramientas en las que están especializados. ¡Os esperamos!

📣 Thrilled to announce that my latest work during my postdoc at @jesperolsenlab.bsky.social is finally published!
Check out our quantitative proteomics analysis on a premetastatic colorectal cancer cohort, and how we identify potential biomarkers to assess risk relapse.

NextGen Proteomics Podcast · YPIC · Proteomics, self development, and much more!

Relocating for science? You're not alone! Join us in our new podcast episode sharing inspiring stories and diverse perspectives on moving and thriving in science. Let's learn from each other! open.spotify.com/show/7EmOcPU...

🌟 Happy Women and Girls in Science Day! 🌟

Science thrives on diversity and curiosity—let’s celebrate the brilliant minds shaping the future! 🔬🚀💡 #WomenInScience #February11 #Science

Protein aggregation capture assisted profiling of the thiol redox proteome Oxidative damage is critical in various diseases, including cardiovascular and neurological conditions. Thiol redox reactions, acting as oxidative stress sensors, influence protein structure and function. Redox proteomics based on differential alkylation of reduced and oxidized Cys forms using mass spectrometry enables comprehensive analysis of thiol redox status in cells and tissues. We introduce PACREDOX, an innovative redox proteomics approach based on the Protein Aggregation Capture (PAC) protocol and we demonstrate its compatibility with library free data-independent acquisition (DIA). PACREDOX reduces preparation time and costs compared to traditional methods, such as FASILOX, while maintaining thiol and proteome coverage. To enable library-free DIA, we corrected in silico spectral libraries in DIA-NN using experimental retention time data from beta-methylthiol-modified peptides. PACREDOX with DIA quantified 4,000 protein groups and ~45,000 modified peptides in myocardial tissue from a porcine model of atrial fibrillation, including over 8,000 cysteine-containing peptides, 30% of which were reversibly oxidized. Benchmarking PACREDOX and DIA against FASILOX in a myocardial infarction model reflects the potential and efficiency of this methodology to study oxidative damage. Overall, PACREDOX offers a high-throughput, cost-effective strategy for thiol redox proteome analysis, compatible with label-free quantitative workflows. ### Competing Interest Statement The authors have declared no competing interest.

📣📣First post for many things: 1st one in bluesky and 1st one of my work since joining CNIC!
Preprint for our novel implementation of PAC and DIA for REDOX proteomics, with application to cardiovascular diseases♥️🐖🔬. Check it out in @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

Yes, please, that one also seems an amazing group!

@clairekoenig.bsky.social and myself just joined, it would be great to join the pack as well 🐺