Shih-Chieh Lin

Inferring internal states across mice and monkeys using facial features - Nature Communications Here, the authors created a virtual reality task for monkeys and mice to explore if internal states like attention are similar across species. Their facial expressions during the task were similar, su...

Now out in @natcomms.nature.com‬: Mice and monkeys spontaneously shift through comparable cognitive states - and it's written all over their faces! (1/7)
www.nature.com/articles/s41...

A multidimensional distributional map of future reward in dopamine neurons - Nature An algorithm called time–magnitude reinforcement learning (TMRL) extends distributional reinforcement learning to take account of reward time and magnitude, and behavioural and neurophysiological...

Together with this paper by the group of Joe Paton www.nature.com/articles/s41... our results across the two papers complement each other providing strong evidence that distinct dopamine neurons discount future rewards at different rates providing a substrate for multi-timescale RL in the brain

Multi-timescale reinforcement learning in the brain - Nature Individual dopaminergic neurons encode future rewards over distinct temporal horizons.

Our work with Pablo Tano, @hyunggoo-kim.bsky.social Athar Malik, Alexandre Pouget and @naoshigeuchida.bsky.social exploring how dopamine neurons could enable multi-timescale reinforcement learning in the brain is out in @nature.com
www.nature.com/articles/s41...

Great work from my next door neighbor!

Imaging neuronal voltage beyond the scattering limit - Nature Methods ALI is an approach for analyzing voltage imaging data that is inspired by algorithms used in super-resolution microscopy. It allows resolving the activity of single neurons in densely labeled populati...

Big Congratulations Tsai-Wen!
www.nature.com/articles/s41...

Not sure about the question. Doesn’t hallucination, by definition, mean that the subject is unaware?
I am sure @kepecslab.bsky.social would have a better answer.

Striatal dopamine mediates hallucination-like perception in mice A mouse behavioral model of hallucinations yields circuit-level insights into the dopamine hypothesis of psychosis.

Something like this?

www.science.org/doi/abs/10.1...

Dopaminergic action prediction errors serve as a value-free teaching signal - Nature Dopaminergic action prediction error signals are used by mice as a value-free teaching signal to reinforce stable sound–action associations in the tail of the striatum.

Impressive study in @nature from my colleague Marcus Stephenson-Jones at UCL in the @sainsburywellcome.bsky.social

www.nature.com/articles/s41...

Individual variability of neural computations underlying flexible decisions - Nature Behavioural experiments to study decision-making in response to context-dependent accumulation of evidence provide testable models that are consistent with the heterogeneity in neural signatures among...

1/7 Our paper on individual variability in decision-making is finally out in @nature.com! Inspired by the classic work by Mante and Sussillo, we trained many rats to solve context-dependent decision-making, and we found that different brains use different neural mechanisms to solve the same task!

This looks awesome and very valuable for the study of basal forebrain. Anything in particular you are looking to characterize? We are very interested in GABAergic basal forebrain neurons and would love to know how rodent and human BF are conserved or differ.

Congrats to @kepecslab.bsky.social !

Beautiful work. Congratulations!

a picture of a pikachu with the words " i still have hope " written below it ALT: a picture of a pikachu with the words " i still have hope " written below it

Some glimmers of hope (but mostly confusion) this morning.

I have heard that no intramural tenure track investigators were supposed to be on the termination list although some folks clearly got termination notices.

I am actively checking into this every way I can.

1/2

This is atrocious!

A role for proprioceptors in sngception Proprioceptors mediate acidosis sensation that contributes to acid-induced pain chronicity.

Very interesting paper on a potential role for proprioceptors in sensing muscle acidosis and driving the perception of soreness.

"Sng" is a Taiwanese word for both sour taste and muscle soreness. It also imitates the natural vocalization of humans feeling sore.

www.science.org/doi/10.1126/...

Symmetries and Continuous Attractors in Disordered Neural Circuits A major challenge in neuroscience is reconciling idealized theoretical models with complex, heterogeneous experimental data. We address this challenge through the lens of continuous-attractor networks...

(1/30) New preprint! "Symmetries and continuous attractors in disordered neural circuits" with Larry Abbott and Haim Sompolinsky
bioRxiv: www.biorxiv.org/content/10.1...

Congratulations Dayu!

Prefrontal transthalamic uncertainty processing drives flexible switching - Nature By examining neural responses from tree shrews performing hierarchical decision tasks with rule reversals, the authors identify a thalamocortical mechanism for regulating cognitive flexibility.

Two papers out showing that thalamic inputs determine how cortex responds to a hierarchical task with rule switching:

www.nature.com/articles/s41...

journals.plos.org/plosbiology/...

🧠📈 🧪

The Transmitter books The Transmitter’s first book, “Thinking about neuroscience: Essays from the field,” features a rich collection of writing from researchers Nicole Rust, Anthony Zador and many more.

These essays offer the neuroscience community a place to explore the culture and practice of the field; to debate major questions; to examine the craft of neuroscience; and to trace its evolution over time. Download the book now: www.thetransmitter.org/transmitter-...

Deconstruction of a memory engram reveals distinct ensembles recruited at learning How are associative memories formed? Which cells represent a memory, and when are they engaged? By visualizing and tagging cells based on their calcium influx with unparalleled temporal precision, we ...

Our preprint of my PhD’s work in @gisellavetere.bsky.social lab is finally out on BiorXiv: doi.org/10.1101/2024..., and I’m so excited to share it! If you’ve ever wondered about reconciling engram manipulation experiments and neuronal activity during encoding, you’re on the right thread! 1/14

Neuroscience methods - YouTube Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!

Please like and repost to help us get the word out!

www.youtube.com/playlist?lis...

Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵

Really elegant work by @behrenstimb.bsky.social group. The idea of structured memory buffers provides a nice framework to understand 'goal-progress cells’ activity in the mPFC while mice learn a common task structure across many tasks. Not the easiest paper to read but really worthwhile!

Thrilled to present our latest BioRXiv on brain/body interactions during defensive freezing behaviour! (www.biorxiv.org/content/10.1...). You might think that a frozen animal has, well, frozen muscle activity, right? Wrong! Underneath the still surface of a fly, something in the legs is beating… 🧵

Thanks Kevin!

And thanks to my collaborators @alexkoulakov.bsky.social
Sergey Shuvaev and Divyansha Lachi !

(S & D -- have you joined the party here yet?)

Another huge influx of colleagues to BlueSky this week, so let me attach the fully updated Neurophysiology starter pack for anyone interested.

go.bsky.app/9FY1ReG

Great list with many familiar names. Can you add me to this list?

Happy Thanksgiving!

GitHub - AkariAsai/OpenScholar: This repository includes the official implementation of OpenScholar: Synthesizing Scientific Literature with Retrieval-augmented LMs. This repository includes the official implementation of OpenScholar: Synthesizing Scientific Literature with Retrieval-augmented LMs. - GitHub - AkariAsai/OpenScholar: This repository includes the...

OpenScholar: AI for scientific paper research
- Finds papers & summarizes content for user queries
- Trained on 45M+ Semantic Scholar papers
- 8B parameters
GitHub: github.com/AkariAsai/Op...

Just immigrated to Bsky. Really like the atmosphere and discussions here and reminded me of why I loved science twitter. Starter packs are very helpful and there are tools to convert starter packs into lists like this one:
nws-bot.us/bskyStarterP...

‘Huge influx’ of neuroscientists migrates to Bluesky Daily neuroscience-related posts on the social-media platform this week have increased more than 400 percent, on average, compared with October.

Huge influx of neuroscientists migrates to Bluesky
www.thetransmitter.org/community/hu...
#Neuroscience