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@sobolevsky.bsky.social

59 Followers  |  38 Following  |  4 Posts  |  Joined: 01.12.2024  |  1.5048

Latest posts by sobolevsky.bsky.social on Bluesky

Congratulations, Yifan, for the Anatrace Award! Yifan’s work on the TRPV1 structure with David Julius helped launch the Resolution Revolution in cryo-EM. Not just in membrane proteinsβ€”hardly any area of biophysics today has remained untouched by the techniques Yifan pioneered.

24.09.2025 22:09 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0

Congrats, Gabriela!

24.09.2025 23:06 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements Opening of the NMDA receptor involves bending of the helices lining the ion channel gate.

Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...

24.09.2025 18:39 β€” πŸ‘ 17    πŸ” 7    πŸ’¬ 5    πŸ“Œ 1
https://www.biorxiv.org/content/10.1101/2025.09.16.676506v1

How the twin-arginine translocase (Tat) system manages to transport folded proteins across membranes without any leaks? To answer this fundamental question we solved the first structure of TatB3C3 complex with bound cargo. Please check out new preprint!
t.co/962Kj9pt6F

18.09.2025 17:35 β€” πŸ‘ 55    πŸ” 18    πŸ’¬ 2    πŸ“Œ 1

Congrats, Ed!

16.09.2025 20:55 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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πŸš¨πŸ§ πŸ”¬ A major breakthrough in molecular neuroscience:

I am excited to share a new story from our lab, published in accelerated format today by @nature.com:

"Delta-type glutamate receptors are ligand-gated ion channels"

Read more here (free article link): rdcu.be/eGIKz

16.09.2025 16:47 β€” πŸ‘ 96    πŸ” 34    πŸ’¬ 10    πŸ“Œ 2
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GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins - Nature Structural & Molecular Biology Vega-GutiΓ©rrez et al. present cryo-electron microscopy structures of GluA4-containing AMPA receptors, which are key for brain signaling. They show GluA4-specific conformations and explain how subunit ...

www.nature.com/articles/s41...

15.09.2025 14:45 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 1
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Happy to share the molecular mechanism of activation of kainate-subtype ionotropic glutamate receptor GluK2 in complex with auxiliary subunits Neto2. In both closed/apo and open states, ligand-binding domain (LBD) layer has 2-fold rotational symmetry!
www.nature.com/articles/s41...

11.09.2025 13:17 β€” πŸ‘ 20    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Happy to share our new review on the structural pharmacology of TRP channels!
Check out the supplementary table, which includes a list of all ligands, corresponding PDBs of complexes with TRP channels, and reported affinity values.

www.sciencedirect.com/science/arti... #ionchannel #TRPchannel (1/5)

01.12.2024 03:00 β€” πŸ‘ 28    πŸ” 7    πŸ’¬ 1    πŸ“Œ 1

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