Respiratory viral infections awaken metastatic breast cancer cells in lungs Nature - Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by...

Paper rdcu.be/eyB5k shows how respiratory viruses including SARS‑CoV‑2 can awaken dormant breast cancer cells via IL‑6–driven inflammation and drive metastasis. Echoes our work rdcu.be/eyIFg COVID‑induced TGF‑β immunosuppression reactivates EBV in PASC, MIS-C

TGFβ links EBV to multisystem inflammatory syndrome in children Nature - Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

SARS-CoV-2 can disturb immune balance and awaken dormant guests like Epstein Barr Virus, a key oncogenic virus, via TGFβ driven suppression of T cell surveilance. Reactivation plays a role in MIS-C and other PASC. Our privious work @nature rdcu.be/eyIFg

“Plötzlich gab es zehnmal mehr Fälle.” Manche Kinder entwickeln nach einer leichten Corona-Infektion eine schwere Entzündungsreaktion: MIS-C, auch PIMS genannt. Lange Zeit war unklar, warum.

"Manche haben die Infektion nicht bemerkt. Wochen später haben die Kinder diese Entzündungsreaktion entwickelt. Auf den ersten Blick hat das mit SARS-2 nichts zu tun." @mashreghilab.bsky.social​ @drfzberlin.bsky.social​

The IL-22–oncostatin M axis promotes intestinal inflammation and tumorigenesis - Nature Immunology Hegazy and colleagues demonstrate that epithelial oncostatin M receptor expression drives gut inflammation and tumor formation.

#EveryCellIsAnImmuneCell! Cineus, Hegazy &co show @natimmunol.nature.com that during #colitis ILCs produce IL22 which drives oncostatin M #OSM signaling in intestinal #epithelial cells recruiting immune cells, exacerbating inflammation & being essential for tumorigenesis & colorectal tumor growth!

Symposium of EFIS on the occasion of 5 years of COVID-19 - 4 April 2025 - YouTube The Reaction to SARS-CoV-2: An Immunological Retrospective Symposium of EFIS on the occasion of 5 years of COVID-19 Kaiserin-Friedrich Stiftung, Robert-Koch ...

top-tier talks on immunology of COVID-19 at the symposium of the European Federation of Immunological Societies (EFIS) ...

m.youtube.com/playlist?lis...

The Immune Alliance Lecture Series We welcome you to the next Immune Alliance Seminar, this time with Keishi Fujio (Tokyo) and Ulf Panzer (Hamburg). The lecture takes place on march 19, 2025, 9am (in Germany)/5pm (in Japan), via zoom. Everyone is welcome to join. Registration is free.

We welcome you to the next Immune Alliance Seminar, this time with Keishi Fujio (Tokyo) and Ulf Panzer (Hamburg).

The lecture takes place on march 19, 2025, 9am (in Germany)/5pm (in Japan), via zoom. Everyone is welcome to join. Registration is free.

Register via www.dgfi.org/immune-alliance/

Join EFIS on 4 April for an encounter dedicated to exploring - from an immunological standpoint - the unresolved issues and misconceptions of COVID-19 vaccination five years after the WHO declaration of the pandemic.

Program:
www.efis.org/.../Reaction....

Register:
www.efis.org/events/efis-...

TGFβ links EBV to multisystem inflammatory syndrome in children - Nature Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

Nature research paper: TGFβ links EBV to multisystem inflammatory syndrome in children

https://go.nature.com/43HJ4pu

Rätsel um PIMS-Erkrankungen bei Kindern gelöst Berliner Forschende haben die Ursache für das rätselhaften Entzündungssyndrom gefunden.

Rätsel um PIMS-Erkrankungen bei Kindern gelöst #Corona #PIMS #Kindergesundheit

TGFβ links EBV to multisystem inflammatory syndrome in children - Nature Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.

How does SARS-CoV-2 lead to the multisystem inflammatory syndrome in children, a rare, potentially fatal condition?
www.nature.com/articles/s41...
High levels of TGFβ interfere with the child's response to control Epstein Barr virus, leading to its reactivation and severe inflammation @nature.com

Immune molecule links COVID‑19 with severe inflammatory disorder in children The molecule TGFβ suppresses the ability of T cells to protect against latent Epstein–Barr virus.

www.nature.com/articles/d41...

‼️ Cause of post-#COVID inflammatory shock in children identified: Reactivation of the Epstein-Barr virus appears to cause the rare condition #MISC. The findings, uncovered by a team from #CharitéBerlin & @drfzberlin.bsky.social, have now been published in @nature.com
www.charite.de/en/service/p...

EBV reactivation as a key mechanism of MIS-C after SARS-CoV-2 infection - DRFZ Why children become seriously ill weeks after a Covid-19 infection and how they can be cured Researchers from Dr. Mir-Farzin Mashreghi’s group from the German…

www.drfz.de/en/neuigkeit...

Our latest study in @nature.com reveals how #TGFβ drives Epstein-Barr Virus (#EBV) reactivation in multisystem inflammatory syndrome in #children (#MISC, #PIMS) following #COVID19.
@drfzberlin.bsky.social @mashreghilab.bsky.social

🔗 Read here:https://www.nature.com/articles/s41586-025-08697-6

Prof. Dr. Thomas Krieg is the new President of the Board of Trustees of the DRFZ, succeeding Prof. Dr. Elisabeth Märker-Hermann. Dr. med. Julia Rautenstrauch is elected Vice President of the Board of Trustees. www.drfz.de/en/neuigkeit...

#IUIS2025 is happening next year in Vienna, Austria, from August 17-22. Join us for a week of cutting-edge immunology, groundbreaking research, and global collaboration.
Early registration and abstract submissions are now OPEN at www.iuis2025.org! See you there! 🌍

Academic exchange between the University of Tottori in Japan and the DRFZ - contract recently signed: bit.ly/4aBmHmX

Dear friends of the DRFZ,

An eventful year is almost over.
We wish all colleagues and friends of the DRFZ a peaceful and relaxing holiday season.

We look forward to an exciting new year together in 2025!

Exploring transcription modalities from bimodal, single-cell RNA sequencing data Abstract. There is a growing interest in generating bimodal, single-cell RNA sequencing (RNA-seq) data for studying biological pathways. These data are pre

Bimodal single-cell RNA-seq data reveals four distinct modalities, uncovering genes tied to splicing, transcription & degradation rates.

academic.oup.com/nargab/artic...

ILC2 are a non-redundant source of IL-5 required for development and function of murine B1 cells
www.nature.com/articles/s41...

The Immune Alliance Meeting in Nara, Japan. Bridging great scientific exchange and collegial friendship across countries. @dgfi_org @YI_dgfi #immunology

Dear Immunology aficionados, you like to hear some exciting short lectures about the latest immunological discoveries from prominent scientists? Then join the virtual ImmuneAlliance Seminar series! Every 3rd Wed each month. For the link: dgfi.org/immune-allia.... #dgfi #ydgfi