RareCyte Inc.

Upcoming webinar on easy strategies for reliable spatial biomarker results, presented by Simon Goldstein (La Jolla Institute for Immunology).

Key topics:
✅ Validating antibody performance
✅ Designing and optimizing multiplex panels
✅ Sample preparation tips

Register ➡️ rarecyte.com/webinar-mast...

17-plex imaging of renal cell carcinoma, acquired on the Orion platform. 📸

This image, courtesy of Gaurav Shrestha, PhD from Ohio State University is featured in the RareCyte 2026 Calendar.

➡️ View all images from our Calendar Contest: rarecyte.com/2026calendar...

#RareCyteCalendar #MultiplexIF

Hear how spatial proteomics could change clinical practice in the near future.

Sandro Santagata (BWH) is presenting at #SABCS25 on how multiplex protein analysis enables deeper, more efficient tumor profiling, going beyond single-marker IHC.

Workshop details ➡️ sabcs.org/events/trans...

#AACR

We are looking forward to the PRIISM/IGI Retreat this week in NYC! 🌆

This year’s retreat will highlight breakthroughs in immunology and cutting-edge technologies, including the Orion platform.

#PRIISMIGI2025 #Immunology #SpatialBiology

@icahngenomics.bsky.social
@sinaiimmuno.bsky.social

Need more spatial context beyond single biomarker IHC?

Orion LE is your entry point into multiplex spatial biology by delivering high-plex immunofluorescence with a standard pathology workflow.

Learn more: rarecyte.com/orion-instru...

#Pathology #Immunofluorescence #SpatialBiology

Join our live session with Dr. Zhihong Chen, CTO, OCCAM Immune, Mount Sinai, for strategies for moving from high-plex spatial biology exploration to clinically actionable panels.

Save your seat: rarecyte.com/webinar-brid...

#SpatialBiology #Biomarkers #SpatialProteomics

Liquid Biopsy Services ➝ Rare Cell Analysis for Clinical Trials and Drug Development

Using the CyteFinder platform, we detect and quantify rare circulating cells at sensitivity levels 2–3 orders of magnitude beyond flow cytometry. 💡

Learn more: rarecyte.com/partnerships/

#LiquidBiopsy #RareCells

Confidence in every marker ✅ Orion provides flexible off-the-shelf panels and supports fully customizable panel development. This includes over 100 validated biomarkers, conjugation kits for custom markers, and dedicated expert support.

Learn more: rarecyte.com/orionpanels/

#SpatialBiology

Why is capturing 20 channels per round such a big deal for multiplex immunofluorescence? 🤔

Because instead of being limited to just a handful of biomarkers, the Orion platform delivers 20 channels per round (18 biomarkers + DNA + autofluorescence).

Learn more about Orion: rarecyte.com/orion/

Orion has arrived at The Ohio State University! Following a successful training at the Immune Monitoring and Discovery Platform (IMDP) last week, their team is ready to hit the ground running on spatial biology projects. Welcome to the RareCyte family!

#SpatialBiology #SpatialProteomics

Fast-track your spatial biology programs with our Precision Biology Services!

We support your research from custom assay development ➡️ clinical trial testing.

Ready to accelerate your spatial biology project? Let's connect: rarecyte.com/contact-us/

#SpatialBiology #OrionSpatial #ClinicalTrials

Say hello to Orion LE, the newest member of the Orion spatial biology family.

Orion LE is a multiplex immunofluorescence platform that makes spatial biology accessible for every lab.

Inquire to learn more: rarecyte.com/contact-us/?...

#OrionSpatial #SpatialBiology

Easily design a spatial biomarker panel using Orion validated antibody-conjugates. We take the time to validate our antibodies to ensure high-quality results and save you time. ✅

View our full validated biomarker list: bit.ly/3AyVNhF

#OrionSpatial #SpatialBiology

Back by popular demand…the RareCyte Calendar Image Contest! 📅 Submissions are now open to be featured in our 2026 calendar.

To enter, submit your most awe-inspiring image taken on either an Orion or CyteFinder instrument. Learn more about the contest: rarecyte.com/2026calendar/

#SpatialBiology

The Orion platform enables translational spatial biology by profiling 20 channels in a single round, delivering high-throughput spatial insights.

Explore this whole-slide pancreas ductal adenocarcinoma sample, taken on the Orion platform.

🔎 images.rarecyte.com/Q131-pancreas

#SpatialBiology

Live from Spatial Biology Congress in Guangzhou, China! 👋 Swing by RareCyte's booth to learn more about the Orion platform. Orion enables rapid, spatial protein profiling of 20 channels per round to power your tissue-based translational research.

#Congress2025 #SpatialBiology

Orion lets you profile 20 channels (17 biomarkers, 1 nuclear, 2 AF) in a single round, or cycle Orion to achieve a higher plex. This flexibility allows you to start broad (ex 51-plex in just 3 rounds), then focus on a clinically relevant panel for high-throughput validation – all on one platform.

Why is capturing 20 channels per round a game-changer for multiplex IF? 💭

With Orion, you can analyze far more biomarkers in a single scan than other multiplex IF platforms, which typically capture just 3-4 channels per round.

Learn more about Orion, rarecyte.com/orion/

#SpatialBiology

RareCyte is a proud sponsor of the 2025 Spatial Biology Congress, taking place in Guangzhou! 🌟

Stop by booth #2 to learn how to achieve high-throughput multiplex IF with single round imaging of up to 20 channels. Explore the Orion platform: rarecyte.com/orion/

@globalengage.bsky.social

What advancements have improved imaging tools for spatial proteomics?

✅ Increasing the # of protein biomarkers captured per round
✅ Staining your entire panel in a single round
✅ Maximizing sensitivity with narrow-band emission filters

Learn more: drugdiscoverynews.com/optimizing-s...

We’re thrilled to be part of the #SEASR meeting in Tampa, Florida! Swing by the RareCyte table and chat with Alicia Langeway who will introduce you to Orion: our single-round, high-plex, high-throughput multiplex immunofluorescence platform.

Learn more about Orion: rarecyte.com/orion/

💡 To deliver reliable, actionable data, spatial proteomics technologies must balance conflicting requirements: high-plex protein detection, high-resolution whole-slide imaging, and practical running costs and throughput.

Read full DNN article:
www.drugdiscoverynews.com/optimizing-s...

🔎 Dive into this interactive data set to explore the results of a whole slide colon adenocarcinoma experiment. Take a tour of the tissue microenvironment and toggle between 13 different markers at your own pace.
➡ images.rarecyte.com/Q135-colon

#ColonCancer #SpatialBiology #OrionSpatial

Always great to bring the RareCyte team together! We’re here to help push your research forward with innovative technologies and dedicated support - every step of the way. Here’s to continuing to advance research together!

#Biotech #CompanyCulture

Live from #CYTO2025! Connect with the RareCyte team at Booth #827 to explore adding spatial context to your cytometry research using the Orion platform.

#CYTO #SpatialBiology #SpatialProteomics #OrionSpatial

Spatial biology 🤝 flow cytometry at #CYTO2025! Stop by RareCyte Booth #827 to explore adding spatial context to your cytometry research using the Orion platform.

Book a meeting with RareCyte at CYTO here, calendly.com/rarecyte-sal...

#CYTO #SpatialBiology #Cytometry #OrionSpatial

RareCyte in collaboration with UCSF developed a novel, highly sensitive assay to detect and characterize CTCs in the cerebrospinal fluid of patients with leptomeningeal disease. Shout out to Laura Huppert who gave an excellent presentation on this work at #AACR2025!

aacrjournals.org/cancerres/ar...

To identify therapy resistant cell populations in PDAC, Dr. Yana Zavros compared surgically resected tissue specimens to the metastatic tumor tissue by spatial transcriptomics and multiplex IF.

Watch full webinar on-demand: rarecyte.com/exploring-ne...

#PancreaticCancer #SpatialBiology

Let’s connect at #CYTO2025! Catch RareCyte at Booth #827 to explore adding spatial context to your cytometry research using the Orion platform.

📆 Book a meeting with RareCyte at CYTO: calendly.com/rarecyte-sal...

#SpatialBiology #SpatialProteomics #Cytometry #RareCyte

Macrophages restrict tumor permissiveness to immune infiltration by controlling local collagen topography through a Tcf4-Collagen3 fibrotic axis During tumorigenesis, the extracellular matrix (ECM), which constitutes the structural scaffold of tissues, is profoundly remodeled. While the impact of such remodeling on tumor growth and invasion ha...

#FridayRead: New research reveals how macrophages shape the TME by altering collagen structures, directly impacting immune cell infiltration into tumors.
The Orion platform was used for 16-plex spatial protein profiling of T cell clusters.

DOI: doi.org/10.1101/2025...

#SpatialBiology