Nature Reviews Immunology

Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...

NEW Review from @soreklab.bsky.social @dinahoch.bsky.social explains how immune pathways manipulate the availability of nucleotides, chemically modify nucleotides to generate immune signalling molecules, and produce altered nucleotides that poison viral replication
#immunosky #microsky #phagesky

Congrats to Adam Grippin, a resident in the radiation oncology program @mdanderson.bsky.social , and soon to be physician scientist, on his latest commentary in @natrevimmunol.nature.com, highlighting a new cell surface mapping technique with implication in understanding immune cell functions.

Connection and communication between the nervous and immune systems - Nature Reviews Immunology Here, Swirski and colleagues explore how the nervous and immune systems connect and collaborate to respond to internal and external stimuli. In particular, they consider how the exchange of informatio...

Very happy to share this Perspective in @natrevimmunol.nature.com

www.nature.com/articles/s41...

Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia Bone marrow is both a primary site for blood cell production and a fertile niche for metastatic cancer cell growth, notably in breast cancer. Although anemia is common among patients with bone metasta...

Original preprint here
www.biorxiv.org/content/10.1...

Further discussion from @preprintclub.bsky.social here
www.preprintclub.com/preprint-rev...

Another Journal Club article from @preprintclub.bsky.social -
Mehdi Chaib and James Allison @mdanderson.bsky.social report on @biorxiv-immuno.bsky.social preprint by Han et al. that describes a mechanism by which metastatic tumours secure iron in the bone marrow
#immunosky #cancersky
rdcu.be/euBTD

More discussion from @preprintclub.bsky.social here:
www.preprintclub.com/preprint-rev...

A microenvironment-driven, HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes The evolving antigenic landscape of autoimmune diabetes reflects a dynamic failure to preserve self-tolerance. Yet, how novel neoantigens emerge in humans remains incompletely understood. Here, we des...

Original preprint here: www.biorxiv.org/content/10.1...

NEW Journal Club article from @boyantsankovsci.bsky.social & Dana Philpott @preprintclub.bsky.social highlights a @biorxiv-immuno.bsky.social paper by Srivastava et al. that identifies a previously unknown C19S-modified insulin neoantigen.
rdcu.be/et76Z

Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry - Nature Reviews Immunology White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads to neuropathology.

Highlight of a study by Teruyuki Sano and team in @nature.com revealing potential mechanisms by which commensal-specific T cells can contribute to extraintestinal inflammation
#immunosky #microsky #neurosky

Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design - Nature Reviews Immunology T cells have an essential role in immune responses to Mycobacterium tuberculosis, but the mechanisms by which they may provide protective immunity remain poorly understood. This Review explores the kn...

Thrilled to have co-authored this review with amazing colleagues! We dive into the mysteries of T cell immunity in TB and explore how cutting-edge tech could unlock better vaccines.
#Tuberculosis #Immunology #TCells #Vaccines
@natrevimmunol.nature.com

www.nature.com/articles/s41...

It is truly an honor that my article has been chosen for the @natrevimmunol.nature.com journal club ! @aphp.bsky.social @hopitalrobertdebre.bsky.social

Innate immune responses to pathogens at the maternal–fetal interface - Nature Reviews Immunology During pregnancy, innate immune mechanisms at the maternal–fetal interface are important for protecting the developing fetus from pathogens. However, excessive immune activation can be harmful to the ...

Review @natrevimmunol.nature.com @yaelalippe.bsky.social @msdiamondlab.bsky.social
Innate immune responses to pathogens at the maternal–fetal interface
www.nature.com/articles/s41...

Please consider applying for the Young Investigator Award @emds2025.bsky.social Full details at www.emds2025.com

@britsocimm.bsky.social @edinuni-irr.bsky.social @uofgsii.bsky.social @natrevimmunol.nature.com

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

Thrilled to see our review out in @natrevimmunol.nature.com together with my amazing mentors @jfcryan.bsky.social and Ger Clarke. @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social @uccresearch.bsky.social

www.nature.com/articles/s41...

A role for microglia in mediating the microbiota–gut–brain axis - Nature Reviews Immunology This Perspective explores how the gut microbiota influences the function and heterogeneity of microglia, highlighting their roles in neurological and neuropsychiatric disorders, and discusses the ther...

A Perspective article by @lilykeane.bsky.social, Gerard Clarke & @jfcryan.bsky.social @apcmicrobiomeirel.bsky.social proposes that microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric disease
#immunosky #microsky #microbiome

Vaccines are rigorously tested, they are effective, and they save lives. More than 150 million lives have been saved in the past 50 years thanks to vaccines!

But you may be worried about what's in them?
So, let’s break it down ⬇

Maternal immune activation imprints a regulatory T cell deficiency in offspring that drives an autism-like phenotype Maternal immune activation (MIA) triggers an IL-17-driven autism spectrum disorder (ASD) in mouse and human offspring. While regulatory T cells (Tregs) regulate Th17 cells, their involvement in MIA an...

Original preprint here: www.biorxiv.org/content/10.1...

2025-apr-ellul

Further discussion from @preprintclub.bsky.social here:
www.preprintclub.com/preprint-rev...

NEW Journal Club article from @preprintclub.bsky.social discusses @biorxiv-immuno.bsky.social preprint by Ellul et al. showing that maternal immune activation in mice drives regulatory T cell dysfunction in offspring and autism-like behaviours
rdcu.be/eo65K

And another paper from @kedmiranit.bsky.social, published in @nature.com, after this Highlight was written, adds to the story

www.nature.com/articles/s41...

From the labs of Dan Littman in @nature.com, @chrysothemisbrown.bsky.social in @science.org, Marco Colonna in @cp-cell.bsky.social, @danmucida.bsky.social in @science.org, and James Gardner in @jem.org

RORγt+ antigen-presenting cells mediate food tolerance - Nature Reviews Immunology Five recent papers identify the RORγt+ antigen-presenting cells that induce food-antigen-specific regulatory T cells and establish food tolerance.

Not one, not two .... but FIVE recent papers highlighting a role for RORgt+ antigen-presenting cells in the gut in establishing tolerance to food antigens
#oraltolerance #immunosky #foodallergy

Can we improve immune health by restoring microbial biodiversity? - Nature Reviews Immunology Diverse microbial exposures in early life reduce the risk of inflammatory conditions, including allergies and autoimmunity. Emerging data suggest that microbial diversity is as important as microbial ...

A way to improve a person's immune system response is through the diversity of their microbiome
www.nature.com/articles/s41...

2025-apr-raposo

Further discussion from @preprintclub.bsky.social here: www.preprintclub.com/preprint-rev...

Functional memory T cells are derived from exhausted clones and expanded by checkpoint blockade Immune checkpoint blockade can facilitate tumor clearance by T cells, resulting in long term patient survival. However, the capacity of exhausted CD8+ T cells (Tex), present during chronic antigen exp...

Original preprint here: www.biorxiv.org/content/10.1...

NEW Preprint Watch from Annette Wu & @wenjiang-nano.bsky.social @preprintclub.bsky.social reporting on @biorxiv-immuno.bsky.social preprint by @colinraposo.bsky.social et al. showing that checkpoint blockade drives expansion of exhausted T cell clones that develop functional memory
rdcu.be/ek1kY

Last chance to submit late-breaking abstracts for IUIS 2025!

Highly recommend!

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...