Klein and Overholtzer @mskcancercenter.bsky.social discuss new findings from the Deretic group (@thabataduque.bsky.social et al. rupress.org/jcb/article/...) showing ATG16L, a regulator of lysosomal stress responses, has a day job regulating the v-ATPase. rupress.org/jcb/article/...

Really happy with this spotlight about our recent publication! Check also this spotlight on @jcb.org

ATG16L1 controls mammalian vacuolar proton ATPase Duque et al. report a hitherto unappreciated function of ATG16L1, best known for its roles in canonical autophagy and membrane atg8ylation, in directly reg

Prior studies show that #Lysosome proton pump V-ATPase interacts with #ATG16L1, an #autophagy factor, to direct membrane #atg8ylation upon damage. A new study shows the reverse - ATG16L1 inhibits V-ATPase.

ATG16L1 controls mammalian vacuolar proton ATPase url: rupress.org/jcb/article-...

Everyone interested in #autophagy knows that #ATG16L1 is an E3 ligase for membrane #atg8ylation sometimes directed by V-ATPase. A new study shows the reverse - that ATG16L1 inhibits V-ATPase.
ATG16L1 controls mammalian vacuolar proton ATPase rupress-org.libproxy.unm.edu/jcb/article-ab…