Richard Eva Lab

A huge thank you to the Eva and Bradbury Lab members, @wolfsonsparc.bsky.social, and all the GRC CNS Injury and Repair attendees. So much fun, so much science and all top quality. A poster prize for Zahra to top it off! New ideas, collaborations, connections. As a great conference should be!

Love this. Who needs sheets!?

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region - Acta Neuropathologica Immunotherapies targeting extracellular tau share the premise that interrupting cell-to-cell spread of tau pathology in Alzheimer’s disease (AD) will slow dementia pathogenesis. Whether these interven...

*New paper alert* - extracellular tau blocks synaptic plasticity in vivo via its microtubule-binding domain, which can be rescued by our Gen2 tau antibodies - all the product of a great collaboration with Michael Rowan and colleagues at @tcddublin.bsky.social link.springer.com/article/10.1...

What an interesting paper, such a huge amount of work! Great to see it cover the different CNS and PNS axon types.

And thank you for the thread: enjoyed following the story, showing how many people were involved, how long it took, and how it all came together. A phenomenal community effort!

Regenerating Retinal Neurons using AAV Vectors / ISCRM .

Researchers in the Reh Lab have produced the clearest evidence yet that AAV-delivered genes can stimulate regeneration in the mammalian retina. @tomreh.bsky.social Marina Pavlou. #retina #regeneration @uwmedicine.bsky.social

shorturl.at/qVUKz

Our paper is finally out!

Neuronal autophagy controls excitability via ryanodine receptor-mediated regulation of calcium-activated potassium channel function.
www.pnas.org/doi/abs/10.1...

Very cool! Some axonal GAPDH mRNA? Mature neurons?

A fantastic place to work with brilliant colleagues in a vibrant part of London!
Wolfson SPaRC is hiring for Lecturer and above-level roles. Come and be part of the exciting work happening here. Amazing people, meaningful impact, and a location that’s hard to beat.

Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration - Nature Communications Therapeutic interventions for motor axon regeneration following peripheral nerve injury are currently unavailable. Here authors show local administration of a non-muscle myosin II inhibitor at the inj...

Excellent story from the Woolf lab!
www.nature.com/articles/s41...

Combinatorial approaches increasing neuronal activity accelerate recovery after spinal cord injury Chen et al. report that patients with spinal cord injury who received treatment with a combination of Hebbian stimulation to strengthen corticospinal synap

Significant functional improvements in walking speed/endurance for people with spinal cord injury with combined 4-aminopyridine and paired associative stimulation.

A great study by Dr. Monica Perez and an All Star group.

#SCIrehab 🧪 #phySKYatry

academic.oup.com/brain/advanc...

Biphasic inflammation control by dedifferentiated fibroblasts enables axon regeneration after spinal cord injury in zebrafish Fibrosis and persistent inflammation are interconnected processes that inhibit axon regeneration in the mammalian central nervous system (CNS). In zebrafish, by contrast, fibroblast-derived extracellu...

Excited to share the latest work from our lab: www.biorxiv.org/content/10.1...

That's definitely a smile.

Some interesting findings for ribosomal populations in mature human neurons...

Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration | PNAS Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneous...

Our CNS regeneration work has now been published in @PNAS. It was a huge undertaking in collaboration with @Twiss @Benowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin
@ArthurEnglish @JohnHolule labs. Thank you all, and @MerkinPnnrCtr, for funding.

www.pnas.org/doi/10.1073/...

Ooh, that's very interesting...

Thank you!

Very helpful , thank you! Room for an axon protection and regeneration lab!?

An exciting paper demonstrating a complex integrin trafficking mechanism with potential implications for the machinery regulating axon growth and regeneration. Intriguing!

FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation Glycolysis and the TCA cycle are reprogrammed in cancer cells to meet bioenergetic and biosynthetic demands, including by engagement with the extracellular matrix (ECM). We show that focal adhesion ki...

Masalmeh, RHA, et al. FAK modulates glioblastoma stem cell energetics via regulation of glycolysis and glutamine oxidation. bioRxiv posted 20 February 2025 doi:10.1101/2024.12.11.627900. www.biorxiv.org/content/10.1...

Genetically encoded biosensor for fluorescence lifetime imaging of PTEN dynamics in the intact brain - Nature Methods A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...

I started my lab more then 4 years ago, and we have endured some very challenging times ever since.…I am very excited to share the first paper from my lab, published now in @naturemethods.bsky.social
www.nature.com/articles/s41...

Gif showing a spine containing spine apparatus, reconstructed from FIB-SEM images. ER: red, synapse: yellow, plasma membrane: blue

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...

ICYMI our latest paper is now out officially in print (is there still such thing?). And since Dev Cell @cellpress.bsky.social did not select our submission for cover, I post it here. A really cool illustration from my son Zack. www.cell.com/developmenta...

Aged motor neurons display an impaired response to muscle BDNF, consistent with downregulation of TrkB at the neuromuscular junction.

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation Ribosomes cooperate through transient collisions to ensure efficient translation.

Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex...

Oh, that’s a really tough one. Honestly, I think we need way more funding for pet longevity research—clearly, science is slacking.

An interdisciplinary perspective on peripheral drivers of pain in rheumatoid arthritis - Nature Reviews Rheumatology Emerging data suggest that resident cells and locally produced mediators interact with nerves in the joint to promote pain in rheumatoid arthritis. This Review discusses the potential neuro–immune–stromal interactions promoting joint pain and highlights the need for an interdisciplinary approach to therapeutic development.

Welcome to Bluesky @taamslab.bsky.social! Everyone - follow them for amazing #ImmunoSky #neuroimmune 🧪 🧠 content on #Arthritis, #Tcells and many other things. And of course, don't forget to read our latest review: www.nature.com/articles/s41...

I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.

OXR1 maintains the retromer to delay brain aging under dietary restriction - Nature Communications Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by m...

Since I've met many new people on @bsky.app, I wanted to re-share this paper we published earlier this year in @naturecomms.bsky.social! We found OXR1, which regulates #longevity and #brainaging through neuronal endocytic recycling. Read below for a summary 👇
www.nature.com/articles/s41...
#GeroSky

Finally my first author preprint at Cullen's lab is out! Amazing collaboration with Kevin and @brettcollins.bsky.social where, by using dedicated proximity proteomics, Biochemistry, crystallography and structural prediction, we show new aspects of human Retromer complex acting as hub for RAB GTPases

Celebrating this fantastic work lead by Kristýna Kárová (with some EvaLab contribution!), its new home in Molecular Therapy. Spinal cord axon regeneration with improvements in paw reaching, grip strength, and ladder walking using a gene therapy approach. Delta is the way! tinyurl.com/55en9z6d