Rik van der Kant

Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation Mutations in microtubule-associated protein Tau (MAPT), the gene that codes for the protein Tau, cause frontotemporal lobar degeneration (FTLD) with phenotypes ranging from behavioral changes to cogni...

Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation #JLipidRes #MassSpec www.jlr.org/article/S002...

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases - Nature Metabolism The authors introduce the Neurolipid Atlas, a dynamic resource for the community to gain insight into lipid alterations in neurodegenerative disease, and they leverage the platform to show how cholesterol alterations in astrocytes can dysregulate neuroinflammatory pathways in Alzheimer disease.

RESEARCH | M Giera, @rikvanderkant.bsky.social et al (LUMC, VU; NL)

Neurolipid Atlas- lipidomic insights into neurodegenerative diseases e.g. cholesterol's role in Alzheimer’s disease 🧪

𝗡𝗲𝘄: 𝗧𝗵𝗲 𝗡𝗲𝘂𝗿𝗼𝗹𝗶𝗽𝗶𝗱 𝗔𝘁𝗹𝗮𝘀 (𝗡𝗟𝗔) - 𝗮 𝗹𝗶𝗽𝗶𝗱𝗼𝗺𝗶𝗰𝘀 𝗿𝗲𝘀𝗼𝘂𝗿𝗰𝗲 𝗳𝗼𝗿 𝗻𝗲𝘂𝗿𝗼𝗱𝗲𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀! @rikvanderkant.bsky.social @vuamsterdam.bsky.social @alzheimerams.bsky.social www.amsterdamumc.org/en/research/...

New research presents a data common named the "Neurolipid Atlas" - a useful resource prepopulated with isogenic iPS cell-derived lipidomics data for different brain conditions ( #Alzheimers, #Parkinsons, #ALS, #FTD)
www.nature.com/articles/s42...

Our main conclusions:

➡️ Lipids are changes in multiple brain diseases
➡️ In Alzheimer and ApoE4 astrocytes triglycerides and cholesteryl esters accumulate

And, most surprising:
➡️ Altered cholesterol storage in ApoE4 astrocytes suppresses their HLA-immune function

Proud to present our new paper in @natmetabolism.nature.com

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY

Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).

APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamics The lipids and proteins that comprise lipid droplets regulate several cellular functions including lipid storage, stress responses, and inflammation. Glial lipid droplets have been implicated in the p...

🧪New preprint🔬🧫

Not all lipid droplets are created equal! 💥

APOE shapes the LD proteome & lipidome in astrocytes; it’s the dynamics that distinguish E2 protection from E4 risk.

Led by Carla Cuni-Lopez w/ CARD proteomics, Giera lab & @rikvanderkant.bsky.social

📄 www.biorxiv.org/content/10.1...

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…

Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.

Read here www.sciencedirect.com/science/arti...

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Grateful for the opportunity to co-chair and present at #ADPD2025.Thanks to my co-chair Ole Isacson &other session speakers Thomas Sudhof,Silke Nuber,Alexander Ehrenberg @garyholab.bsky.social @rikvanderkant.bsky.social Tim Bartels. Wonderful to see progress on lipid metabolism research in AD & PD.

Lets talk oxysterols!

Anyone going to #adpd and wants to hang out?

Here's our incredible FULL LINEUP of speakers for #SCMND2025!

Abstract submission closes Friday!
scmnd.com

@rikvanderkant.bsky.social @selinawray.bsky.social @carlescalatayud.bsky.social @rcasterton.bsky.social @annawilliamslab.bsky.social @sergiuppasca.bsky.social @neuralstemcells.bsky.social

Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion Mitochondrial respiratory complex III sustains IL-10 production in macrophages and promotes tumor-mediated immune evasion.

Fresh off the press! 🥳 Congrats to @alessiazotta.bsky.social @lukeanthonyoneill.bsky.social and team for this awesome paper, about mitochondrial complex III driving IL-10 production by macrophages. Thanks for having me and my Austrian colleagues as a part of this! ☺️

www.science.org/doi/10.1126/...

Mitochondrial fatty acid oxidation regulates monocytic type I interferon signaling via histone acetylation Mitochondrial fatty acid oxidation is essential for the epigenetic control of type I interferon signaling.

Mitochondrial fatty acid oxidation regulates monocytic type I interferon signaling via histone acetylation

www.science.org/doi/10.1126/...

A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
www.cell.com/neuron/fullt...

new preprint!

www.biorxiv.org/content/10.1...

a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)

first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

Cheering for team Morganti here

Scientific Conferences Find upcoming Alzheimer's Association conferences. Attend virtually or in person to learn and network with the dementia research community.

Abstract submissions for #AAICAdvancements: APOE & Lipid Biology, and #Tau2025 close Dec. 6 for ISTAART members!

Share your work on APOE’s role in neurodegeneration or tauopathies like PSP, CBD & FTD. Don’t miss out on these two meetings—Submit now!

www.alz.org/research/for...

Abstract submission for Stem Cell Models of Neurodegeneration 2025 is open until January 31st 2025! Come register and share your work with us!

scmnd.com

We look forward to hosting you in Edinburgh next year :-)

#neuroscience #iPSC #neurodegeneration #stemcells #dementia #organoids

APOE ε4–associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuum INTRODUCTION While the role of apolipoprotein E (APOE) ε4 in Alzheimer's disease (AD) susceptibility has been studied extensively, much less is known about the differences in disease presentation in...

Happy to share a new paper from the lab, published in Alzheimer’s & Dementia: APOE4-associated heterogeneity in neuroimaging biomarkers across the Alzheimer’s disease continuum alz-journals.onlinelibrary.wiley.com/doi/full/10.... 1/7

Since everyone else is doing it… Here’s a starter pack for researchers studying the most interesting allele in AD. go.bsky.app/PDtaUP6 Let me know if you want to be added (doesn’t have to be the sole focus of your research). Also, it turns out a lot of my favorite APOE4 folks aren’t on bluesky yet.

I also made a starters pack for all Riks working on Tau.

Are you a Rik that works on Tau? Comment below and I will add you.

bsky.app/profile/did:...

This spring, we reported in Nature a therapeutic approach for Timothy syndrome

This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease

Happy Sinterklaas for all Dutchies!
We had a thematic journal club this week!

Link to the program:

www.alz.org/media/Docume...

And registration/abstract submission

www.alz.org/apoe/overvie...

For my first post, an invitation to join us in Miami! A lot of thing on ApoE and lipids are moving fast, catch up!

Abstract submission is now open!

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia | EMBO Molecular Medicine imageimageIn the early phase of Alzheimer’s disease, astrocytes are the primary source of APOE in the brain. This study examined the effects of astrocyte-derived human APOE isoforms in APOE-deficient ...

APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia

#gliasky

go.bsky.app/Lyzro3M

!WELCOME!

thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.

apologies for missing many of you - please do reply to get added

and remember to repost so the newbies can find us!