Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation #JLipidRes #MassSpec www.jlr.org/article/S002...
RESEARCH | M Giera, @rikvanderkant.bsky.social et al (LUMC, VU; NL)
Neurolipid Atlas- lipidomic insights into neurodegenerative diseases e.g. cholesterol's role in Alzheimer’s disease 🧪
𝗡𝗲𝘄: 𝗧𝗵𝗲 𝗡𝗲𝘂𝗿𝗼𝗹𝗶𝗽𝗶𝗱 𝗔𝘁𝗹𝗮𝘀 (𝗡𝗟𝗔) - 𝗮 𝗹𝗶𝗽𝗶𝗱𝗼𝗺𝗶𝗰𝘀 𝗿𝗲𝘀𝗼𝘂𝗿𝗰𝗲 𝗳𝗼𝗿 𝗻𝗲𝘂𝗿𝗼𝗱𝗲𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗱𝗶𝘀𝗲𝗮𝘀𝗲𝘀! @rikvanderkant.bsky.social @vuamsterdam.bsky.social @alzheimerams.bsky.social www.amsterdamumc.org/en/research/...
New research presents a data common named the "Neurolipid Atlas" - a useful resource prepopulated with isogenic iPS cell-derived lipidomics data for different brain conditions ( #Alzheimers, #Parkinsons, #ALS, #FTD)
www.nature.com/articles/s42...
Our main conclusions:
➡️ Lipids are changes in multiple brain diseases
➡️ In Alzheimer and ApoE4 astrocytes triglycerides and cholesteryl esters accumulate
And, most surprising:
➡️ Altered cholesterol storage in ApoE4 astrocytes suppresses their HLA-immune function
Proud to present our new paper in @natmetabolism.nature.com
The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
lnkd.in/eVzFrmUY
Check out our open-access platform chock-full with iPSC- and 🧠 lipidomics data (www.neurolipidatlas.com).
🧪New preprint🔬🧫
Not all lipid droplets are created equal! 💥
APOE shapes the LD proteome & lipidome in astrocytes; it’s the dynamics that distinguish E2 protection from E4 risk.
Led by Carla Cuni-Lopez w/ CARD proteomics, Giera lab & @rikvanderkant.bsky.social
📄 www.biorxiv.org/content/10.1...
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.
@jonykipnis.bsky.social
www.nature.com/articles/s41...
Grateful for the opportunity to co-chair and present at #ADPD2025.Thanks to my co-chair Ole Isacson &other session speakers Thomas Sudhof,Silke Nuber,Alexander Ehrenberg @garyholab.bsky.social @rikvanderkant.bsky.social Tim Bartels. Wonderful to see progress on lipid metabolism research in AD & PD.
Lets talk oxysterols!
Anyone going to #adpd and wants to hang out?
Here's our incredible FULL LINEUP of speakers for #SCMND2025!
Abstract submission closes Friday!
scmnd.com
@rikvanderkant.bsky.social @selinawray.bsky.social @carlescalatayud.bsky.social @rcasterton.bsky.social @annawilliamslab.bsky.social @sergiuppasca.bsky.social @neuralstemcells.bsky.social
Fresh off the press! 🥳 Congrats to @alessiazotta.bsky.social @lukeanthonyoneill.bsky.social and team for this awesome paper, about mitochondrial complex III driving IL-10 production by macrophages. Thanks for having me and my Austrian colleagues as a part of this! ☺️
www.science.org/doi/10.1126/...
Mitochondrial fatty acid oxidation regulates monocytic type I interferon signaling via histone acetylation
www.science.org/doi/10.1126/...
A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
www.cell.com/neuron/fullt...
new preprint!
www.biorxiv.org/content/10.1...
a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)
first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
Cheering for team Morganti here
Abstract submissions for #AAICAdvancements: APOE & Lipid Biology, and #Tau2025 close Dec. 6 for ISTAART members!
Share your work on APOE’s role in neurodegeneration or tauopathies like PSP, CBD & FTD. Don’t miss out on these two meetings—Submit now!
www.alz.org/research/for...
Abstract submission for Stem Cell Models of Neurodegeneration 2025 is open until January 31st 2025! Come register and share your work with us!
scmnd.com
We look forward to hosting you in Edinburgh next year :-)
#neuroscience #iPSC #neurodegeneration #stemcells #dementia #organoids
Happy to share a new paper from the lab, published in Alzheimer’s & Dementia: APOE4-associated heterogeneity in neuroimaging biomarkers across the Alzheimer’s disease continuum alz-journals.onlinelibrary.wiley.com/doi/full/10.... 1/7
Since everyone else is doing it… Here’s a starter pack for researchers studying the most interesting allele in AD. go.bsky.app/PDtaUP6 Let me know if you want to be added (doesn’t have to be the sole focus of your research). Also, it turns out a lot of my favorite APOE4 folks aren’t on bluesky yet.
I also made a starters pack for all Riks working on Tau.
Are you a Rik that works on Tau? Comment below and I will add you.
bsky.app/profile/did:...
This spring, we reported in Nature a therapeutic approach for Timothy syndrome
This has been a long journey starting with making hiPS cell-derived neurons in 2D cultured 15 years ago when I was a postdoc & continued with creating in the lab #organoid and then #assembloid models of this disease
Happy Sinterklaas for all Dutchies!
We had a thematic journal club this week!
Link to the program:
www.alz.org/media/Docume...
And registration/abstract submission
www.alz.org/apoe/overvie...
For my first post, an invitation to join us in Miami! A lot of thing on ApoE and lipids are moving fast, catch up!
Abstract submission is now open!
APOE from astrocytes restores Alzheimer’s Aβ-pathology and DAM-like responses in APOE deficient microglia
#gliasky
go.bsky.app/Lyzro3M
!WELCOME!
thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.
apologies for missing many of you - please do reply to get added
and remember to repost so the newbies can find us!
