Sarada Ketharnathan

Sarada Ketharnathan

@saradakethar.bsky.social

Research Associate in the Berman lab, studying childhood leukemia and leukemia predisposition using zebrafish

66 Followers 51 Following 25 Posts Joined Nov 2024
2 months ago
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Stress-induced loss of CTCF reveals an alternative, promoter-based mode of cohesin looping Cells continually encounter environmental stressors that challenge homeostasis. How three-dimensional (3D) chromatin structure contributes to these stress responses, particularly under hyperosmotic co...

Excited to finally share what I’ve been working on during my PhD 😊 Best holiday gift EVER!

We just posted a new preprint from the @dphansti.bsky.social 👇

Preprint: www.biorxiv.org/content/10.6...

🧵

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3 months ago
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Thrilled to be presenting at the 10th anniversary of the ASH Scientific Workshop on Germline Predisposition to Hematological Malignancies and Bone Marrow Failure. Tune into the live stream today from 2-5 pm ET #ASH25 #BMF-GPD

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3 months ago
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The future of hematological genomics is here. The ASH HematOmics Program (ASHOP) developed with St. Jude & the Munich Leukemia Laboratory offers free access to powerful genomic visualization tools for blood disease research.
🔗 https://ow.ly/G7Ol50XukwQ
#Genomics #HemeSky #MedSky

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4 months ago

For those interested:

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5 months ago
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#ZDM18 has kicked off! We are excited to have Shiaulou Yuan talk about “Joining forces: cilia and Pkd1l1 as mechanotransducers that shape cardiac left-right asymmetry.” #zdmsECI #ZDMSociety

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5 months ago
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At #ZDM18 on Weds 15th Oct, we are excited to have @francoiskroll.bsky.social talk about “CRISPR prime editing made precise and highly efficient by inhibition of microhomology-mediated end-joining” #zdmsECI #ZDMSociety

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5 months ago
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Upfront Menin-inhibitor resistance in multiply pretreated leukemias 10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...

Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...

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5 months ago
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All set for ZDM18?! Check out the stellar line-up of speakers in the Cancer Biology-2 Plenary on Day 3 of #ZDM18! Yann Gibert will be sharing his work on TPR blockade-induced disruption of platelet-tumor cell interactions in TNBC #ZDMSociety #zdmsECI

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5 months ago
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We are looking forward to Daniel Cifuentes' talk on 'Determining the Risk of Blood Disorders in Aging LESKRES Patients Using Zebrafish Models' at #ZDM18 #zdmsECI #ZDMSociety

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5 months ago
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Next up, we have Stephanie Tsai who will speak about regenerative programs at the tendon. #ZDM18 #zdmsECI #ZDMSociety

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5 months ago
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Excited for Anna Moyer's @annamoyer.bsky.social talk at #ZDM18: 'Overexpression screen of chromosome 21 orthologs establishes erg as a potent regulator of neurodevelopment'. #zdmsECI #ZDMSociety

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5 months ago
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Don't miss the amazing line-up of talks in the 'Ageing and Adult Disease Models' session at #ZDM18. Featuring Caghan Kizil
@cakizil.bsky.social who will be speaking about 'Blood-Brain Barrier Pathophysiology and Therapeutic Opportunities in Alzheimer’s Disease' #zdmsECI #ZDMSociety

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5 months ago
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Check out Matt Hamilton's talk to learn about how macrophages regulate cholesterol metabolism in the liver #zdmsECI #ZDM18 #ZDMSociety

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5 months ago
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Don't miss Alberto Rissone's talk on zebrafish models of lysosomal disorders! #zdmsECI #ZDM18 #ZDMSociety

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5 months ago
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Today, we #zdmsECI are highlighting three excellent speakers from the GI and Metabolic Disease session at #ZDM18 #ZDMSociety. Meet Patrice Delaney @patrice-delaney.bsky.social, who will be speaking about the implications of estrogen activity for pregnancy-associated liver adaptations.

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5 months ago
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Check out Edward Burton's talk highlighting Brd4 as a regulator of microglial synaptic elimination in progressive supranuclear palsy! #ZDM18 #zdmsECI #ZDMSociety

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5 months ago
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Happy Hump Day! Today, we are highlighting two exciting ZDM talks on neurological disorders. We have our very own Antonella Lauri speaking about zebrafish models of COL4A1/A2 syndrome. #ZDM18 #zdmsECI #ZDMSociety

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5 months ago
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Next up is Clay Foster. He will be giving a talk titled “Integrated Analysis of
Transcriptional and Replicative Dysregulation Reveals Candidate Drivers of MYC-Mediated Leukemogenesis”. #ZDM18 #ZDMSociety #zdmsECI

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5 months ago
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#zdmsECI is excited to showcase our #zdm18 oral abstract presenters. First up is Elena Vasileva. She will be giving a talk titled “Development of Ewing Sarcoma Through Embryonic Reprogramming of Neural Crest to Mesoderm”. #ZDMSociety

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5 months ago
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We are looking forward to @benjhogan.bsky.social's (Peter Mac, Uni of Melbourne) talk at #ZDM18! Ben will sharing his lab's work on using sc-genomic approaches to explore lymphatic development, regeneration and the blood brain barrier. Don't miss his talk on Oct. 13th at 14:30 in Boston or online!

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5 months ago
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We are excited to have Catarina M Henriques (University of Sheffield) at #ZDM18. She will be talking about her lab's work on telomerase's protective role in the zebrafish brain and how it is required for blood brain barrier integrity. Don't miss her talk on Oct. 15th at 11:00 in Boston or online!

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5 months ago
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We're excited to have Carine Smith from Stellenbosch University at #ZDM18 in Boston! Carine's talk "Autism spectrum disorder: from brain to gut" will be kicking off the GI and Metabolic Disease session on Oct. 14 at 11:00.
ZDMS will also have virtual access for the first time this year!

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6 months ago
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Stoked to have Maura McGrail @mcgraillab.bsky.social, Iowa State University, at #ZDM18. Don’t miss her talk “Modeling neural development and disease with Cre/lox cell type-specific knockout” in the Technological Advances and Drug Discovery session on Oct 15th at 9:00 AM. #ZDMSociety #zdmsECI

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6 months ago
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Next up, we are highlighting Sarah McMenamin from Boston College. Interested in skeletal development and endocrinology? Don’t miss Sarah’s talk in the Plenary session on Regeneration and stem cells at #ZDM18 on October 13th at 4:30 pm! #ZDMSociety #zdmsECI

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6 months ago
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We’re honored to welcome Len Zon, a zebrafish trailblazer who needs no introduction. Catch his talk in the Cancer Biology Plenary session at #ZDM18 on October 15th at 3:15 pm! #ZDMSociety #zdmsECI ZDM offers virtual access for the first time - join us from anywhere!

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6 months ago
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Next up in our #ZDM18 speaker series is keynote speaker Dr. David Langenau! His lab transformed cancer biology research by innovating some of the first zebrafish pediatric cancer models. #zdmsECI Don’t miss his talk this October in Boston!

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6 months ago
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Meet our first #ZDM18 keynote: Dr. Cassandra Extavour!
Her pioneering work in germ cell development has reshaped how we think about early embryogenesis across species. Can’t wait to hear her insights at ZDM18! #zdmsECI #ZDMSociety Abstract submission is open until September 12th!

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6 months ago

Hey zebrafish folks! Super excited to kick off a speaker spotlight series for the ZDM Conference happening this October in Boston! Watch this space and be sure to retweet!
#zdmsECI #ZDM18

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7 months ago
Preview
NASP modulates histone turnover to drive PARP inhibitor resistance - Nature PARP inhibitor treatment triggers histone release from the chromatin in cancer cells; consequently, targeting the histone chaperone NASP renders cells vulnerable to PARP inhibition.

Thrilled to share our latest work, just published in @nature.com ⬇
www.nature.com/articles/s41...

We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors.
🧵 (1/8)

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8 months ago

Three weeks before abstract submission and early bird registration close for ZDM18, at Boston this year! Discounts for attendance by multiple lab members: contact info@zdmsociety.org #ZDM18

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