Alice Jenkins

What’s the conclusion? We can say that hydroquinine shows a definite reduction in the bacterial growth of P.aeruginosa from the study. However, this isn’t the end of the story as it is crucial to investigate exactly how hydroquinine operates to inhibit growth of MDR PA. @pathsci2baldock.bsky.social

The ADI-pathway is being used by binding hydroquinine directly to the pathway using a technique called molecular docking analysis. The technique allows them to locate the potential binding sites which are used to observe the interactions created by hydroquinine and can help with future drug design.

The arginine deiminase (ADI) pathway provides bacterial energy for P.aeruginosa when the bacteria is in environments low in oxygen. The functional genes, arcA, arcB, arcC and arcD, as seen below, are needed to supply bacteria with ATP, along with the arginine-ornithine antiporter.

Hydroquinine is shown to have a greater effect when combined with an antibiotic called ceftazidime. The concentration of both hydroquinine and ceftazidime is reduced, resulting in an efficient outcome when inhibiting and killing clinical PA-S4 and PA-S5 isolates.

How effective is hydroquinine for clinical PA strains? The results show that hydroquinine was successful in the inhibition and killing of the clinical and drug-sensitive strains, when given at a concentration of 2.50 and 5.00 mg/mL for the minimum inhibitory and bacterial concentrations, seen below.

Hydroquinine is one of the methods being studied to slow down the growth of clinical MDR PA. It is a compound typically used to lighten dark pigmentation on skin (3) and has recently been discovered to have the ability to kill bacteria with use of antibacterial activity.

There are various strains of MDR PA from multiple bacterial sources, including PA-S1, PA-S2, PA-S3 etc. Each will have a different effectiveness from the new solutions being developed by researchers. This is due to antimicrobial resistance (AMR) which causes changes in the genetics of the bacteria.

What Is Pseudomonas Aeruginosa? Pseudomonas aeruginosa is a common germ can cause infections that are tough to treat. Here's what you should know to stay safe.

A type of MDR strain is Pseudomonas aeruginosa (PA) bacterium found in the environment, with very limited treatment options due to resistance to treatment. PA commonly causes infections to those within a hospital setting and will develop symptoms that are difficult to eliminate. Read further below:

Hydroquinine Inhibits the Growth of Multidrug-Resistant Pseudomonas aeruginosa via the Suppression of the Arginine Deiminase Pathway Genes - PubMed Hydroquinine has antimicrobial potential with demonstrated activity against several bacteria, including multidrug-resistant (MDR) <i>P. aeruginosa</i> reference strains. Despite this, there is limited...

Multidrug resistance (MDR) is a concerning problem worldwide. MDR is when microorganisms evolve to develop resistance against drugs, decreasing the effect of treatment for common infections, making it harder to control. Luckily, researchers are currently developing new methods to solve this problem.

How effective is hydroquinine for clinical PA strains? The results show that hydroquinine was successful in the inhibition and killing of both the clinical and drug-sensitive strains, when given at a concentration of 2.50 and 5.00 mg/mL for the minimum inhibitory and bacterial concentrations.

Hydroquinine is one of the methods being studied to slow down the growth of clinical MDR PA. It is a compound typically used to lighten dark pigmentation on skin and has recently been discovered to have the ability to kill bacteria with use of antibacterial activity.

There are various strains of MDR PA from multiple bacterial sources, including PA-S1, PA-S2, PA-S3 etc. Each will have a different effectiveness from the new solutions being developed by researchers. This is due to antimicrobial resistance (AMR) which causes changes in the genetics of the bacteria.

What Is Pseudomonas Aeruginosa? Pseudomonas aeruginosa is a common germ can cause infections that are tough to treat. Here's what you should know to stay safe.

A type of MDR strain is Pseudomonas aeruginosa (PA) bacterium found in the environment, with very limited treatment options due to resistance to treatment. PA commonly causes infections to those within a hospital setting and will develop various symptoms that are difficult to eliminate.