This exciting manuscript tour is nearly to an end. Today we are highlighting a cardiomyocyte study by Blandine Chazarin and Jennifer E. Van Eyk www.ahajournals.org/.... This innovative single-cell proteomics study reveals deep proteome heterogeneity and offers new insights into cardiac biology.

Excited to explore cancer across dozens of tumor types? Dive into this comprehensive pan-cancer proteome atlas by Mengge Lyu and Connie R. Jimenez that uses mass spectrometry to map protein landscapes and uncover new biology, biomarkers and therapeutic avenues: www.cell.com/cancer-...

Frontiers | Extracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems Background: Newer 3D culturing approaches are a promising way to better mimic the in vivo tumor microenvironment and to study the interactions between the he...

Interested in tumor microenvironment dynamics? Check out this compelling study by Martina Schuster and Marlene Reithmair showing how 3D glioblastoma organoids secrete extracellular vesicles with distinct immune signaling cargo compared to traditional 2D cultures:

Privacy-preserving multicenter differential protein abundance analysis with FedProt Nature Computational Science - In this Resource, the authors present FedProt, a tool that enables privacy-preserving, federated differential protein abundance analysis across multiple institutions....

Yuliya Burankova and Olga Zolotareva are demonstrating in their exciting paper how to perform a mulicenter MS proteomics analysis on clinical samples. Today on Countdown day 10, you should really check it out:

Struggling with robustness and throughput in single-cell proteomics? Check out this thorough workflow optimization study from Pauline Perdu-Alloy and Christine Carapito that pushes label-free SCP toward reproducible, high-depth, high-throughput analysis:

Astrogliosis and neuroinflammation underlie scoliosis upon cilia dysfunction Brain ventricular astrogliosis and neuroinflammation precede scoliosis onset in the zebrafish rpgrip1l ciliary mutant and anti-inflammatory treatment drastically reduces scoliosis while correcting urotensin related peptide level is ineffective.

Countdown day 9. Today, we highlight the manuscript from Morgane Djebar & Christine Vesque from a fascinating zebra fish study that links ciliary defects to neuroinflammation and astrogliosis as drivers of scoliosis. If you are interested in cilia then check it out: elifesciences.org/ar...!

Countdown day 7 is here to get your R skills rolling with an updated workflow from Charlotte Hutchings and Lisa M. Breckels. If you are looking to analyse protein subcellalur locations and still need a way to analyse the data, please check it out:

High-throughput peptide-centric local stability assay extends protein–ligand identification to membrane proteins, tissues and bacteria Nature Structural & Molecular Biology - Li et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends...

Want to explore protein–ligand interactions at unprecedented scale and speed? Check out this exciting high-throughput adaptation from Keija Li and Mira Lea Burtscher that dramatically broadens detection across tissues, bacteria and even tricky membrane proteins:

Hesitant to do proteomics on bacteria? Check out this fantastic publication from Miram Abele and Christina Ludwig highlighting the possibilities and benefits as well as supplying resources to help along the way: www.mcponline.org/ar...

Day 4 is to celebrate Xiaofang Zhong and Ruth Hüttenhain and their amazing manuscript, where you can learn how to map spatial proteomes with better consistency. Check out this streamlined proximity proteomics pipeline that boosts throughput and reproducibility: pubmed.ncbi.nlm.nih....

Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications - PubMed Proteins regulate biological processes by changing their structure or abundance to accomplish a specific function. In response to a perturbation, protein structure may be altered by various molecular events, such as post-translational modifications, protein-protein interactions, aggregation, alloste …

How do protein structures shift across thousands of molecules at once? Dive into this powerful protocol that opens the door to proteome-wide structural insights using limited proteolysis-mass spectrometry.
Check it out with Liliana Malinovska & Paola Picotti: pubmed.ncbi.nlm.nih.gov/36526727/

In two weeks, we celebrate the International Day of Women & Girls in Science. This year, we’re marking the occasion by highlighting 14 outstanding manuscripts with inspiring women as first and last authors — each with a short teaser to spark your curiosity. Explore, discover, and celebrate with us ✨

Don’t miss the chance to present your work, connect with peers, and be part of an exciting day dedicated to proteomics!

📢 3rd YPIC Annual Proteomics Gathering – Preliminary Program Out Now!

We’re excited to share the preliminary program for the 3rd YPIC Annual Proteomics Gathering, taking place on 16 April 2026 at the Faculty of Pharmacy, Universidad Complutense de Madrid (Spain) 🇪🇸

#APG2026 #YPIC #Proteomics

Network with peers, presenters, YPIC, and EuBIC in Proteopolis after the webinar (open until 17:00 CEST).
Help spread the word by sharing this post with colleagues and students passionate about proteomics and bioinformatics. Who's in? 🚀

Take part in the 4th European Proteomics Science Slam: submit a 3‑minute video explaining your work in simple, engaging terms (deadline: 31 March 2025; travel grants of 1000€, 800€, and 500€ for the top three videos to attend a EuPA event in 2026 or 2027).

What’s happening:
Meet EuPA’s 2024 ECR and Bioinformatics awardees and hear their stories.
Watch the top-3 videos from EuPA PhD thesis awardee submissions 2026 and help shape the next EuPA Best PhD Thesis Award.

🧪 Online (Zoom)
📅 23 April 2026
⏰ 14:00–16:00 CEST

✅ Free registration is mandatory!

👉More information in comments!

🔗 ECR Day Registration: docs.google.com/forms/d/e/1F...
🔗 Science Slam Registration: docs.google.com/forms/d/e/1F...

#Proteomics #EarlyCareerResearchers #YPIC #EuPA#EuBIC

As they beautifully said, “Early career researchers play a critical role in shaping the future of science and innovation.”, which we completely agree with. Their commitment to fostering early career researchers aligns perfectly with the mission of YPIC.

We are thrilled to have IonOpticks again as our long-standing sponsor of the Student Proteomics Fund (SPF)! 🙌

Thank you, IonOpticks, for your continued support and for helping make a difference in the world of science! 🔬💡

#YPIC #SPF #Ionopticks

Don’t miss this opportunity!
we’re looking forward to your contributions!

🗓 Date: 16 April 2026
📍 Location: Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
💶 Registration: Free
📝 Abstract submission deadline: 7 February
🖊 Registration opens: 15 February.
Students and early career researchers in Europe are welcome!

📢 Abstract Submission Now Open!

This is your chance to showcase your research at the 3rd Annual Proteomics Gathering in Madrid! 🇪🇸🧬

Submit your abstract easily via the QR code or the link below:
docs.google.com/forms/d/e/1F...

#APG2026 #YPIC #Proteomics #EarlyCareerResearchers #EuPA

👀 Stay tuned for the updates and announcements about abstract submission dates.
Looking forward receiving your registrations and seeing you at the symposium!

The symposium warmly welcomes researchers outside Finland as well.

‼️ The early bird registration will last 𝐮𝐧𝐭𝐢𝐥 𝟑𝟎.𝟏.𝟐𝟎𝟐𝟔. Be quick to secure your spot for the lower price!

Finnish Proteomics Society has opened the early bird registration for the 2026 Finnish Proteomics Symposium 🥳
Don’t miss this opportunity to share your research, connect with leading experts, and explore the latest advancements in proteomics in picturesque surroundings of Nuuksio National Park.

📣 Please share with colleagues and networks who should not miss this opportunity.

#PhDLife #Bioinformatics #ScienceCommunication

EuPA invites applications for five prestigious awards:
🔹 Best Doctoral Thesis
🔹 Bioinformatics for Mass Spectrometry
🔹 Vision and Commitment
🔹 Breakthrough in Proteomics
🔹 Science Outreach

This is your opportunity to showcase excellence, innovation, and impact across the proteomics community.

🏆 EuPA Awards 2026 – Applications Open!
Are you pushing the boundaries in proteomics?
Or do you know someone whose work truly deserves recognition?
📅 Applications open: 18 December 2025
⏳ Deadline: 14 February 2026
👉 Learn more & apply: eupa.org/eupa-awards-...

#EuPA #Proteomics #MassSpectrometry

EuPA invites applications for five prestigious awards:
🔹 Best Doctoral Thesis
🔹 Bioinformatics for Mass Spectrometry
🔹 Vision and Commitment
🔹 Breakthrough in Proteomics
🔹 Science Outreach
This is your opportunity to showcase excellence, innovation, and impact across the proteomics community.