@christoseland.bsky.social
Prof. Cancer Biophysics at University of Sheffield. Investigating Nuclear Myosin, Nuclear Organisation and Mechanobiology in Cancer with single molecule Biophysics Web: Toseland-lab.com
Save the date!
We have an exciting conference coming up next year for the UK Mechanobiology community!
It was great to collaborate with Javier Redondo Muñoz in this project and I am very happy to see it in press:
www.cell.com/cell-reports...
We are very proud that Thalia has been nominated for three Yorkshire Choice awards - Please vote here: www.yorkshirechoiceawards.co.uk/vote
Three years ago, Thalia was diagnosed with a devastating brain tumour. She has fought back and done her best to raise awareness and funds to support others!
Registration deadline 20th Dec! We have generous travel grants for early career researchers! April is a beautiful time to visit China!
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉
Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨
#PhD #3DGenome
In this work we show that you don’t have to target the main players in disease….instead you identify and target what they depend on!
We're still accepting submissions for our 'Cell Biology of the Nucleus' special issue, which is being guest edited by
@abbybuch.bsky.social and Megan King (@luskinglab.bsky.social).
Submission deadline: 5 January
journals.biologists.com/jcs/pages/nu...
#nucleus #notforprofit #freetopublish
Thanks @grosselab.bsky.social there is another nice one coming soon!
Myosin VI orchestrates estrogen-driven gene expression in breast cancer cells. https://www.biorxiv.org/content/10.1101/2025.11.13.688007v1
Perturbation of Myosin VI enhances the effect of endocrine therapies. Moreover, Myosin VI is still required for hormone-independent ER mutants thereby providing a potential avenue to overcome therapy resistance.
We are very happy to share our new PrePrint: Myosin VI orchestrates estrogen-driven gene expression in breast
cancer cells. www.biorxiv.org/content/10.1...
We characterise how Myosin VI is a key regulator of the Estrogen Receptor. Perturbation of Myosin VI impedes ER functionality.
A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social
An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project...
#CellBio #SuperResolutionMicroscopy
#MolecularBio #AgeingResearch #PhDOpportunity
🔬Want to develop a blood test for dementia? A fully funded PhD position is available in our lab to probe and detect single molecules! Join our team @york.ac.uk
! Find out more & apply by 4th Dec:
tinyurl.com/yt36p9tx
@ybri-uoy.bsky.social @ei-science.bsky.social @timcraggs.bsky.social
Please repost - Multiple PhDs available
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
www.findaphd.com/phds/project...
Please Repost!
Tobi Zach and I have an MRC DiMeN PhD position available! Come join us!
www.findaphd.com/phds/project...
It’s Halloween so time to make the cells scream!
Excited for our next special issue and looking forward to working with Abby Buchwalter (@abbybuch.bsky.social) and Megan King (@luskinglab.bsky.social)! Working on the cell biology of the nucleus? Send your papers our way!
#notforprofit
Phantastic review of SPT method and analysis. Great resource for every single molecule tracking enthusiast! Congratulations, @gebhardtlab.bsky.social
Yesterday we had the School of Medicine and Population Health PGR symposium - a fantastic range of talks and posters from our students!
We had excellent career sessions from Faith Nutter Howard David King and Amy Turner
Thanks to our ECRs who gave a useful and honest take on finishing a PhD.
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
Doubling up on the measurements and toys today - so great and useful to have this kit next door to each other!
Postdoc positions open in my lab (Francis Crick Institute) to study
1. initiation of DNA replication.
2. chromatin replication/epigenetic inheritance.
Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.
Deadline 3 August 2025.
crick.wd3.myworkdayjobs.com/External/job...
This is a piece that I and @karsten-rippe.bsky.social discussing a lot, and a topic that is very close to my heart. The editors @naturerevgenet.bsky.social gave us the stage to do so, and the final version of our review is now available under this link: rdcu.be/erP1u
A short thread follows 1/n
The QS World University Rankings 2026 have just been released and we’ve placed 92nd within the World Top 100! Huge congratulations and thanks to everyone in the University of Sheffield community for this achievement; from staff and students to alumni, supporters and friends around the world!
🚀 Manual mask annotation slowing you down?
💡 SAMJ is a new ImageJ/Fiji plugin using Segment Anything (SAM) for fast, interactive segmentation — no GPU needed, one-click install, real-time results.
🔬 Perfect for large biomedical images.
arxiv.org/abs/2506.02783
#AI #Bioimaging #ImageJ #OpenSource
If heterochromatin is really a liquid-like condensate, why is it not spherical?
We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments
www.biorxiv.org/content/10.1...
Amazing news - many congrats!
Needing to be everywhere all at once….Drove down at lunch with the samples