Velindre Library

Episode 171: Clinical Application of the Microbiome with International Expert Professor Monty Pal City of Hope California

Best audio accompaniment for putting up Christmas decs? Obviously, it's the new Immunobuddies! Episode 171: Clinical Application of the Microbiome with International Expert Professor Monty Pal City of Hope California. @velindrecc.bsky.social @rickyfrazer1.bsky.social open.spotify.com/episode/1QtM...

Radiotherapy for Oesophageal Cancer in the United Kingdom: Patterns of Practice and Quality Indicators There is limited guidance relating to the provision of radiotherapy for patients with oesophageal cancer. Given this, we sought to assess variation in…

Radiotherapy for Oesophageal #Cancer in the United Kingdom: Patterns of Practice and Quality Indicators @velindrecc.bsky.social www.sciencedirect.com/science/arti...

BPS Publications Clopidogrel, an antiplatelet agent, is currently licensed in the United Kingdom for the prevention and treatment of atherothrombotic events in cerebrovascular disease, coronary artery disease and per...

CYP2C19 genotype testing for clopidogrel: A guideline developed by the UK Centre of Excellence for regulatory science and innovation in pharmacogenomics (CERSI-PGx). @velindrecc.bsky.social bpspubs.onlinelibrary.wiley.com/doi/10.1002/...

Glofitamab with gemcitabine and oxaliplatin for treating relapsed or refractory diffuse large B-cell lymphoma. www.nice.org.uk/guidance/ta1...

NICE [Technology Appraisal Guideline]: Talquetamab for treating relapsed and refractory multiple myeloma after 3 or more treatments. www.nice.org.uk/guidance/ta1...

The use of tramadol for cancer-associated pain—a systematic review - Supportive Care in Cancer Background Tramadol has been used for cancer pain and reported in the literature with varying relative effects compared to other analgesics. To our knowledge, there is no comprehensive systematic revi...

The use of tramadol for cancer-associated pain—a systematic review. link.springer.com/article/10.1...

I want to get better; I don’t want to just stay at home: a theory-driven qualitative exploration of participation in a home-based lung cancer exercise clinical trial - Supportive Care in Cancer Purpose We conducted a multi-site randomised controlled trial (RCT) of home-based exercise and self-management for patients after lung cancer surgery, which improved the intervention group’s exercise ...

I want to get better; I don’t want to just stay at home: a theory-driven qualitative exploration of participation in a home-based #LungCancer exercise clinical trial. link.springer.com/article/10.1...

Noninferiority of One HPV Vaccine Dose to Two Doses. #CervicalCancer www.nejm.org/doi/full/10....

Lorlatinib in Tyrosine Kinase Inhibitor−Naive Advanced ROS1-Positive Non−Small Cell Lung Cancer This multicenter nonrandomized clinical trial evaluates the efficacy and safety of lorlatinib for patients with advanced ROS1-positive non−small cell lung cancer who have not been treated with a tyros...

Lorlatinib in Tyrosine Kinase Inhibitor−Naive Advanced ROS1-Positive Non−Small Cell #LungCancer: A Phase 2 Nonrandomized Clinical Trial. jamanetwork.com/journals/jam...

Person-centred approach for people with learning disabilities in palliative care: the challenges Background People with a learning disability (PWLD) are living longer with a greater need for palliative care. Research has identified that people with a learning disability experience challenges when...

Person-centred approach for people with learning disabilities in palliative care: the challenges. spcare.bmj.com/content/earl...

STELLAR: Phase III, Randomized, Open-Label Study of Eflornithine Plus Lomustine Versus Lomustine Alone in Patients With Recurrent Grade 3 Astrocytoma. ascopubs.org/doi/10.1200/...

Amivantamab Plus Lazertinib in Atypical <i>EGFR</i>-Mutated Advanced Non–Small Cell Lung Cancer: Results From CHRYSALIS-2 PURPOSEFor patients with advanced non–small cell lung cancer (NSCLC) harboring atypical epidermal growth factor receptor (EGFR) mutations (eg, S768I, L861Q, G719X), efficacy of current treatment optio...

Amivantamab Plus Lazertinib in Atypical EGFR-Mutated Advanced Non–Small Cell #LungCancer: Results From CHRYSALIS-2. ascopubs.org/doi/10.1200/...

Atezolizumab With Bevacizumab and Nonplatinum Chemotherapy for Recurrent Ovarian Cancer: Final Results From the Placebo-Controlled AGO-OVAR 2.29/ENGOT-ov34 Phase III Trial PURPOSETo evaluate atezolizumab combined with bevacizumab and non–platinum-based chemotherapy for recurrent ovarian cancer.METHODSThe double-blind randomized phase III AGO-OVAR 2.29/ENGOT-ov34 trial (...

Atezolizumab With Bevacizumab and Nonplatinum Chemotherapy for Recurrent #OvarianCancer: Final Results From the Placebo-Controlled AGO-OVAR 2.29/ENGOT-ov34 Phase III Trial. ascopubs.org/doi/10.1200/...

Peri-operative tislelizumab plus neoadjuvant chemotherapy for patients with resectable non-small cell lung cancer: final analysis of the randomized RATIONALE-315 trial Peri-operative immunotherapy, particularly anti-programmed cell death protein-1 therapy, combined with neoadjuvant chemotherapy has emerged as one of the standard-of-care options for resectable non-sm...

Peri-operative tislelizumab plus neoadjuvant chemotherapy for patients with resectable non-small cell #LungCancer: final analysis of the randomized RATIONALE-315 trial. www.annalsofoncology.org/article/S092...

5-Year Outcomes of Moderately Hypofractionated Whole Pelvic Radiotherapy with Concurrent Chemotherapy and Image Guided High Dose Rate Brachytherapy for Locally Advanced Cervical Carcinoma Although moderately hypofractionated external beam radiotherapy (H-EBRT) has been practiced for locally advanced cervical carcinoma (LACC), prospective evidence remains limited. We evaluated the role ...

5-Year Outcomes of Moderately Hypofractionated Whole Pelvic Radiotherapy with Concurrent Chemotherapy and Image Guided High Dose Rate Brachytherapy for Locally Advanced Cervical Carcinoma. www.redjournal.org/article/S036...

Effects of Nutritional Interventions on Quality of Life in Patients with Nasopharyngeal Carcinoma Undergoing Radiotherapy Based on Dynamic Nutritional Risk Screening and Assessment: An Open-label Sing... : Malnutrition is common among patients with nasopharyngeal carcinoma (NPC) undergoing radiotherapy and is associated with diminished quality of life (QoL). However, the impact of individualized nutri...

Effects of Nutritional Interventions on Quality of Life in Patients with Nasopharyngeal Carcinoma Undergoing Radiotherapy Based on Dynamic Nutritional Risk Screening and Assessment: An Open-label Single-center Randomized Phase 3 Trial. www.redjournal.org/article/S036...

ESTRO-ISRS clinical practice recommendations for re-irradiation of spinal mestastases with Stereotactic body radiotherapy: delphi consensus supported by a systematic review and meta-analysis Stereotactic body radiotherapy (SBRT) is an established treatment for previously unirradiated spinal metastases; however, the literature is limited wi…

ESTRO-ISRS clinical practice recommendations for re-irradiation of spinal mestastases with Stereotactic body radiotherapy: delphi consensus supported by a systematic review and meta-analysis. www.sciencedirect.com/science/arti...

Cumulative dose evaluation in clinical reirradiation – Consensus guidance on technical considerations by the ESTRO reirradiation focus group Reirradiation is increasingly used, but its safe application requires accurate evaluation of cumulative doses to organs at risk. Methods of cumulative…

Cumulative dose evaluation in clinical reirradiation – Consensus guidance on technical considerations by the ESTRO reirradiation focus group. www.sciencedirect.com/science/arti...

Clustering of dosimetric profiles reveals distinct local control probabilities after SABR in oligometastatic head and neck cancer: insights from the OMET phase II trial quality assurance Process Stereotactic ablative radiotherapy (SABR) is increasingly used in the management of oligometastatic disease. However, variability in SABR plans raises…

Clustering of dosimetric profiles reveals distinct local control probabilities after SABR in oligometastatic head and neck #Cancer: insights from the OMET phase II trial quality assurance Process. www.thegreenjournal.com/article/S016...

The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): a randomized open-label phase 2 study Immune checkpoint inhibitor (ICI) combinations have improved outcomes in patients with advanced melanoma; however, long term survival remains poor. The addition of therapeutic cancer vaccines to ICI c...

The telomerase vaccine UV1 combined with ipilimumab and nivolumab versus ipilimumab and nivolumab in advanced melanoma (INITIUM): a randomized open-label phase 2 study. www.ejcancer.com/article/S095...

Prediction of HER2 Changes post-Neoadjuvant Therapy based on Fusion of Ultrasound Radiomics and Clinicopathological Features Empowered by Explainable AI: a Multicenter Study Dynamic HER2 expression changes during neoadjuvant therapy (NAT) challenge precision oncology. Current biopsy-dependent evaluation inadequately meets clinical needs for dynamic monitoring. We develope...

Prediction of HER2 Changes post-Neoadjuvant Therapy based on Fusion of Ultrasound Radiomics and Clinicopathological Features Empowered by Explainable AI: a Multicenter Study. www.ejcancer.com/article/S095...

Combination of predicted sensitivity to endocrine therapy (SET2,3 index) and the Recurrence Score® in node-positive breast cancer: independent validation in the PACS-01 trial. To independently confirm whether the combination of sensitivity to endocrine therapy (SET2,3) index and Recurrence Score® (RS) improves prognostic assessment for patients with hormone receptor-positiv...

Combination of predicted sensitivity to endocrine therapy (SET2,3 index) and the Recurrence Score® in node-positive #BreastCancer: independent validation in the PACS-01 trial. www.ejcancer.com/article/S095...

Radiotherapy plan quality assurance in the ABC-07 trial of stereotactic body radiotherapy (SBRT) for locally advanced biliary tract #Cancer. www.clinicaloncologyonline.net/article/S093...

Electronic health record-facilitated symptom surveillance and collaborative care intervention in oncology (E2C2): a cluster-randomised, population-level, stepped-wedge, pragmatic trial Centralised EHR-facilitated, symptom surveillance and collaborative care management are more beneficial than symptom surveillance alone in reducing the population burden of SPPADE symptoms in oncology...

Electronic health record-facilitated symptom surveillance and collaborative care intervention in oncology (E2C2): a cluster-randomised, population-level, stepped-wedge, pragmatic trial. www.thelancet.com/journals/lan...

Episode 170: New Immunotherapies for Community Teams and Non-Oncologists Final Part with Macmillan GP Lead for Wales Dr Elise Lang

The weekly wait is over - The Immunobuddies are here! Episode 170: New Immunotherapies for Community Teams and Non-Oncologists Final Part with Macmillan GP Lead for Wales Dr Elise Lang. @velindrecc.bsky.social @rickyfrazer1.bsky.social open.spotify.com/episode/0zds...

Under-Representation of Black and Hispanic Men in Metastatic Castration-Resistant Prostate Cancer Trials (2005-2021): A Call to Action | JCO Oncology Practice PURPOSEBlack men face the highest incidence and mortality rates of prostate cancer globally, including a disproportionate burden of metastatic castration-resistant prostate cancer (mCRPC). Despite thi...

Under-Representation of Black and Hispanic Men in Metastatic Castration-Resistant #ProstateCancer Trials (2005-2021): A Call to Action. ascopubs.org/doi/10.1200/...

Durvalumab plus platinum-etoposide in the first-line treatment of extensive-stage small cell lung cancer (CANTABRICO): A single-arm clinical trial Extensive-stage small cell lung cancer (ES-SCLC) accounts for more than two-thirds of SCLC cases at the time of diagnosis and is associated with poor prognosis, with a 5-year overall survival (OS) rat...

Durvalumab plus platinum-etoposide in the first-line treatment of extensive-stage small cell #LungCancer (CANTABRICO): A single-arm clinical trial. www.lungcancerjournal.info/article/S016...

Very Long‐Term Follow‐Up of Multidimensional Health‐Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study Background To evaluate postoperative health-related quality of life (HRQoL) for pituitary adenoma patients, multidimensional assessment is important. Available data is limited on long-term follow-up...

Very Long-Term Follow-Up of Multidimensional Health-Related Quality of Life After Endoscopic Endonasal Surgery for Pituitary Adenomas: A Prospective Cohort Study onlinelibrary.wiley.com/doi/10.1002/...

Bevacizumab plus chemotherapy versus chemotherapy in untreated advanced non-squamous non-small-cell lung cancer patients with brain metastases (BAP BRAIN): an open-label, randomized, multicenter, phas... There is a lack of prospective randomized controlled trials of antiangiogenic therapy in patients with brain metastases. We conducted this phase III, randomized, multicenter study (BAP BRAIN) to evalu...

Bevacizumab plus chemotherapy versus chemotherapy in untreated advanced non-squamous non-small-cell #LungCancer patients with brain metastases (BAP BRAIN): an open-label, randomized, multicenter, phase III study. www.esmoopen.com/article/S205....

Long-term outcome data for patients with hormone receptor-positive early #BreastCancer participating in the WSG PlanB trial after preselection by gene expression analysis: 10-year survival results from the WSG PlanB registry. www.esmoopen.com/article/S205...