Velindre Library

Immunobuddies - posing important questions in humorous ways. Episode 181: RS3PE - A WIFI password from the 90's or an actual toxicity? @velindrecc.bsky.social @rickyfrazer1.bsky.social open.spotify.com/episode/4Lfw...

Hemophagocytic Lymphohistiocytosis Secondary to Immunotherapy Toxicity in a Patient With Breast Cancer: A Case Report Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal hyperinflammatory syndrome marked by abnormal activation of the immune system, resulting in widespread tissue destruction and m...

Hemophagocytic Lymphohistiocytosis Secondary to Immunotherapy Toxicity in a Patient With #BreastCancer: A Case Report. @velindrecc.bsky.social @rickyfrazer1.bsky.social. www.cureus.com/articles/441...

International analysis of reimbursement rates and clinical benefit of genitourinary cancer drugs across Canada, France, England, Wales, Scotland, Spain, Italy, and Portugal The international landscape of cancer drug reimbursement across countries with national healthcare systems is often poorly described. This analysis of genitourinary cancer drug reimbursement rates in...

International analysis of reimbursement rates and clinical benefit of genitourinary #Cancer drugs across Canada, France, England, Wales, Scotland, Spain, Italy, and Portugal @velindrecc.bsky.social @rickyfrazer1.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

NCCN Guideline Insight: Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate, Version 2.2026 jnccn.org/configurable...

NCCN Guideline: Hodgkin Lymphoma Version 1.2026 jnccn.org/view/journal...

NICE Technology Appraisal Guideline [TA1130]: Talazoparib with enzalutamide for untreated hormone-relapsed metastatic #ProstateCancer. www.nice.org.uk/guidance/ta1...

NICE Technology Appraisal Guideline [TA1129]: Niraparib for maintenance treatment of advanced ovarian, fallopian tube and peritoneal #Cancer after response to first-line platinum-based chemotherapy. www.nice.org.uk/guidance/ta1...

Comorbidity, treatment toxicity and satisfaction with cancer care: an international cross-sectional study based on the EORTC PATSAT-C33 and OUT-PATSAT7 - Supportive Care in Cancer Purpose This multi-national cross-sectional study assessed socio-demographic and clinical determinants of satisfaction with cancer care in patients enrolled from hospital inpatient and outpatient sett...

Comorbidity, treatment toxicity and satisfaction with #Cancer care: an international cross-sectional study based on the EORTC PATSAT-C33 and OUT-PATSAT7. link.springer.com/article/10.1...

Intensive nursing interventions for post-treatment anxiety and depression in bladder cancer: A systematic review and meta-analysis - Supportive Care in Cancer Background & aims Post-treatment anxiety and depression are prevalent but often underrecognized among bladder cancer patients. This systematic review and meta-analysis aimed to estimate the pooled pre...

Intensive nursing interventions for post-treatment anxiety and depression in #BladderCancer: A systematic review and meta-analysis. link.springer.com/article/10.1...

Salvage Focal Therapy vs Radical Prostatectomy for Localized Radiorecurrent Prostate Cancer This cohort study compares cancer control and perioperative complications among patients after salvage focal therapy vs salvage radical prostatectomy.

Salvage Focal Therapy vs Radical Prostatectomy for Localized Radiorecurrent #ProstateCancer. jamanetwork.com/journals/jam...

Efficacy and safety of pembrolizumab, lenvatinib, and reduced-dose gemcitabine/oxaliplatin as initial treatment for advanced biliary tract cancer: a multicenter, single-arm, prospective, phase II stud... Background Biliary tract cancer (BTC) is an aggressive malignancy with limited treatment options and a poor prognosis. Although immune checkpoint inhibitors combined with chemotherapy have improved pa...

Efficacy and safety of pembrolizumab, lenvatinib, and reduced-dose gemcitabine/oxaliplatin as initial treatment for advanced biliary tract #Cancer: a multicenter, single-arm, prospective, phase II study. jitc.bmj.com/content/14/2...

DART/SWOG/NCI phase II anti-CTLA-4/PD-1 trial: clear cell carcinomas of ovary, endometrium, cervix Background Dual anti-CTLA-4/PD-1 inhibitors show efficacy in numerous malignancies. We are the first to report on the efficacy of ipilimumab-nivolumab immunotherapy in a dedicated cohort of patients w...

DART/SWOG/NCI phase II anti-CTLA-4/PD-1 trial: clear cell carcinomas of ovary, endometrium, cervix jitc.bmj.com/content/14/2...

Standard chemoradiotherapy with concurrent and adjuvant camrelizumab in patients with high risk nasopharyngeal carcinoma: multicentre, randomised, open label, phase 3 trial Objective To assess treatment with camrelizumab (a programmed death 1 inhibitor) in addition to concurrent chemoradiotherapy and as a maintenance treatment in patients with high risk nasopharyngeal ca...

Standard chemoradiotherapy with concurrent and adjuvant camrelizumab in patients with high risk nasopharyngeal carcinoma: multicentre, randomised, open label, phase 3 trial. www.bmj.com/content/392/...

Pivekimab Sunirine in Blastic Plasmacytoid Dendritic Cell Neoplasm. ascopubs.org/doi/10.1200/...

Development and Validation of a Computational Histology Artificial Intelligence–Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic Cancer PURPOSEPredictive biomarkers to guide selection of first-line chemotherapy for advanced pancreatic ductal adenocarcinoma (PDAC) are an unmet clinical need. This study used the Computational Histology ...

Development and Validation of a Computational Histology Artificial Intelligence–Powered Predictive Biomarker for Selection of Chemotherapy in Advanced Pancreatic #Cancer. ascopubs.org/doi/10.1200/...

Transperineal Versus Transrectal Biopsy for Prostate Cancer Diagnosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials Transperineal biopsy is safer than the transrectal approach, with fewer infections and less bleeding despite no antibiotics, while maintaining equal accuracy in prostate cancer detection. Thus, transp...

Transperineal Versus Transrectal Biopsy for #ProstateCancer Diagnosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials. euoncology.europeanurology.com/article/S258...

NALIRIFOX versus nab-paclitaxel and gemcitabine in older patients with treatment-naive metastatic pancreatic cancer: a subgroup analysis of the pivotal NAPOLI 3 trial The phase III NAPOLI 3 trial established liposomal irinotecan in combination with 5-fluorouracil/leucovorin plus oxaliplatin (NALIRIFOX) as a superior first-line (1L) treatment option compared with ge...

NALIRIFOX versus nab-paclitaxel and gemcitabine in older patients with treatment-naive metastatic pancreatic #Cancer: a subgroup analysis of the pivotal NAPOLI 3 trial. www.esmoopen.com/article/S205...

Advanced and metastatic prostate cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Advanced and metastatic #ProstateCancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. www.annalsofoncology.org/article/S092...

Nivolumab plus chemotherapy as first-line treatment for advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma: 5-year follow-up results from CheckMate 649 We report efficacy and safety results from the CheckMate 649 trial after 5 years of follow-up.Adults with previously untreated, non-HER2+, unresectabl…

Nivolumab plus chemotherapy as first-line treatment for advanced gastric, gastroesophageal junction, and esophageal adenocarcinoma: 5-year follow-up results from CheckMate 649. www.sciencedirect.com/science/arti...

Limitations and future directions in identifying risk factors for radiotherapy related pelvic insufficiency fractures in gynecological cancers: A scoping review Gynecological malignancies, including cervical, uterine, and ovarian cancers, are commonly treated with pelvic radiotherapy (RT), either as a primary modality or in conjunction with surgery and chemot...

Limitations and future directions in identifying risk factors for radiotherapy related pelvic insufficiency fractures in gynecological #Cancers: A scoping review. www.thegreenjournal.com/article/S016...

ESTRO technical guideline: intensity modulated radiotherapy and image guided radiotherapy for rectal cancer The standard treatment strategy for many rectal cancer patients includes the use of radiotherapy, either short course radiotherapy (SCRT, 25 Gy in 5 fractions) or long course radiotherapy (LCRT, 45–50...

ESTRO technical guideline: intensity modulated radiotherapy and image guided radiotherapy for rectal #Cancer. www.thegreenjournal.com/article/S016...

Development of radiomics models to predict progression free survival and early polymetastatic progression in patients with lung oligometastases treated on the single-arm phase II SABR-5 trial. www.clinicaloncologyonline.net/article/S093...

Ultra-hypofractionated versus conventionally fractionated radiotherapy for localised prostate cancer (HYPO-RT-PC): 10-year outcomes of an open-label, randomised, phase 3, non-inferiority trial This 10-year follow-up confirms the non-inferiority of the ultra-hypofractionated radiotherapy regimen compared with the conventionally fractionated, with similar toxicity profiles. The findings suppo...

Ultra-hypofractionated versus conventionally fractionated radiotherapy for localised #ProstateCancer (HYPO-RT-PC): 10-year outcomes of an open-label, randomised, phase 3, non-inferiority trial. www.thelancet.com/journals/lan...

National Cancer Plan for England Details the government’s plan to transform cancer care and outcomes in England by 2035.

National #Cancer Plan for England. www.gov.uk/government/p...

It might still be raining, but - new episode of Immunobuddies! Episode 180: Impact of Diet on Immunotherapy and Practical Approaches Final Part with Immunotherapy Dietician Raiatea Van-Reenen University Hospital Derby @velindrecc.bsky.social @rickyfrazer1.bsky.social open.spotify.com/episode/5cr8...

Assessing frailty in older adults with cancer to optimise care provision and outcomes Assessing frailty in older adults with cancer to optimise care provision and outcomes

Assessing frailty in older adults with #Cancer to optimise care provision and outcomes. @velindrecc.bsky.social journals.rcni.com/cancer-nursi...

NICE Technology Appraisal Guideline [TA1127]: Nivolumab with chemotherapy for neoadjuvant treatment then alone for adjuvant treatment of resectable non-small-cell #LungCancer www.nice.org.uk/guidance/ta1...

Effect of early integration of supportive care in addition to standard care in patients with breast cancer: A randomised controlled trial - Supportive Care in Cancer Purpose Breast cancer is the most common malignancy among women in India, with patients often experiencing high symptom burden and compromised quality of life (QoL). Despite evidence supporting early ...

Effect of early integration of supportive care in addition to standard care in patients with #BreastCancer: A randomised controlled trial link.springer.com/article/10.1...

Five-Year Outcome of Camrelizumab Plus Chemotherapy in Recurrent or Metastatic Nasopharyngeal Carcinoma This secondary analysis of a randomized clinical trial examines the long-term survival benefits of adding camrelizumab vs placebo to chemotherapy for patients with recurrent or metastatic nasopharynge...

Five-Year Outcome of Camrelizumab Plus Chemotherapy in Recurrent or Metastatic Nasopharyngeal Carcinoma: A Secondary Analysis of the CAPTAIN-1st Randomized Clinical Trial. jamanetwork.com/journals/jam...

Survival of Patients Diagnosed With Cancer During the COVID-19 Pandemic This cohort study investigates the association of the COVID-19 pandemic with short-term survival among patients diagnosed with cancer in 2020 and 2021 using US population-based cancer registry data.

Survival of Patients Diagnosed With #Cancer During the COVID-19 Pandemic. jamanetwork.com/journals/jam...