Kirk Lohmueller

Symposium 17: Thematic symposium: regulatory genomics and non-coding elements

#SMBE2025

Come join us at UCLA!!! We have a growing population genetics community here and Nandita and her lab are outstanding!

Having major FOMO about #SMBE2025 in my hometown… but I’m very proud that my postdoc, Susanna Gutierrez, will be presenting our work on inferring the selection history of adaptive introgression candidates in Peruvians at poster S12-P19. Please visit her during poster session 3 if you're interested!

Sad to be missing #SMBE2025. But, the lab will be represented with presentations from (all on Wednesday):

Swetha Ramesh (at 11:50 in Symp 17, Noncoding)
Chenlu Di (at 12:05 in Symp 17, Noncoding)
Diana A Gomez (at 15:45 in Symp 19, Con Gen)
Aina Mi Zurita (at 16:40 in Symp 22, Theory Adv)

Congratulations Ran!!!🥳

Congratulations Joana!!!!😀🥳

Evolution of Functional Genomic Diversity During a Bottleneck Abstract. Most species have been through population bottlenecks and range expansions, and the impact of these events on patterns of diversity has been well

Schlichta, Peischl & Excoffier reveal how purifying selection on deleterious mutations impacts diversity: while codominant variants create diversity dips, recessive mutations can preserve diversity in bottlenecks through pseudo-overdominance.

🔗 doi.org/10.1093/gbe/evaf107

#genome #evolution

Kirk with large barrel.

Castle and ruins. But still here. Perhaps a metaphor..

Heidelberg overlooking the Neckar River.

Kirk at Bruce Springsteen concert.

Bruce Springsteen.

Kirk and kids at Bruce Springsteen concert.

Heidelberg castle.

Quick visit to Heidelberg and Frankfurt to visit family and Bruce Springsteen….this helped refresh my soul in these bizarre and trying times.

I hope you feel better soon! I'm sorry we gave you such a yucky souvenir from your visit!

Kirk standing with Bruce Springsteen at his concert at the Kia Forum in LA in 2024.

Thank you @brucespringsteen.net for (yet again) meeting the moment and speaking up for America in these dangerous times...and giving us some hope in the Promised Land.

YouTube video by Bruce Springsteen Land of Hope and Dreams

Tonight, Bruce Springsteen and The E Street Band opened their Land of Hope & Dreams Tour. Bruce launched this run of shows with three statements about the situation in the United States, with comments preceding his songs Land of Hope and Dreams, House of a Thousand Guitars and My City of Ruins.

This made me smile, thank you!😀 The last few weeks have definitely felt like The Bear. Also submitting a proposal too! It's been oddly rejuvenating for my soul to be moving projects over the finish line with all the awfulness RE science funding going on....

Conference organizers with Mark Stoneking

Thank you @martamlahr.bsky.social @lquintanamurci.bsky.social @aliceleplongeon.bsky.social @cschlebu.bsky.social for organizing a such a fantastic mtg!!! Lots of great science and fun!😃👏 #HumanEvo25

Keynote talk from OG Mark Stoneking on the peopling of the Pacific! #HumanEvo25

Kirk Lohmueller

DominL uses patterns of archaic ancestry to infer degree of dominance. Provides statistical support for the presence of recessive deleterious mutations in the human genome. Up to 15% of the human genome may carry recessive deleterious mutations! 🧬

#HumanEvo25

ML, allele dominance, selection and fitness informing on #Neanderthal introgression by @klohmueller.bsky.social 🥰 🧬!
#HumanEvo25

@paleogenomics.bsky.social speaking about the effects of colonization on Mexican genetic variation #HumanEvo25

@amygoldberg.bsky.social telling us about integrating genetic variation and archeology to infer recent processes #HumanEvo25

Yummy tri-tip

Easter tri-tip! This is going to taste even better after my 7.5 mile run this AM. Trying to find some joy despite everything. Nervous about what this week will bring…

Accessible, realistic genome simulation with selection using stdpopsim Selection is a fundamental evolutionary force that shapes patterns of genetic variation across species. However, simulations incorporating realistic selection along heterogeneous genomes in complex de...

stdpopsim v0.3.0 is out! You can now mix and match your simulations of different demographic histories with published distributions of fitness effects along with gene annotations, and you can even throw in sweeps for good measure. Check out the new manuscript for more info: doi.org/10.1101/2025...

My review of computational methods for anthropological genetics with @kwittadna.bsky.social is out for the Yearbook issue of AJBA.

We talk about all sorts of cool methods that YOU could use too!

Also check out this great figure we commissioned from @janey1216.bsky.social

doi.org/10.1002/ajpa...

Come join us at UCLA!

Great question! I can't think of any off the top of my head that were shown to be due to epistasis. But, this could be that we don't know the mechanisms in most cases.

The Genetics Society of America @genetics-gsa.bsky.social is "advocating for science and for scientists. We seek to cultivate an inclusive, diverse research community that engages with the public...& serves as an authoritative source of information." Pls consider joining genetics-gsa.org/membership/

Registration is now open for the Gordon Research Seminar (GRS) on Ecological and Evolutionary Genomics in Tuscany, co-chaired by me and @jcbnunez.bsky.social! This meeting is a unique opportunity for early-career researchers to present their work and network.

www.grc.org/ecological-a...

Director, Institute for Quantitative and Computational Biosciences University of California, Los Angeles is hiring. Apply now!

UCLA QCBIO is looking for its next director! Please consider applying! recruit.apo.ucla.edu/JPF10007

Mountains at the start of the Henninger Flats hike north of LA

Kirk at the top of Henninger Flats overlooking downtown LA in the background in the haze.

Kirk with more mountains

Last bit of calm to the start of the new year before what promises to be a chaotic (hopefully in a good way!) quarter🫠This is one of many beautiful hiking paths near LA.

GSA’s on Bluesky, y’all! Do follow us for updates on everything we do as a scientific society, including amazing science in Genetics and G3!

No worries😀 Looking forward to working with you!