Rajan Kumar Pandey

#scicommUU25 The success of my research could shift the autoimmune treatment paradigm from chronic suppression to targeted tolerance. That means fewer side effects, better long-term outcomes, and maybe true remission. I hope for the best.

01.06.2025 12:25 — 👍 1    🔁 1    💬 0    📌 0

Human MHC Class II and Invariant Chain Knock‐in Mice Mimic Rheumatoid Arthritis with Allele Restriction in Immune Response and Arthritis Association Physiologically accurate mouse strains, surpassing the limitations of transgenic approaches, are made with knock-in technology replacing extracellular domains of HLA-DRA, HLA-DRB1*04:01/*04:02, and C...

#scicommUU25 Our team has recently developed humanized mouse models that physiologically express human MHC class II alleles along with human CD4 and LAG-3. These models offer a powerful platform to study human immune responses in vivo. Read here: advanced.onlinelibrary.wiley.com/doi/full/10....

01.06.2025 12:23 — 👍 0    🔁 0    💬 0    📌 0

Tolerogenic antigen-specific vaccine induces VISTA-enriched regulatory T cells and protects against arthritis in DRB1∗04:01 mice Romero-Castillo and colleagues developed a novel tolerogenic vaccine against rheumatoid arthritis using a modified collagen peptide bound to HLA-DRB1∗04:01. This vaccine induces VISTA-positive regulat...

#scicommUU25 Curious about tolerogenic vaccines and RA? Read our recently published work in Molecular therapy Journal.

1. Tolerogenic antigen-specific vaccine induces VISTA-enriched regulatory T cells and protects against arthritis in DRB1∗04:01 mice (www.cell.com/molecular-th...

01.06.2025 12:19 — 👍 0    🔁 0    💬 0    📌 0

#scicommUU25 Being a rheumatologist, developing a tolerogenic vaccine that teaches the immune system to tolerate the body’s own tissues again, instead of attacking them. Imagine resetting immune memory without suppressing it entirely. It’s going well, and the implications could be huge!

01.06.2025 12:15 — 👍 0    🔁 0    💬 0    📌 0

#scicommUU25 Current RA treatment often suppress the immune system to reduce symptoms, but this can leave patients more susceptible to infections. What we need are smarter, safer solutions. That’s where tolerogenic vaccines come in: a promising, more targeted alternative.

01.06.2025 12:14 — 👍 0    🔁 0    💬 0    📌 0

#scicommUU25 Rheumatoid Arthritis is an autoimmune disease where the immune system mistakenly attacks the joints, leading to pain, swelling, and long-term damage. It affects millions globally and where women get affected 2-3 times more in comparison to men. Till now, no vaccine for this disease.

01.06.2025 12:10 — 👍 0    🔁 0    💬 0    📌 0

DOI: 10.1016/j.ymthe.2025.04.034

#scicommUU25 As a rheumatologist, my research work focuses on tolerogenic vaccines for rheumatoid arthritis (RA). The goal is to reduce the immune system's overactive response to self-antigens, promoting immune tolerance and providing protection against this chronic inflammatory condition.

01.06.2025 12:01 — 👍 0    🔁 0    💬 0    📌 0