Cellular and Molecular Gastroenterology and Hepatology (CMGH)

Loss of intestinal sorting nexin 27 disrupts epithelial barrier function and promotes inflammation, identifying SNX27 as a key regulator of gut homeostasis and a potential target in inflammatory disease.
🔗https://ow.ly/AUXi50YrxlC
🏷️ #GutBarrier

🔬 This study presents a new model of gastric pre-neoplasia driven by aberrant ADAR1-mediated double-stranded RNA signaling, revealing how dysregulated RNA editing and innate immune activation promote early gastric tumor development.
🔗 https://ow.ly/h2M950YrvS7
🏷️ #GastricCancer

🔬 Probiotics counter high-cholesterol diet–driven fatty liver and pancreatic cancer by restoring macrophage homeostasis
📑 The study shows, highlighting immune–microbiome interactions as a promising therapeutic target.
🔗 https://ow.ly/97ms50YrsVP
🏷️ #GutMicrobiome #Immunology

📣 Calling all early-career GIs and PhDs! The AGA Journals are now accepting applications for a one-year editorial fellowship program focused on editorial training and leadership development.
⏰ Apply by April 30, 2026
🔗 Details and application: ow.ly/CSP050YrtKc

📑 Check out this research article published in the latest issue of CMGH ➡️ "GPR68, A Proton-sensing GPCR, Mediates Acid-induced Visceral Nociception"
🔗 https://ow.ly/yRNM50YoTJ1

📚 This study reveals that Cilk1 is essential for mesenchymal ciliogenesis and Hedgehog signaling, coordinating epithelial–mesenchymal communication required for intestinal villus morphogenesis.
🔗 https://ow.ly/L23050YoTEU

📚 The study by Schonfeld et al found that acute phase response after alcohol cessation triggers intrahepatic cell-cell communication changes that promote fibrosis regression.
🔗 https://ow.ly/c9KH50YkprB
🏷️ #LiverHealth

🌟 Check out this #featuredarticle ➡️ "Androgen Signaling in ILC2s Drives Sex Differences in Helicobacter-induced Gastric Inflammation and Atrophy"
🔗 https://ow.ly/BbFz50Ykp25
🏷️ #SexDifferences #GutHealth

🍼 Breast milk glutamine/glutamate show dual effects in neonatal enteritis: protective before onset but harmful during disease via macrophage metabolic reprogramming.
🔗 https://ow.ly/7c3M50YkoRB
🏷️ #FeaturedArticle #GutHealth

😣 Stress often triggers abdominal pain in #IBS 😬Duan S et al. reveal that sympathetic nerve overactivation stimulates gut fibroblasts to attract eosinophils, leading to abdominal pain in IBS
🔗 https://ow.ly/RJ0850YhiKp

👀 Check out this #featuredarticle 📚 A commentary on mechanistic insights in #pancreaticcancer
🔗 https://ow.ly/mKea50YhlFq
➡️ View the full #Pancreas article collection on CMGH's website here: https://ow.ly/VeXZ50YhlC7

🔎 New research reveals inflammatory secretory progenitor cells in #crohnsdisease with open chromatin at inflammatory gene loci—showing how gut epigenetics are rewired in #IBD #IntestinalStemCells #EditorsEssentialReading
🔗 https://ow.ly/Rgqa50YhigW

⭐ The latest issue of CMGH's 20th volume is available now! 🔗 https://ow.ly/AXMA50YhgCs

🐁 Using a “Telomouse” model with human‑length telomeres, researchers show that short telomeres impair liver regeneration, limiting hepatocyte and cholangiocyte proliferation and increasing DNA damage after partial hepatectomy.
🔗 https://ow.ly/yLEb50YbNgR
🏷️ #LiverHealth

➡️ ATG16L1 in peritoneal macrophage drives liver repair in DILI by enhancing phagocytosis and a reparative phenotype via autophagy-MerTK and promoting hepatocyte proliferation via the IL-10-CXCR2 axis.
🔗 https://ow.ly/CoH550YbMSH
🏷️ #GutHealth

🔬 Scientists reveal RACK1 fine-tunes liver signals by organizing glucagon pathways in two compartments, enabling proper glucose production to control blood sugar while leaving insulin action unaffected.
🔗 https://ow.ly/SGxu50YbMGx
🏷️ #GutHealth

Loss of OTUD3 disrupts gut barrier and drives inflammation in UC. Linked with a rare mutation to common disease, uncovering an epithelial-intrinsic mechanism for colitis.
🔗 https://ow.ly/7n0L50Y7Wuc
🏷️ #IBD #GutHealth

⛓️‍💥 Loss of Brg1 and Pten in pancreatic ductal cells results in formation of pancreatic intraductal tubulopapillary neoplasm in a mouse model via activation of YAP/TAZ pathway.
🔗 https://ow.ly/FsLv50Y46eu
🏷️ #EditorsEssentialReading

⭐ In the final video celebrating the journal's 10th anniversary, Jonathan P. Katz, MD, co-Editor-in-Chief, talks about the origin and continued growth of #CMGH, as well as his own journey from AE to EIC. ⭐

➡️ Watch it here: https://ow.ly/435l50Y4XSG
#CelebrateCMGH

📣 Check out this research article as it explores how hyperactive enteric glia make gut neurons change bowel habits following inflammation!
🔗 https://ow.ly/RJel50Y4612
🏷️ #GutHealth

⭐ The newest issue of CMGH is now available! Check it out!
🔗 https://ow.ly/ecFR50Y45PI

🔍 ATG16L1 in peritoneal macrophage drives liver repair in DILI by enhancing phagocytosis and a reparative phenotype via autophagy-MerTK and promoting hepatocyte proliferation via the IL-10-CXCR2 axis.
🔗 https://ow.ly/9Eff50Y0pYK

➡️ Loss of OTUD3 disrupts gut barrier and drives inflammation in UC. The authors linked a rare mutation to common disease, uncovering an epithelial-intrinsic mechanism for colitis.
🔗 https://ow.ly/zsZh50Y0pTv
🏷️ #IBD #GutHealth #Colitis

⭐ The EP300/YAP1-SERPINE1 pathway promotes liver fibrosis (LF) in biliary atresia (BA) by regulating ductular reaction. Inhibiting EP300 reduces LF in BA models, providing a novel therapy strategy.
🔗 https://ow.ly/eNK650Y0pIM
🏷️ #GIHealth #LiverFibrosis

Check out this full length research article and editorial on suckling rabbits 🐇
Research Article 🔗 https://ow.ly/zXIe50XVTAi
Editorial 🔗 https://ow.ly/15PO50XVTAh
🏷️ #GIHealth #GutHealth #Organoids

⏲️ Loss of Bsep reduces toxin-induced liver fibrosis in mice by suppressing pJNK signaling and hepatic stellate cell activation. THBAs attenuate fibrosis markers, offering potential therapeutic insights.
🔗 https://ow.ly/xmKm50XVTya
🏷️ #LiverResearch #Fibrosis

➡️ Using K19-Wnt1/C2mE mice with a high-fat diet with LPS administration, we revealed an interorgan network linking metabolic endotoxemia and gastric cardia adenocarcinoma via the NRF2-PD-L1 signaling.
🔗 https://ow.ly/JvvB50XVTwx
🏷️ #GIHealth

📑 Using K19-Wnt1/C2mE mice with a high-fat diet with LPS administration, we revealed an interorgan network linking metabolic endotoxemia and gastric cardia adenocarcinoma via the NRF2-PD-L1 signaling.
🔗 https://ow.ly/w9Qr50XSg0o

➡️ Human placental extract prevents damage and increases repair in in vivo and in Avitro models of NEC-injury, respectively, via increased epithelial wound healing, migration, and proliferation.
🔗 https://ow.ly/fiUL50XSfYW

📑 Intestinal CADM1 expression is elevated in IBD and pharmacological inhibition of Cadm1 in mice attenuated chemical-induced colitis suggesting this membrane protein may constitute an IBD therapeutic.
🔗 https://ow.ly/KH3v50XSfVl