Raffaele Colombo

Don't miss "The Journey of Antibody–Drug Conjugates: Lessons Learned from 40 Years of Development," a Cancer Discovery review by #AACR25 speakers Elisabeth de Vries and @raffcolo.bsky.social (along with Pat LoRusso & @ptarantinomd.bsky.social) doi.org/10.1158/2159...

For a summary of how ADC payload class has evolved over time (up to August 2024), see: aacrjournals.org/cancerdiscov...

Sharing for the 🦋 aficionados:

A record of 77 new ADCs entered clinical development in 2024 (including those accepted but not yet started).

Payload class clearly dominated by topo1i with 55 ADCs.

Greater diversity observed for antibody targets, featuring novel TAAs and several bispecific ADCs.

ADC (in)stabilities:
- Both sacituzumab govitecan (SG) and sacituzumab tirumotecan (sac-TMT) have an unstable carbonate linker (half-life ~24 h) that releases their respective payloads over time
- SG has an additional point of instability (thiol-maleimide conjugation)

Get ready for #SABCS24

Small preview from Wednesday’s #SABCS24 session on the future of ADCs

Question: what do all these ongoing phase 3 ADC trials have in common?

🗓️ Dec 11, 3.30 pm, Hemisfair Ballroom 1-2

ADC trivia: what’s the linker stability of the newly approved (by Chinese NMPA) sacituzumab tirumotecan?

1, 2, 3, 4, 5, 6, 7, or 8?

For more info on ADC linker (in)stabilities: aacrjournals.org/cancerdiscov...

www.prnewswire.com/news-release...

Sacituzumab tirumotecan (aka sac-TMT aka SKB264/MK-2870) approved in China for patients with advanced or metastatic triple negative breast cancer (TNBC) who have received at least 2 prior therapies.

This brings the total number of approved ADCs to 13 worldwide (of which 11 by US FDA)!

The biparatopic anti-HER2 mAb zanidatamab is now approved for treating HER2+ biliary tract cancer. Zanidatamab simultaneously binds to the trastuzumab- and pertuzumab binding domain of HER2. Phase 3 trial ongoing in pretreated HER2+ MBC, led by Sara Tolaney. www.fda.gov/drugs/resour...

Ziihera approved!! 🎉🎉

www.prnewswire.com/news-release...

Congrats!!

Upcoming early-phase ADC data at #ASH24
(including two interesting preclinical ADCs)

66th ASH Annual Meeting (December 7-10, 2024), full program: ash.confex.com/ash/2024/web...

Note: late-breaking abstracts available online on November 25!

#ADC #ADCs

Only 3 weeks to #SABCS24, a meeting that promises to significantly impact the way we treat breast cancer. It will feature phase 3 data with novel SERDs, novel ADCs, immunotherapy, ctDNA monitoring, important biomarker analyses & so much more. Here’s my top 10 abstracts list— see you in San Antonio!

The Journey of Antibody–Drug Conjugates: Lessons Learned from 40 Years of Development Abstract. Antibody–drug conjugates (ADC) represent one of the most rapidly expanding treatment modalities in oncology, with 11 ADCs approved by the FDA and more than 210 currently being tested in clin...

aacrjournals.org/cancerdiscov...

#drugdevelopment #adcs #antibodythereapeutics #science #cancer