Ian T. Ellwood

Mind-blowing to see a project I was part of be on Colbert.

07.02.2025 17:55 — 👍 2    🔁 0    💬 0    📌 0

Wrote my congressman and senators today to ask them to speak up against the sudden and capricious cancellation of study sections at the NIH. Delaying funding for essential research into human health is idiotic.

23.01.2025 17:07 — 👍 2    🔁 1    💬 0    📌 0

Devastating is right. All NIH study sections and council meetings through Feb 1 canceled. 100s of grant’s review and consideration needlessly halted. Each application represents years of work carefully structured into a proposal to tackle the next most important questions in biomedical research.

23.01.2025 02:00 — 👍 3    🔁 2    💬 1    📌 0

Schematic of the experiment

Our latest work led by @claraliao.bsky.social is a collaboration with the other Kwan lab @kwanlab.bsky.social

We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. 🍄 🧠 🧬

www.biorxiv.org/content/10.1...

06.01.2025 12:49 — 👍 99    🔁 31    💬 4    📌 1

MouseGoggles: an immersive virtual reality headset for mouse neuroscience and behavior - Nature Methods MouseGoggles is a miniaturized virtual reality (VR) headset for mice that provides an improved immersive experience compared with existing VR equipment. MouseGoggles can also be combined with pupil tr...

MouseGoggles paper is now up on Nature Methods! A mouse VR headset with eye tracking! Lead authors Matt and Hongyu put in incredible effort in this project and it shows!
www.nature.com/articles/s41...

19.12.2024 19:39 — 👍 2    🔁 0    💬 0    📌 0

Based on these findings, we propose that dopamine release depends on the "total valence" of a stimulus, or S = reward + aversion.

17.12.2024 14:40 — 👍 1    🔁 0    💬 0    📌 0

We also found that omissions of expected stimuli do not trigger release and that several stimuli with little or no valence lead to minimal release even when they are engaging, showing that PFC dopamine is not simply a surprise signal.

17.12.2024 14:40 — 👍 1    🔁 0    💬 1    📌 0

Dopamine release in the prefrontal cortex (PFC) is fascinating because it occurs following both reward and aversion. Here we tested what happens when you mix reward and aversion and found that amount of release seemed to depend on the sum of the rewarding and aversive components.

17.12.2024 14:40 — 👍 0    🔁 0    💬 1    📌 0

Proud to present work from my graduate student Yating Yang that just posted on BioRxiv.
www.biorxiv.org/content/10.1...

17.12.2024 14:40 — 👍 4    🔁 1    💬 1    📌 0