Stacy Horner

So, so, honored by this award—it is daunting to know that my heroes have won this award! Thanks to my heroes and mentors, and my trainees, who are everything!!!!

The mechanistic basis and cellular functions of UFMylation Nature Reviews Molecular Cell Biology, Published online: 09 January 2026; doi:10.1038/s41580-025-00944-yUFMylation, a ubiquitin-like modification, regulates endoplasmic reticulum-associated ribosome quality control by conjugating UFM1 to the ribosomal subunit RPL26, preserving ribosome integrity under stress. This Review explores the structural basis of UFMylation and its emerging functional breadth, and it discusses putative UFMylation substrates.

New Online! The mechanistic basis and cellular functions of UFMylation

URichmond is hiring two tenure-track faculty. One in biochemistry/chemical biology and the other in experimental physical chemistry. This is a terrific place to work - our focus is on our talented undergraduates and we have robust research resources. chemistryjobs.acs.org/job/assistan...

Diagram showing how UFL1 interacts with flaviviral NS2A, Capsid, and NS3 proteins to promote viral assembly.

Excited to share our new paper led by recent PhD, Dr. Hannah Schmidt! We found that UFMylation unexpectedly promotes flavivirus particle production by specifically regulating viral assembly. Check it out! #virology #UFMylation #flaviviruses
journals.asm.org/doi/10.1128/...

The Wadsworth Center is expanding it's research focus on #virology /vector-borne diseases!
www.asmcareerconnections.org/job/research-scientist-5-g-31/78488664/
This is a unicorn assistant prof equivalent position with 12-month hard money salary and no teaching commitments (!)
Reposts appreciated 🙏

A study reveals the effects of Florida's new public university post-tenure review:

* higher rate of faculty departure
* younger star faculty were more likely to leave
* new hires were less likely to be stars
* low-performing faculty didn't increase their performance

papers.ssrn.com/sol3/papers....

Research Assistant - RNA Therapeutics Core Facility

We are looking for a talented Research Assistant to work in the #RNATherapeutics Core Facility at the @ircm.bsky.social in beautiful Montreal.

More details on the position and on how to apply here:
www.ircm.qc.ca/en/position-...

IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity The mammalian endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is essential for cellular homeostasis and plays key roles …

www.sciencedirect.com/science/arti... @drbadbug.bsky.social @teresaomeara.bsky.social Overall, our findings illustrate non-canonical IRE1α activation during infection and a function for IRE1α in supporting organelle contact sites to safeguard against rapidly growing microbes.

Congrats Mike et al!!

Super psyched to have leading investigator @thehornerlab.bsky.social presenting her team's work THURSDAY 15th May on Zoom.
#flavivirus #virus-host-interactions #innate_immunity #DENV #ZIKV
All are very welcome and please re-post to get the word out. Email organisers for Zoom link. See you there!

Terrence S. Dermody and Julie K. Pfeiffer: To tackle chronic disease, turn to the virologists Despite the United States being a global leader in many areas, Americans are not healthy. Life expectancy is lower than in other industrialized nations,...

Terry Dermody and I wrote an op-ed about chronic diseases ("Make America Healthy Again"), the role of viral infections, and how virologists can help. www.post-gazette.com/opinion/gues...

How cuts at the National Institutes of Health could impact Americans' health Cuts and layoffs to the National Institutes of Health threaten medical research around the U.S., agency insiders warn.

The National Institutes of Health, the largest funder of biomedical research in the world, has fired 1,300 employees and cancelled more than $2 billion in federal research grants. https://cbsn.ws/4daiCrv

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

Itai Yanai speaking in front of thousands of participants at the Stand Up for Science event in front of the Lincoln Memorial in Washington, D.C.

Inspiring speakers highlighting the importance to our collective health as well as economic return on investment of basic, curiosity-driven research at yesterday’s @standupforscience.bsky.social

Frightening to see active dismantling of decades of public investments in our health and futures.

Universities are facing big cuts to research funding. At Duke, it's a time for 'damage control' Facing the potential loss of hundreds of millions of dollars in federal funding, Duke University is preparing for the worst.

Great story by AP’s Mayika Seminara about how Duke scientists are responding to uncertainty. apnews.com/article/trum...

Universities are facing big cuts to research funding. At Duke, it's a time for 'damage control' Facing the potential loss of hundreds of millions of dollars in federal funding, Duke University is preparing for the worst.

Not only are we limiting our medical research and advancement of new treatments, but NIH cuts are affecting ability of universities to take on grad students, limiting our future workforce @altcdc.altgov.info @altnih4science.bsky.social #science #cuts #resist

apnews.com/article/trum...

Inside the Collapse at the NIH Administration officials pressured the NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.

www.theatlantic.com/health/archi...

Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article) Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

Trump Administration Stalls Scientific Research Despite Court Ruling www.nytimes.com/2025/02/21/s...

Finally a Friday evening with GOOD news 🙌🏽

So grateful for people who are willing to stand up and fight for what’s right instead of prematurely bowing to injustice.

🚨BREAKING: Federal Court GRANTS sweeping nationwide injunction against Trump DEI executive orders finding that they violate First and Fifth Amendments to the Constitution. A huge victory for @democracyforward.org and its clients. A stinging loss for Trump.

Visit www.democracydocket.com for details.

Federal Register hold makes ‘end run’ around court pause on NIH funding freeze NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

A large portion of grants awarded by the U.S. National Institutes of Health cannot be funded for the foreseeable future because of an indefinite hold on submissions to the Federal Register, according to an email reviewed by The Transmitter.

By @avaskham.bsky.social

bit.ly/3X8ngz8

I had two grant proposals up for review in the NIH Bacterial Virulence (BV) study section. It was canceled without notice this morning.
Without those grants, my lab must close within a year.
And so the purge of scientific research in the US continues
🤬
#MicroSky 🦠🧫🧪🧬🔬

Federal Register hold makes ‘end run’ around court pause on NIH funding freeze NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...

So a former postdoc from our department had just started as a PO at NIH and was terminated in the wave of terminations last week. He is in the research triangle and a phenomenal scientist with expertise in stress and glia. If anyone in the RTI is hiring asap please let me know! #neuroskyence

Anger, despair, and defiance from a voice within the US federal research system People around the world are watching with disbelief as the new US government closes down its aid programme, withdraws from the World Health Organization (WHO) and the Paris agreement on climate change...

This is gut-wrenching 😭😱https://www.bmj.com/content/388/bmj.r294

a poster that says if life gives you lemon make lemonade on it ALT: a poster that says if life gives you lemon make lemonade on it

ATTENTION (PLEASE SHARE)

If anyone has or knows of any positions that might be appropriate for the NIH staff members who were terminated, please post the information in this thread.

There are lots of talented and accomplished people who may be looking for new opportunities.

Executive wants to frame the NIH indirects cut as $4B in savings.

But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates Notice Number: NOT-OD-25-068 Key Dates Release Date: February 7, 2025 Related Announcements None Issued by Office of The Director, National Institutes of Health (OD) Purpose

🚨RED ALERT for 🧪:

The Trump NIH just gashed indirect costs. This is a direct attack on universities.

“Pursuant to this Supplemental Guidance, there will be a standard rate of 15% across all NIH grants for indirect costs.” 😮

Just a devastating Friday night news dump. #scicomm #academicaky

Exposure of negative-sense viral RNA in the cytoplasm initiates innate immunity to West Nile virus For many RNA viruses, immunity is triggered when RIG-I-like receptors (RLRs) detect viral RNA. However, only a minority of infected cells undergo inna…

A fantastic paper from @immunuelle.bsky.social & @mgalejr.bsky.social. New insights into RNA sensing of viruses.
www.sciencedirect.com/science/arti...