Hamilton Lab @ VCU

So cool! Congrats!!

Ayyy, thanks newly minted Gowrishankar Lab. Hope starting the lab is going well!

Derepression of transposable elements in the mouse prefrontal cortex disrupts social behavior | PNAS The neurobiological origins of social behaviors are poorly understood. Previous studies have linked the function of a single Krüppel-associated box...

In a recent pub, grad students Kijoon and Corinne co-led a study where we made molecular tools to manipulate transposable elements (TEs) in mouse prefrontal cortex. We saw that transcriptional escape of brain TEs uniquely impaired complex social behavior.

Read it here:

www.pnas.org/doi/10.1073/...

Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward - Nature Communications Here Jaster et al., show a single psilocybin dose produce sex-specific post-acute changes in opioid reward and withdrawal via 5-HT2A receptors in frontal cortex-to–nucleus accumbens circuits, with epi...

My dissertation paper finally dropped in Nature Communications!

Overall, the conclusion is that psilocybin may be useful in reducing drug craving that often precipitates relapse through mechanisms related to 5-HT2A activation.

www.nature.com/articles/s41...

Congrats Raaj!

The Gowrishankar lab will be opening its doors @neuro_MUSC on Dec 1, 2025! We will be hiring at all levels. I will also be at @SfNtweets presenting my lab's vision on Wednesday, Nov 19, 8AM-12PM at poster board GG7. If you're interested, please reach out!

www.raajgowrishankarlab.org

In a new paper, we analyze published RNAseq and discover impact to the expression of transposable element transcripts in the brains of people with major depressive disorder. Natalie Truby, a recent-grad from the lab, spearheaded this work.

Read about it here:
doi.org/10.1016/j.ja...

In this preprint, grad students Kijoon Kim and Corinne Smith re-programmed the function of the KZFP-interacting protein TRIM28. We discover that TRIM28 disfunction in mouse PFC releases TEs and impedes complex social behaviors. The work is an ode to community. Read about it below!

A HUGE CONGRATULATIONS to @ericjnestler.bsky.social on being named Interim Dean of the Icahn School of Medicine! As we express great enthusiasm for Dr. Nestler becoming Dean & the exciting time ahead, please join us in thanking Dean Charney for his extraordinary service & commitment to Mount Sinai.

Open-Rank Faculty Cluster Hire in Depression Research University of California, Irvine is hiring. Apply now!

Pls share AMAZING opportunities! Studying Depression? its biology? UCI’s new Depression Res Ctr is hiring 1) Preclinical Models: systems mechanisms of vulnerability, resilience 2) Child Adolescent, Adult Depression 3) Biomed Engineer Deep Phenotype, Intervention recruit.ap.uci.edu/JPF09510 508, 507

UAB Neurobiology is hiring up to 4 new tenure-track faculty as part of 3 new open-rank searches. Come join our vibrant, supportive, and growing neuroscience community!
uab.peopleadmin.com/postings/23916
uab.peopleadmin.com/postings/23944
uab.peopleadmin.com/postings/24010