Kalli Kappel

Roadtrip. For some, it might be vacation, for others it's a roadtrip from their postdoc to their new lab. I interviewed two scientists who kindly shared personal insight into what that feels like. And yes, they know that many are not having the good fortunate of landing a faculty job just yet. A 🧵

How to spy on condensates - Nature Methods Scientists track how these membraneless biomolecular foci self-organize for their cellular tasks.

How to spy on condensates: technology feature in
@natmethods.nature.com
Our views on the topic, by Hyman,Rosen,Brangwynne, Sabari, Kappel,Xu & myself, presented here
@hymanlab.bsky.social @brangwynnelab.bsky.social @bsabari.bsky.social @kallikappel.bsky.social
www.nature.com/articles/s41...

Thanks so much Dennis!!

Thanks so much Krishna!!

I will continue building on this approach in my own lab, opening in July at UCLA — if you’re interested in this kind of work, please reach out!

I’m super grateful to all my co-authors for helping to make this project a reality, especially my postdoc advisors Aviv Regev and Feng Zhang.

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!

rdcu.be/eq975